Limits...
Fabrication and robotization of ultrasensitive plasmonic nanosensors for molecule detection with Raman scattering.

Xu X, Kim K, Liu C, Fan D - Sensors (Basel) (2015)

Bottom Line: Our nanosensors, consisting of tri-layer nanocapsule structures, are ultrasensitive, well reproducible, and can be robotized by either electric or magnetic tweezers.Three applications using such SERS nanosensors were demonstrated, including location predictable detection, single-cell bioanalysis, and tunable molecule release and monitoring.The integration of SERS and nanoelectromechanical system (NEMS) devices is innovative in both device concept and fabrication, and could potentially inspire a new device scheme for various bio-relevant applications.

View Article: PubMed Central - PubMed

Affiliation: Materials Science and Engineering Program, the University of Texas at Austin, Austin, TX 78712, USA. xxu.uta@gmail.com.

ABSTRACT
In this work, we introduce the history and mechanisms of surface enhanced Raman scattering (SERS), discuss various techniques for fabrication of state-of-the-art SERS substrates, and review recent work on robotizing plasmonic nanoparticles, especially, the efforts we made on fabrication, characterization, and robotization of Raman nanosensors by design. Our nanosensors, consisting of tri-layer nanocapsule structures, are ultrasensitive, well reproducible, and can be robotized by either electric or magnetic tweezers. Three applications using such SERS nanosensors were demonstrated, including location predictable detection, single-cell bioanalysis, and tunable molecule release and monitoring. The integration of SERS and nanoelectromechanical system (NEMS) devices is innovative in both device concept and fabrication, and could potentially inspire a new device scheme for various bio-relevant applications.

Show MeSH
Schematic diagram of molecule release from a rotary plasmonic nanomotor [105]. With permission from [105].
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4481927&req=5

sensors-15-10422-f016: Schematic diagram of molecule release from a rotary plasmonic nanomotor [105]. With permission from [105].

Mentions: Finally, the nanocapsules were assembled into rotary nanomotors. They were compelled to rotate with controlled angle, speed, and chirality for tunable molecule release and detection. The nanomotors consist of the nanocapsules as rotors, patterned nanomagnets as bearings, and the quadruple microelectrodes as stators (Figure 16) [105]. The electric tweezers were employed to assemble and actuate the rotary nanomotors. The assembling of the nanomotors were achieved by using the same technique employed for assembling nanocapsules into ordered arrays (Figure 14), where the nanocapsules were transported to anchor atop of the nanomagnets.


Fabrication and robotization of ultrasensitive plasmonic nanosensors for molecule detection with Raman scattering.

Xu X, Kim K, Liu C, Fan D - Sensors (Basel) (2015)

Schematic diagram of molecule release from a rotary plasmonic nanomotor [105]. With permission from [105].
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4481927&req=5

sensors-15-10422-f016: Schematic diagram of molecule release from a rotary plasmonic nanomotor [105]. With permission from [105].
Mentions: Finally, the nanocapsules were assembled into rotary nanomotors. They were compelled to rotate with controlled angle, speed, and chirality for tunable molecule release and detection. The nanomotors consist of the nanocapsules as rotors, patterned nanomagnets as bearings, and the quadruple microelectrodes as stators (Figure 16) [105]. The electric tweezers were employed to assemble and actuate the rotary nanomotors. The assembling of the nanomotors were achieved by using the same technique employed for assembling nanocapsules into ordered arrays (Figure 14), where the nanocapsules were transported to anchor atop of the nanomagnets.

Bottom Line: Our nanosensors, consisting of tri-layer nanocapsule structures, are ultrasensitive, well reproducible, and can be robotized by either electric or magnetic tweezers.Three applications using such SERS nanosensors were demonstrated, including location predictable detection, single-cell bioanalysis, and tunable molecule release and monitoring.The integration of SERS and nanoelectromechanical system (NEMS) devices is innovative in both device concept and fabrication, and could potentially inspire a new device scheme for various bio-relevant applications.

View Article: PubMed Central - PubMed

Affiliation: Materials Science and Engineering Program, the University of Texas at Austin, Austin, TX 78712, USA. xxu.uta@gmail.com.

ABSTRACT
In this work, we introduce the history and mechanisms of surface enhanced Raman scattering (SERS), discuss various techniques for fabrication of state-of-the-art SERS substrates, and review recent work on robotizing plasmonic nanoparticles, especially, the efforts we made on fabrication, characterization, and robotization of Raman nanosensors by design. Our nanosensors, consisting of tri-layer nanocapsule structures, are ultrasensitive, well reproducible, and can be robotized by either electric or magnetic tweezers. Three applications using such SERS nanosensors were demonstrated, including location predictable detection, single-cell bioanalysis, and tunable molecule release and monitoring. The integration of SERS and nanoelectromechanical system (NEMS) devices is innovative in both device concept and fabrication, and could potentially inspire a new device scheme for various bio-relevant applications.

Show MeSH