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Are Lipases Still Important Biocatalysts? A Study of Scientific Publications and Patents for Technological Forecasting.

Daiha Kde G, Angeli R, de Oliveira SD, Almeida RV - PLoS ONE (2015)

Bottom Line: Haldane was published.After eighty-five years of studies and developments, are lipases still important biocatalysts?Applying the concept of technology life cycle, S-curves were built by plotting cumulative patent data over time to monitor the attractiveness of each technology for investment.

View Article: PubMed Central - PubMed

Affiliation: Departamento de Bioquímica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil.

ABSTRACT
The great potential of lipases is known since 1930 when the work of J. B. S. Haldane was published. After eighty-five years of studies and developments, are lipases still important biocatalysts? For answering this question the present work investigated the technological development of four important industrial sectors where lipases are applied: production of detergent formulations; organic synthesis, focusing on kinetic resolution, production of biodiesel, and production of food and feed products. The analysis was made based on research publications and patent applications, working as scientific and technological indicators, respectively. Their evolution, interaction, the major players of each sector and the main subject matters disclosed in patent documents were discussed. Applying the concept of technology life cycle, S-curves were built by plotting cumulative patent data over time to monitor the attractiveness of each technology for investment. The results lead to a conclusion that the use of lipases as biocatalysts is still a relevant topic for the industrial sector, but developments are still needed for lipase biocatalysis to reach its full potential, which are expected to be achieved within the third, and present, wave of biocatalysis.

No MeSH data available.


Related in: MedlinePlus

Cumulative patent data fitted into S-shaped curves using Loglet Lab 2 Software.Growth trajectories of lipase and A) kinetic resolution technology; B) detergent production technology; C) food and feed production technology; and D) biodiesel production technology.
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pone.0131624.g007: Cumulative patent data fitted into S-shaped curves using Loglet Lab 2 Software.Growth trajectories of lipase and A) kinetic resolution technology; B) detergent production technology; C) food and feed production technology; and D) biodiesel production technology.

Mentions: In the case of racemic resolution (Fig 7A), the first growth pulse overlaps the Japanese progress in filing patent applications related to such technology. It started in 1986, reached the midpoint in 1991 and matured in 1995. The above stages respectively correspond to 10%, 50% and 90% of the growth limit. The second growth pulse started in 1992, possibly associated with the Japanese crisis and participation of other players in the filing of patent applications. The midpoint and mature year were respectively reached in 2002 and 2012.


Are Lipases Still Important Biocatalysts? A Study of Scientific Publications and Patents for Technological Forecasting.

Daiha Kde G, Angeli R, de Oliveira SD, Almeida RV - PLoS ONE (2015)

Cumulative patent data fitted into S-shaped curves using Loglet Lab 2 Software.Growth trajectories of lipase and A) kinetic resolution technology; B) detergent production technology; C) food and feed production technology; and D) biodiesel production technology.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4482018&req=5

pone.0131624.g007: Cumulative patent data fitted into S-shaped curves using Loglet Lab 2 Software.Growth trajectories of lipase and A) kinetic resolution technology; B) detergent production technology; C) food and feed production technology; and D) biodiesel production technology.
Mentions: In the case of racemic resolution (Fig 7A), the first growth pulse overlaps the Japanese progress in filing patent applications related to such technology. It started in 1986, reached the midpoint in 1991 and matured in 1995. The above stages respectively correspond to 10%, 50% and 90% of the growth limit. The second growth pulse started in 1992, possibly associated with the Japanese crisis and participation of other players in the filing of patent applications. The midpoint and mature year were respectively reached in 2002 and 2012.

Bottom Line: Haldane was published.After eighty-five years of studies and developments, are lipases still important biocatalysts?Applying the concept of technology life cycle, S-curves were built by plotting cumulative patent data over time to monitor the attractiveness of each technology for investment.

View Article: PubMed Central - PubMed

Affiliation: Departamento de Bioquímica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil.

ABSTRACT
The great potential of lipases is known since 1930 when the work of J. B. S. Haldane was published. After eighty-five years of studies and developments, are lipases still important biocatalysts? For answering this question the present work investigated the technological development of four important industrial sectors where lipases are applied: production of detergent formulations; organic synthesis, focusing on kinetic resolution, production of biodiesel, and production of food and feed products. The analysis was made based on research publications and patent applications, working as scientific and technological indicators, respectively. Their evolution, interaction, the major players of each sector and the main subject matters disclosed in patent documents were discussed. Applying the concept of technology life cycle, S-curves were built by plotting cumulative patent data over time to monitor the attractiveness of each technology for investment. The results lead to a conclusion that the use of lipases as biocatalysts is still a relevant topic for the industrial sector, but developments are still needed for lipase biocatalysis to reach its full potential, which are expected to be achieved within the third, and present, wave of biocatalysis.

No MeSH data available.


Related in: MedlinePlus