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Squamoid Eccrine Ductal Carcinoma.

Segars K, Gopman JM, Elston JB, Carter W, Harrington MA - Eplasty (2015)

View Article: PubMed Central - PubMed

Affiliation: Nova Southeastern University College of Osteopathic Medicine, Davie, Fl.

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SEDC is a rare cutaneous malignancy that originates from eccrine glands and exhibits both squamous and adnexal ductal characteristics... SEDC can arise de novo either from normal adnexal tissue or from malignant transformation of a preexisting benign eccrine tumor... Like other ECs, SEDC has a strong predilection for local recurrence as well as a high metastatic potential reportedly up to 50%... It can present as a slow or rapidly growing nodule or plaque, exophytic and locally destructive, or entirely benign-appearing... Extensive sunlight exposure and immunosuppression are risk factors reported to increase the risk of all ECs... The differential diagnosis for SEDC includes SCC, other ECs (porocarcinoma, microcystic adnexal carcinoma), metastatic disease, Merkel cell carcinoma, and benign neoplasms... Because of the poorly understood malignant potential, difficulty of diagnosis, and the rarity of these tumors, there are no widely accepted treatment guidelines... Surgical excision appears to be the primary curative modality, with little data on the benefit of adjuvant therapy... Reports of local recurrence rates after surgical excision are reportedly up to 70%... The evidence for the role of sentinel lymph node biopsy with SEDC is lacking; however, the senior author has performed this procedure at the recommendation of an interdisciplinary tumor board conference... It stands to reason that a locally aggressive disease with high metastatic capabilities could potentially benefit from more aggressive surgical margins (1 cm) to disrupt local lymphatic channels and possibly decrease the risk for local recurrence... SEDC is a rare variant cutaneous adnexal tumor derived from the family of ECs with high metastatic potential and a sometimes misleadingly unimpressive presentation... Diagnosis can be difficult and requires an experienced dermatopathologist.

No MeSH data available.


Related in: MedlinePlus

Right lower back lesion diagnosed as squamous cell carcinoma on previous shave biopsy with final excisional biopsy results of squamoid ductal eccrine carcinoma.
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Figure 1: Right lower back lesion diagnosed as squamous cell carcinoma on previous shave biopsy with final excisional biopsy results of squamoid ductal eccrine carcinoma.


Squamoid Eccrine Ductal Carcinoma.

Segars K, Gopman JM, Elston JB, Carter W, Harrington MA - Eplasty (2015)

Right lower back lesion diagnosed as squamous cell carcinoma on previous shave biopsy with final excisional biopsy results of squamoid ductal eccrine carcinoma.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4482200&req=5

Figure 1: Right lower back lesion diagnosed as squamous cell carcinoma on previous shave biopsy with final excisional biopsy results of squamoid ductal eccrine carcinoma.

View Article: PubMed Central - PubMed

Affiliation: Nova Southeastern University College of Osteopathic Medicine, Davie, Fl.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

SEDC is a rare cutaneous malignancy that originates from eccrine glands and exhibits both squamous and adnexal ductal characteristics... SEDC can arise de novo either from normal adnexal tissue or from malignant transformation of a preexisting benign eccrine tumor... Like other ECs, SEDC has a strong predilection for local recurrence as well as a high metastatic potential reportedly up to 50%... It can present as a slow or rapidly growing nodule or plaque, exophytic and locally destructive, or entirely benign-appearing... Extensive sunlight exposure and immunosuppression are risk factors reported to increase the risk of all ECs... The differential diagnosis for SEDC includes SCC, other ECs (porocarcinoma, microcystic adnexal carcinoma), metastatic disease, Merkel cell carcinoma, and benign neoplasms... Because of the poorly understood malignant potential, difficulty of diagnosis, and the rarity of these tumors, there are no widely accepted treatment guidelines... Surgical excision appears to be the primary curative modality, with little data on the benefit of adjuvant therapy... Reports of local recurrence rates after surgical excision are reportedly up to 70%... The evidence for the role of sentinel lymph node biopsy with SEDC is lacking; however, the senior author has performed this procedure at the recommendation of an interdisciplinary tumor board conference... It stands to reason that a locally aggressive disease with high metastatic capabilities could potentially benefit from more aggressive surgical margins (1 cm) to disrupt local lymphatic channels and possibly decrease the risk for local recurrence... SEDC is a rare variant cutaneous adnexal tumor derived from the family of ECs with high metastatic potential and a sometimes misleadingly unimpressive presentation... Diagnosis can be difficult and requires an experienced dermatopathologist.

No MeSH data available.


Related in: MedlinePlus