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Potential harmful health effects of inhaling nicotine-free shisha-pen vapor: a chemical risk assessment of the main components propylene glycol and glycerol.

Kienhuis AS, Soeteman-Hernandez LG, Bos PM, Cremers HW, Klerx WN, Talhout R - Tob Induc Dis (2015)

Bottom Line: The aim of this study was to assess the potential harmful health effects caused by inhaling the vapor of a nicotine-free shisha-pen.The concentrations that reached the airways and lungs after using a shisha-pen were calculated and compared to data from published toxicity studies.New products such as the shisha-pen should be detected and risks should be assessed to inform regulatory actions aimed at limiting potential harm that may be caused to consumers and protecting young people to take up smoking.

View Article: PubMed Central - PubMed

Affiliation: National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA Bilthoven, The Netherlands.

ABSTRACT

Background: A shisha-pen is an electronic cigarette variant that is advertised to mimic the taste of a water pipe, or shisha. The aim of this study was to assess the potential harmful health effects caused by inhaling the vapor of a nicotine-free shisha-pen.

Methods: Gas chromatography analysis was performed to determine the major components in shisha-pen vapor. Risk assessment was performed using puff volumes of e-cigarettes and "normal" cigarettes and a 1-puff scenario (one-time exposure). The concentrations that reached the airways and lungs after using a shisha-pen were calculated and compared to data from published toxicity studies.

Results: The main components in shisha-pen vapor are propylene glycol and glycerol (54%/46%). One puff (50 to 70 mL) results in exposure of propylene glycol and glycerol of 430 to 603 mg/m(3) and 348 to 495 mg/m(3), respectively. These exposure concentrations were higher than the points of departure for airway irritation based on a human study (propylene glycol, mean concentration of 309 mg/m(3)) and a rat study (glycerol, no-observed adverse effect level of 165 mg/m(3)).

Conclusions: Already after one puff of the shisha-pen, the concentrations of propylene glycol and glycerol are sufficiently high to potentially cause irritation of the airways. New products such as the shisha-pen should be detected and risks should be assessed to inform regulatory actions aimed at limiting potential harm that may be caused to consumers and protecting young people to take up smoking.

No MeSH data available.


Related in: MedlinePlus

Shisha-pen, apple flavor.
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Related In: Results  -  Collection

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Fig1: Shisha-pen, apple flavor.

Mentions: A shisha-pen is a pen that has a bulb in the shape of a diamond in one end and a mouthpiece with a small nozzle hole in the other end (Figure 1). The casing includes an electrical circuit with a battery and a coil that is coupled via a wire to a gauze pad soaked in liquid. When sucking on the mouthpiece, the electrical circuit is closed and the small wire connected to the gauze pad becomes warm, additionally the shisha-pen lamp is activated and lights up. As soon as the coil is heated, the liquid evaporates generating vapor which is inhaled. When air is no longer sucked in via the mouthpiece, the electronic circuit is interrupted and the wire cools down and the lamp turns off. The shisha-pen is ready for the next “air pull” via the mouthpiece until all the liquid in the gauze is evaporated. A dismantled shisha-pen is shown in Figure 2.Figure 1


Potential harmful health effects of inhaling nicotine-free shisha-pen vapor: a chemical risk assessment of the main components propylene glycol and glycerol.

Kienhuis AS, Soeteman-Hernandez LG, Bos PM, Cremers HW, Klerx WN, Talhout R - Tob Induc Dis (2015)

Shisha-pen, apple flavor.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4482188&req=5

Fig1: Shisha-pen, apple flavor.
Mentions: A shisha-pen is a pen that has a bulb in the shape of a diamond in one end and a mouthpiece with a small nozzle hole in the other end (Figure 1). The casing includes an electrical circuit with a battery and a coil that is coupled via a wire to a gauze pad soaked in liquid. When sucking on the mouthpiece, the electrical circuit is closed and the small wire connected to the gauze pad becomes warm, additionally the shisha-pen lamp is activated and lights up. As soon as the coil is heated, the liquid evaporates generating vapor which is inhaled. When air is no longer sucked in via the mouthpiece, the electronic circuit is interrupted and the wire cools down and the lamp turns off. The shisha-pen is ready for the next “air pull” via the mouthpiece until all the liquid in the gauze is evaporated. A dismantled shisha-pen is shown in Figure 2.Figure 1

Bottom Line: The aim of this study was to assess the potential harmful health effects caused by inhaling the vapor of a nicotine-free shisha-pen.The concentrations that reached the airways and lungs after using a shisha-pen were calculated and compared to data from published toxicity studies.New products such as the shisha-pen should be detected and risks should be assessed to inform regulatory actions aimed at limiting potential harm that may be caused to consumers and protecting young people to take up smoking.

View Article: PubMed Central - PubMed

Affiliation: National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA Bilthoven, The Netherlands.

ABSTRACT

Background: A shisha-pen is an electronic cigarette variant that is advertised to mimic the taste of a water pipe, or shisha. The aim of this study was to assess the potential harmful health effects caused by inhaling the vapor of a nicotine-free shisha-pen.

Methods: Gas chromatography analysis was performed to determine the major components in shisha-pen vapor. Risk assessment was performed using puff volumes of e-cigarettes and "normal" cigarettes and a 1-puff scenario (one-time exposure). The concentrations that reached the airways and lungs after using a shisha-pen were calculated and compared to data from published toxicity studies.

Results: The main components in shisha-pen vapor are propylene glycol and glycerol (54%/46%). One puff (50 to 70 mL) results in exposure of propylene glycol and glycerol of 430 to 603 mg/m(3) and 348 to 495 mg/m(3), respectively. These exposure concentrations were higher than the points of departure for airway irritation based on a human study (propylene glycol, mean concentration of 309 mg/m(3)) and a rat study (glycerol, no-observed adverse effect level of 165 mg/m(3)).

Conclusions: Already after one puff of the shisha-pen, the concentrations of propylene glycol and glycerol are sufficiently high to potentially cause irritation of the airways. New products such as the shisha-pen should be detected and risks should be assessed to inform regulatory actions aimed at limiting potential harm that may be caused to consumers and protecting young people to take up smoking.

No MeSH data available.


Related in: MedlinePlus