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Cardiovascular magnetic resonance compatible physical model of the left ventricle for multi-modality characterization of wall motion and hemodynamics.

Okafor IU, Santhanakrishnan A, Chaffins BD, Mirabella L, Oshinski JN, Yoganathan AP - J Cardiovasc Magn Reson (2015)

Bottom Line: DPIV and PC-CMR results of the center plane flow within the ventricle matched, both qualitatively and quantitatively, with flow from the atrium into the LV having a velocity of about 1.15 m/s for both modalities.The mean difference between CMR and SP was 5.5 ± 3.7%.The model presented here can thus be used for the purposes of: (a) acquiring CMR data for validation of FSI simulations, (b) determining accuracy of cine-CMR reconstruction methods, and

View Article: PubMed Central - PubMed

Affiliation: School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, USA. iokafor3@gatech.edu.

No MeSH data available.


Anatomical physical model of the flexible-walled LV: design of the model using a series of concentric ellipses connected via splines is shown in (a), and (b) shows the 3D schematic of the geometry.
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Fig1: Anatomical physical model of the flexible-walled LV: design of the model using a series of concentric ellipses connected via splines is shown in (a), and (b) shows the 3D schematic of the geometry.

Mentions: The left ventricular geometry was generated in SolidworksTM (Dassault Systèmes Solidworks Corporation, Waltham, MA, USA) by constructing a series of concentric ellipses that were fit to LV endocardial borders traced on 5 cine steady-state free procession (SSFP), short axis slices at peak systolic phase of the cardiac cycle acquired in a healthy subject’s (Fig. 1). A 125° cut was made at the base of the ventricle such that the mitral and aortic annular planes matched in vivo conditions [32]. The design was sent to a third party company (VenAir, Terrassa, Spain) for tool building and casting. Silicone, with a shore hardness of 42A and a thickness of 0.159 cm, was used as the material for the ventricle casting. This hardness was chosen to provide the flexibility and durability needed for pumping function, while simultaneously to allow optical access for flow visualization inside the ventricle. The patient data collected for the construction of the LV was approved by the institutional review board (IRB# H09236).Fig. 1


Cardiovascular magnetic resonance compatible physical model of the left ventricle for multi-modality characterization of wall motion and hemodynamics.

Okafor IU, Santhanakrishnan A, Chaffins BD, Mirabella L, Oshinski JN, Yoganathan AP - J Cardiovasc Magn Reson (2015)

Anatomical physical model of the flexible-walled LV: design of the model using a series of concentric ellipses connected via splines is shown in (a), and (b) shows the 3D schematic of the geometry.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4482204&req=5

Fig1: Anatomical physical model of the flexible-walled LV: design of the model using a series of concentric ellipses connected via splines is shown in (a), and (b) shows the 3D schematic of the geometry.
Mentions: The left ventricular geometry was generated in SolidworksTM (Dassault Systèmes Solidworks Corporation, Waltham, MA, USA) by constructing a series of concentric ellipses that were fit to LV endocardial borders traced on 5 cine steady-state free procession (SSFP), short axis slices at peak systolic phase of the cardiac cycle acquired in a healthy subject’s (Fig. 1). A 125° cut was made at the base of the ventricle such that the mitral and aortic annular planes matched in vivo conditions [32]. The design was sent to a third party company (VenAir, Terrassa, Spain) for tool building and casting. Silicone, with a shore hardness of 42A and a thickness of 0.159 cm, was used as the material for the ventricle casting. This hardness was chosen to provide the flexibility and durability needed for pumping function, while simultaneously to allow optical access for flow visualization inside the ventricle. The patient data collected for the construction of the LV was approved by the institutional review board (IRB# H09236).Fig. 1

Bottom Line: DPIV and PC-CMR results of the center plane flow within the ventricle matched, both qualitatively and quantitatively, with flow from the atrium into the LV having a velocity of about 1.15 m/s for both modalities.The mean difference between CMR and SP was 5.5 ± 3.7%.The model presented here can thus be used for the purposes of: (a) acquiring CMR data for validation of FSI simulations, (b) determining accuracy of cine-CMR reconstruction methods, and

View Article: PubMed Central - PubMed

Affiliation: School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, USA. iokafor3@gatech.edu.

No MeSH data available.