Limits...
Menacalc, a quantitative method of metastasis assessment, as a prognostic marker for axillary node-negative breast cancer.

Forse CL, Agarwal S, Pinnaduwage D, Gertler F, Condeelis JS, Lin J, Xue X, Johung K, Mulligan AM, Rohan TE, Bull SB, Andrulis IL - BMC Cancer (2015)

Bottom Line: High Menacalc was associated with increased risk of death from any cause (P=0.0199, HR (CI)=2.18 (1.19, 4.00)).A similarly elevated risk of death was found in the subset of the Menacalc cohort which did not receive hormone or chemotherapy (n=142) (P=0.0052, HR (CI)=3.80 (1.58, 9.97)).There was a trend toward increased risk of death with relatively high Menacalc in the HER2, basal and luminal molecular subtypes.

View Article: PubMed Central - PubMed

Affiliation: Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada. catherine.forse@mail.utoronto.ca.

ABSTRACT

Background: Menacalc is an immunofluorescence-based, quantitative method in which expression of the non-invasive Mena protein isoform (Mena11a) is subtracted from total Mena protein expression. Previous work has found a significant positive association between Menacalc and risk of death from breast cancer. Our goal was to determine if Menacalc could be used as an independent prognostic marker for axillary node-negative (ANN) breast cancer.

Methods: Analysis of the association of Menacalc with overall survival (death from any cause) was performed for 403 ANN tumors using Kaplan Meier survival curves and the univariate Cox proportional hazards (PH) model with the log-rank or the likelihood ratio test. Cox PH models were used to estimate hazard ratios (HRs) for the association of Menacalc with risk of death after adjustment for HER2 status and clinicopathological tumor features.

Results: High Menacalc was associated with increased risk of death from any cause (P=0.0199, HR (CI)=2.18 (1.19, 4.00)). A similarly elevated risk of death was found in the subset of the Menacalc cohort which did not receive hormone or chemotherapy (n=142) (P=0.0052, HR (CI)=3.80 (1.58, 9.97)). There was a trend toward increased risk of death with relatively high Menacalc in the HER2, basal and luminal molecular subtypes.

Conclusions: Menacalc may serve as an independent prognostic biomarker for the ANN breast cancer patient population.

No MeSH data available.


Related in: MedlinePlus

Kaplan-Meier analysis of Menacalc for ANN tumors subclassified by immunohistochemical subtype: HER2 amplified (n = 20, top left), basal (n = 48, top right) and luminal (n = 165, bottom left). In brackets is the total number of patients followed by the number of patient deaths for each group
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
getmorefigures.php?uid=PMC4482190&req=5

Fig2: Kaplan-Meier analysis of Menacalc for ANN tumors subclassified by immunohistochemical subtype: HER2 amplified (n = 20, top left), basal (n = 48, top right) and luminal (n = 165, bottom left). In brackets is the total number of patients followed by the number of patient deaths for each group

Mentions: When the tumors were subdivided into immunohistochemical subtypes, 8.5 % were classified as HER2, 20.5 % were classified as basal, and 70.5 % were classified as luminal. Fig. 2 shows K-M survival curves for the association between the Menacalc status (high vs. low) and survival in the three main subtype groups: HER2 (n = 20), basal (n = 48) and luminal (n = 165). Although the subtype tests of association did not attain nominal 5 % significance, the plots show the same trend of high Menacalc association with worse survival.Fig. 2


Menacalc, a quantitative method of metastasis assessment, as a prognostic marker for axillary node-negative breast cancer.

Forse CL, Agarwal S, Pinnaduwage D, Gertler F, Condeelis JS, Lin J, Xue X, Johung K, Mulligan AM, Rohan TE, Bull SB, Andrulis IL - BMC Cancer (2015)

Kaplan-Meier analysis of Menacalc for ANN tumors subclassified by immunohistochemical subtype: HER2 amplified (n = 20, top left), basal (n = 48, top right) and luminal (n = 165, bottom left). In brackets is the total number of patients followed by the number of patient deaths for each group
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4482190&req=5

Fig2: Kaplan-Meier analysis of Menacalc for ANN tumors subclassified by immunohistochemical subtype: HER2 amplified (n = 20, top left), basal (n = 48, top right) and luminal (n = 165, bottom left). In brackets is the total number of patients followed by the number of patient deaths for each group
Mentions: When the tumors were subdivided into immunohistochemical subtypes, 8.5 % were classified as HER2, 20.5 % were classified as basal, and 70.5 % were classified as luminal. Fig. 2 shows K-M survival curves for the association between the Menacalc status (high vs. low) and survival in the three main subtype groups: HER2 (n = 20), basal (n = 48) and luminal (n = 165). Although the subtype tests of association did not attain nominal 5 % significance, the plots show the same trend of high Menacalc association with worse survival.Fig. 2

Bottom Line: High Menacalc was associated with increased risk of death from any cause (P=0.0199, HR (CI)=2.18 (1.19, 4.00)).A similarly elevated risk of death was found in the subset of the Menacalc cohort which did not receive hormone or chemotherapy (n=142) (P=0.0052, HR (CI)=3.80 (1.58, 9.97)).There was a trend toward increased risk of death with relatively high Menacalc in the HER2, basal and luminal molecular subtypes.

View Article: PubMed Central - PubMed

Affiliation: Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada. catherine.forse@mail.utoronto.ca.

ABSTRACT

Background: Menacalc is an immunofluorescence-based, quantitative method in which expression of the non-invasive Mena protein isoform (Mena11a) is subtracted from total Mena protein expression. Previous work has found a significant positive association between Menacalc and risk of death from breast cancer. Our goal was to determine if Menacalc could be used as an independent prognostic marker for axillary node-negative (ANN) breast cancer.

Methods: Analysis of the association of Menacalc with overall survival (death from any cause) was performed for 403 ANN tumors using Kaplan Meier survival curves and the univariate Cox proportional hazards (PH) model with the log-rank or the likelihood ratio test. Cox PH models were used to estimate hazard ratios (HRs) for the association of Menacalc with risk of death after adjustment for HER2 status and clinicopathological tumor features.

Results: High Menacalc was associated with increased risk of death from any cause (P=0.0199, HR (CI)=2.18 (1.19, 4.00)). A similarly elevated risk of death was found in the subset of the Menacalc cohort which did not receive hormone or chemotherapy (n=142) (P=0.0052, HR (CI)=3.80 (1.58, 9.97)). There was a trend toward increased risk of death with relatively high Menacalc in the HER2, basal and luminal molecular subtypes.

Conclusions: Menacalc may serve as an independent prognostic biomarker for the ANN breast cancer patient population.

No MeSH data available.


Related in: MedlinePlus