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Case Report: Primary dural based diffuse large B-Cell lymphoma in a 14 year-old boy.

Munakomi S, Bhattarai B, Srinivas B, Cherian I - F1000Res (2015)

Bottom Line: Post-operatively, the patient showed good recovery.He was then referred to the oncology unit for further chemo- and radiation therapy.A high index of suspicion should therefore be kept in order to diagnose the condition in a timely fashion and then plan for appropriate management since diffuse large cell lymphoma has a relatively benign clinical prognosis.

View Article: PubMed Central - PubMed

Affiliation: International Society for Medical Education, College of Medical Sciences, Bharatpur, Chitwan, 44207, Nepal.

ABSTRACT
Primary dural lymphoma is a subentity of primary leptomeningeal lymphoma which represents 0.1% of all non-Hodgkin's lymphomas. Only five cases have been reported so far. We report a very rare case of primary dural-based lymphoma in a 14 year-old boy presenting with mass effect. The patient was managed with excision of the lesion and removal of the involved bone. Post-operatively, the patient showed good recovery. He was then referred to the oncology unit for further chemo- and radiation therapy. A high index of suspicion should therefore be kept in order to diagnose the condition in a timely fashion and then plan for appropriate management since diffuse large cell lymphoma has a relatively benign clinical prognosis.

No MeSH data available.


Related in: MedlinePlus

Photograph of the involved dura.
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f5: Photograph of the involved dura.

Mentions: Because the child was already herniating, he was started on intravenous dexamethasone (4mg over 8 hours) and a single 100ml dose of 25% mannitol was given. Parents were counseled and written consent was taken for operative management. Surgery revealed a dural-based lesion (Figure 5) that was moderately vascular, soft and friable in consistency with involved bone showing a moth-eaten appearance (Figure 6). Both extra- and intra-dural extension (Figure 7 andFigure 8) of the lesion was seen. Scalp lesions, involved bone, and the dural and intradural component were all excised and sent for histopathological (HPE) study. A post-operative scan showed gross excision of the lesions and absence of mass effect (Figure 9). The HPE revealed an immunoblastic variant of diffuse large cell lymphoma (Figure 10).


Case Report: Primary dural based diffuse large B-Cell lymphoma in a 14 year-old boy.

Munakomi S, Bhattarai B, Srinivas B, Cherian I - F1000Res (2015)

Photograph of the involved dura.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4482212&req=5

f5: Photograph of the involved dura.
Mentions: Because the child was already herniating, he was started on intravenous dexamethasone (4mg over 8 hours) and a single 100ml dose of 25% mannitol was given. Parents were counseled and written consent was taken for operative management. Surgery revealed a dural-based lesion (Figure 5) that was moderately vascular, soft and friable in consistency with involved bone showing a moth-eaten appearance (Figure 6). Both extra- and intra-dural extension (Figure 7 andFigure 8) of the lesion was seen. Scalp lesions, involved bone, and the dural and intradural component were all excised and sent for histopathological (HPE) study. A post-operative scan showed gross excision of the lesions and absence of mass effect (Figure 9). The HPE revealed an immunoblastic variant of diffuse large cell lymphoma (Figure 10).

Bottom Line: Post-operatively, the patient showed good recovery.He was then referred to the oncology unit for further chemo- and radiation therapy.A high index of suspicion should therefore be kept in order to diagnose the condition in a timely fashion and then plan for appropriate management since diffuse large cell lymphoma has a relatively benign clinical prognosis.

View Article: PubMed Central - PubMed

Affiliation: International Society for Medical Education, College of Medical Sciences, Bharatpur, Chitwan, 44207, Nepal.

ABSTRACT
Primary dural lymphoma is a subentity of primary leptomeningeal lymphoma which represents 0.1% of all non-Hodgkin's lymphomas. Only five cases have been reported so far. We report a very rare case of primary dural-based lymphoma in a 14 year-old boy presenting with mass effect. The patient was managed with excision of the lesion and removal of the involved bone. Post-operatively, the patient showed good recovery. He was then referred to the oncology unit for further chemo- and radiation therapy. A high index of suspicion should therefore be kept in order to diagnose the condition in a timely fashion and then plan for appropriate management since diffuse large cell lymphoma has a relatively benign clinical prognosis.

No MeSH data available.


Related in: MedlinePlus