Limits...
Breast Tissue Composition and Immunophenotype and Its Relationship with Mammographic Density in Women at High Risk of Breast Cancer.

Pang JM, Byrne DJ, Takano EA, Jene N, Petelin L, McKinley J, Poliness C, Saunders C, Taylor D, Mitchell G, Fox SB - PLoS ONE (2015)

Bottom Line: Contrary to previous reports, stromal expression of ERα was common (19/20 cases, 95%).There was significantly higher stromal PgR expression in mammographically-dense breasts (p=0.026).Increased expression of PgR in the stroma of mammographically dense breasts and frequent and unexpected presence of stromal ERα expression raises the possibility that hormone receptor expression in breast stroma may have a role in mediating the effects of exogenous hormonal therapy on mammographic density.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia; Department of Pathology, University of Melbourne, Parkville, Melbourne, Victoria, Australia.

ABSTRACT

Aim: To investigate the cellular and immunophenotypic basis of mammographic density in women at high risk of breast cancer.

Methods: Mammograms and targeted breast biopsies were accrued from 24 women at high risk of breast cancer. Mammographic density was classified into Wolfe categories and ranked by increasing density. The histological composition and immunophenotypic profile were quantified from digitized haematoxylin and eosin-stained and immunohistochemically-stained (ERα, ERβ, PgR, HER2, Ki-67, and CD31) slides and correlated to mammographic density.

Results: Increasing mammographic density was significantly correlated with increased fibrous stroma proportion (rs (22) = 0.5226, p = 0.0088) and significantly inversely associated with adipose tissue proportion (rs (22) = -0.5409, p = 0.0064). Contrary to previous reports, stromal expression of ERα was common (19/20 cases, 95%). There was significantly higher stromal PgR expression in mammographically-dense breasts (p=0.026).

Conclusions: The proportion of stroma and fat underlies mammographic density in women at high risk of breast cancer. Increased expression of PgR in the stroma of mammographically dense breasts and frequent and unexpected presence of stromal ERα expression raises the possibility that hormone receptor expression in breast stroma may have a role in mediating the effects of exogenous hormonal therapy on mammographic density.

No MeSH data available.


Related in: MedlinePlus

Proportion of fibrous stroma, fat, epithelium, and vascular area by mammographic density rank.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4481506&req=5

pone.0128861.g003: Proportion of fibrous stroma, fat, epithelium, and vascular area by mammographic density rank.

Mentions: There was a significant positive correlation between increasing mammographic density rank and the proportion of fibrous stroma (rs (22) = 0.5226, p = 0.0088), and a significant inverse relationship between increasing density rank and percentage fat (rs (22) = -0.5409, p = 0.0064) (Table 1, Fig 3). No significant correlation between mammographic density and proportion of epithelium or vascular area (p>0.05) was identified (Table 1) nor between tissue composition and mammographic density as determined by Wolfe categories (p>0.05).


Breast Tissue Composition and Immunophenotype and Its Relationship with Mammographic Density in Women at High Risk of Breast Cancer.

Pang JM, Byrne DJ, Takano EA, Jene N, Petelin L, McKinley J, Poliness C, Saunders C, Taylor D, Mitchell G, Fox SB - PLoS ONE (2015)

Proportion of fibrous stroma, fat, epithelium, and vascular area by mammographic density rank.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4481506&req=5

pone.0128861.g003: Proportion of fibrous stroma, fat, epithelium, and vascular area by mammographic density rank.
Mentions: There was a significant positive correlation between increasing mammographic density rank and the proportion of fibrous stroma (rs (22) = 0.5226, p = 0.0088), and a significant inverse relationship between increasing density rank and percentage fat (rs (22) = -0.5409, p = 0.0064) (Table 1, Fig 3). No significant correlation between mammographic density and proportion of epithelium or vascular area (p>0.05) was identified (Table 1) nor between tissue composition and mammographic density as determined by Wolfe categories (p>0.05).

Bottom Line: Contrary to previous reports, stromal expression of ERα was common (19/20 cases, 95%).There was significantly higher stromal PgR expression in mammographically-dense breasts (p=0.026).Increased expression of PgR in the stroma of mammographically dense breasts and frequent and unexpected presence of stromal ERα expression raises the possibility that hormone receptor expression in breast stroma may have a role in mediating the effects of exogenous hormonal therapy on mammographic density.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia; Department of Pathology, University of Melbourne, Parkville, Melbourne, Victoria, Australia.

ABSTRACT

Aim: To investigate the cellular and immunophenotypic basis of mammographic density in women at high risk of breast cancer.

Methods: Mammograms and targeted breast biopsies were accrued from 24 women at high risk of breast cancer. Mammographic density was classified into Wolfe categories and ranked by increasing density. The histological composition and immunophenotypic profile were quantified from digitized haematoxylin and eosin-stained and immunohistochemically-stained (ERα, ERβ, PgR, HER2, Ki-67, and CD31) slides and correlated to mammographic density.

Results: Increasing mammographic density was significantly correlated with increased fibrous stroma proportion (rs (22) = 0.5226, p = 0.0088) and significantly inversely associated with adipose tissue proportion (rs (22) = -0.5409, p = 0.0064). Contrary to previous reports, stromal expression of ERα was common (19/20 cases, 95%). There was significantly higher stromal PgR expression in mammographically-dense breasts (p=0.026).

Conclusions: The proportion of stroma and fat underlies mammographic density in women at high risk of breast cancer. Increased expression of PgR in the stroma of mammographically dense breasts and frequent and unexpected presence of stromal ERα expression raises the possibility that hormone receptor expression in breast stroma may have a role in mediating the effects of exogenous hormonal therapy on mammographic density.

No MeSH data available.


Related in: MedlinePlus