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Prenatal Alcohol Exposure and Congenital Heart Defects: A Meta-Analysis.

Yang J, Qiu H, Qu P, Zhang R, Zeng L, Yan H - PLoS ONE (2015)

Bottom Line: There are still inconsistent conclusions about the association of prenatal alcohol drinking with congenital heart defects (CHDs).The pooled ORs and 95%CI were estimated using the random-effects model and heterogeneity was assessed by the Q test and I2 statistic.In conclusion, the results suggested that prenatal alcohol exposure was not associated with overall CHDs or some subtypes, whereas marginally significant association was found for CTDs and statistically significant association was found for dTGA.

View Article: PubMed Central - PubMed

Affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, People's Republic of China.

ABSTRACT

Background: There are still inconsistent conclusions about the association of prenatal alcohol drinking with congenital heart defects (CHDs). We conducted this meta-analysis to investigate the association between prenatal alcohol exposure and the risk of overall CHDs and the CHDs subtypes.

Methods: Case-control and cohort studies published before March 2015 were searched through PubMed and Embase. Two authors independently extracted data and scored the study quality according to the Newcastle-0ttawa Scale. The pooled ORs and 95%CI were estimated using the random-effects model and heterogeneity was assessed by the Q test and I2 statistic.

Results: A total of 20 studies were finally included. The results provided no evidence of the association between prenatal alcohol exposure and the risk of overall CHDs (OR = 1.06, 95%CI = 0.93-1.22), ventricular septal defects (VSDs) (OR = 1.04, 95%CI = 0.86-1.25), or atrial septal defects (ASDs) (OR = 1.40, 95%CI = 0.88-2.23). However, prenatal alcohol drinking was marginally significantly associated with conotruncal defects (CTDs) (OR = 1.24, 95%CI = 0.97-1.59) and statistically significantly associated with d-Transposition of the Great Arteries (dTGA) (OR = 1.64, 95%CI = 1.17-2.30). Moreover, both prenatal heavy drinking and binge drinking have a strong association with overall CHDs (heavy drinking: OR = 3.76, 95%CI = 1.00-14.10; binge drinking: OR = 2.49, 95%CI = 1.04-5.97), and prenatal moderate drinking has a modest association with CTDs (OR = 1.35, 95%CI = 1.05-1.75) and dTGA (OR = 1.86, 95%CI = 1.09-3.20).

Conclusions: In conclusion, the results suggested that prenatal alcohol exposure was not associated with overall CHDs or some subtypes, whereas marginally significant association was found for CTDs and statistically significant association was found for dTGA. Further prospective studies with large population and better designs are needed to explore the association of prenatal alcohol exposure with CHDs including the subtypes in specific groups.

No MeSH data available.


Related in: MedlinePlus

Forest plot of any prenatal alcohol exposure and overall congenital heart defects risk.
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pone.0130681.g002: Forest plot of any prenatal alcohol exposure and overall congenital heart defects risk.

Mentions: The relationship between prenatal alcohol exposure and overall CHDs was investigated in 8 studies, with a total number of 3,749 cases and 122,200 controls. The pooled result suggested that prenatal alcohol drinking seemed to slightly increase overall CHDs risk, but the confidence interval included unity (OR = 1.06, 95%CI = 0.93–1.22) (Fig 2). No significant heterogeneity among studies was found (P = 0.10, I2 = 42.1%). Subgroup analyses stratified by geographical area, study type, timing of drinking, or publication year yielded no significant association (Table 1). However, a borderline significantly higher risk of overall CHDs associated with prenatal alcohol intake was found in studies with sample size larger than 1,000 (OR = 1.11, 95%CI = 0.96–1.29).


Prenatal Alcohol Exposure and Congenital Heart Defects: A Meta-Analysis.

Yang J, Qiu H, Qu P, Zhang R, Zeng L, Yan H - PLoS ONE (2015)

Forest plot of any prenatal alcohol exposure and overall congenital heart defects risk.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4482023&req=5

pone.0130681.g002: Forest plot of any prenatal alcohol exposure and overall congenital heart defects risk.
Mentions: The relationship between prenatal alcohol exposure and overall CHDs was investigated in 8 studies, with a total number of 3,749 cases and 122,200 controls. The pooled result suggested that prenatal alcohol drinking seemed to slightly increase overall CHDs risk, but the confidence interval included unity (OR = 1.06, 95%CI = 0.93–1.22) (Fig 2). No significant heterogeneity among studies was found (P = 0.10, I2 = 42.1%). Subgroup analyses stratified by geographical area, study type, timing of drinking, or publication year yielded no significant association (Table 1). However, a borderline significantly higher risk of overall CHDs associated with prenatal alcohol intake was found in studies with sample size larger than 1,000 (OR = 1.11, 95%CI = 0.96–1.29).

Bottom Line: There are still inconsistent conclusions about the association of prenatal alcohol drinking with congenital heart defects (CHDs).The pooled ORs and 95%CI were estimated using the random-effects model and heterogeneity was assessed by the Q test and I2 statistic.In conclusion, the results suggested that prenatal alcohol exposure was not associated with overall CHDs or some subtypes, whereas marginally significant association was found for CTDs and statistically significant association was found for dTGA.

View Article: PubMed Central - PubMed

Affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, People's Republic of China.

ABSTRACT

Background: There are still inconsistent conclusions about the association of prenatal alcohol drinking with congenital heart defects (CHDs). We conducted this meta-analysis to investigate the association between prenatal alcohol exposure and the risk of overall CHDs and the CHDs subtypes.

Methods: Case-control and cohort studies published before March 2015 were searched through PubMed and Embase. Two authors independently extracted data and scored the study quality according to the Newcastle-0ttawa Scale. The pooled ORs and 95%CI were estimated using the random-effects model and heterogeneity was assessed by the Q test and I2 statistic.

Results: A total of 20 studies were finally included. The results provided no evidence of the association between prenatal alcohol exposure and the risk of overall CHDs (OR = 1.06, 95%CI = 0.93-1.22), ventricular septal defects (VSDs) (OR = 1.04, 95%CI = 0.86-1.25), or atrial septal defects (ASDs) (OR = 1.40, 95%CI = 0.88-2.23). However, prenatal alcohol drinking was marginally significantly associated with conotruncal defects (CTDs) (OR = 1.24, 95%CI = 0.97-1.59) and statistically significantly associated with d-Transposition of the Great Arteries (dTGA) (OR = 1.64, 95%CI = 1.17-2.30). Moreover, both prenatal heavy drinking and binge drinking have a strong association with overall CHDs (heavy drinking: OR = 3.76, 95%CI = 1.00-14.10; binge drinking: OR = 2.49, 95%CI = 1.04-5.97), and prenatal moderate drinking has a modest association with CTDs (OR = 1.35, 95%CI = 1.05-1.75) and dTGA (OR = 1.86, 95%CI = 1.09-3.20).

Conclusions: In conclusion, the results suggested that prenatal alcohol exposure was not associated with overall CHDs or some subtypes, whereas marginally significant association was found for CTDs and statistically significant association was found for dTGA. Further prospective studies with large population and better designs are needed to explore the association of prenatal alcohol exposure with CHDs including the subtypes in specific groups.

No MeSH data available.


Related in: MedlinePlus