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Enhanced sensitive love wave surface acoustic wave sensor designed for immunoassay formats.

Puiu M, Gurban AM, Rotariu L, Brajnicov S, Viespe C, Bala C - Sensors (Basel) (2015)

Bottom Line: We report a Love wave surface acoustic wave (LW-SAW) immunosensor designed for the detection of high molecular weight targets in liquid samples, amenable also for low molecular targets in surface competition assays.We implemented a label-free interaction protocol similar to other surface plasmon resonance bioassays having the advantage of requiring reduced time analysis.The fabricated LW-SAW sensor supports the detection of the target in the nanomolar range, and can be ultimately incorporated in portable devices, suitable for point-of-care testing (POCT) applications.

View Article: PubMed Central - PubMed

Affiliation: LaborQ, University of Bucharest, 4-12 Regina Elisabeta Blvd., 030018 Bucharest, Romania. elenamihaela.puiu@g.unibuc.ro.

ABSTRACT
We report a Love wave surface acoustic wave (LW-SAW) immunosensor designed for the detection of high molecular weight targets in liquid samples, amenable also for low molecular targets in surface competition assays. We implemented a label-free interaction protocol similar to other surface plasmon resonance bioassays having the advantage of requiring reduced time analysis. The fabricated LW-SAW sensor supports the detection of the target in the nanomolar range, and can be ultimately incorporated in portable devices, suitable for point-of-care testing (POCT) applications.

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Experimental setup used to characterize the LW-SAW resonator.
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sensors-15-10511-f002: Experimental setup used to characterize the LW-SAW resonator.

Mentions: Also, the measurements for antibody‚Äďantigen interaction and antibody immobilization were carried out with a LW-SAW device consisting in a piezoelectric substrate, input and output interdigital transducers, a waveguide layer, and a sensitive layer (Figure 1), together with the oscillating system (Figure 2).


Enhanced sensitive love wave surface acoustic wave sensor designed for immunoassay formats.

Puiu M, Gurban AM, Rotariu L, Brajnicov S, Viespe C, Bala C - Sensors (Basel) (2015)

Experimental setup used to characterize the LW-SAW resonator.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4481942&req=5

sensors-15-10511-f002: Experimental setup used to characterize the LW-SAW resonator.
Mentions: Also, the measurements for antibody‚Äďantigen interaction and antibody immobilization were carried out with a LW-SAW device consisting in a piezoelectric substrate, input and output interdigital transducers, a waveguide layer, and a sensitive layer (Figure 1), together with the oscillating system (Figure 2).

Bottom Line: We report a Love wave surface acoustic wave (LW-SAW) immunosensor designed for the detection of high molecular weight targets in liquid samples, amenable also for low molecular targets in surface competition assays.We implemented a label-free interaction protocol similar to other surface plasmon resonance bioassays having the advantage of requiring reduced time analysis.The fabricated LW-SAW sensor supports the detection of the target in the nanomolar range, and can be ultimately incorporated in portable devices, suitable for point-of-care testing (POCT) applications.

View Article: PubMed Central - PubMed

Affiliation: LaborQ, University of Bucharest, 4-12 Regina Elisabeta Blvd., 030018 Bucharest, Romania. elenamihaela.puiu@g.unibuc.ro.

ABSTRACT
We report a Love wave surface acoustic wave (LW-SAW) immunosensor designed for the detection of high molecular weight targets in liquid samples, amenable also for low molecular targets in surface competition assays. We implemented a label-free interaction protocol similar to other surface plasmon resonance bioassays having the advantage of requiring reduced time analysis. The fabricated LW-SAW sensor supports the detection of the target in the nanomolar range, and can be ultimately incorporated in portable devices, suitable for point-of-care testing (POCT) applications.

Show MeSH