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Susceptibility-weighted imaging provides insight into white matter damage in amyotrophic lateral sclerosis.

Prell T, Hartung V, Tietz F, Penzlin S, Ilse B, Schweser F, Deistung A, Bokemeyer M, Reichenbach JR, Witte OW, Grosskreutz J - PLoS ONE (2015)

Bottom Line: Signal alterations were found on SWI in the corpus callosum; along the corticospinal tract (subcortical motor cortex, posterior limb of the internal capsule and brainstem levels) and in the subgyral regions of frontal, parietal, temporal, occipital and limbic lobes.Alterations of white matter in the corpus callosum correlated with disease severity as assessed by the revised ALS functional rating scale.The SWI patterns observed in this study suggest that widespread alterations due to iron disturbances occur in patients with ALS and correlate with disease severity.

View Article: PubMed Central - PubMed

Affiliation: Hans-Berger Department of Neurology, Jena University Hospital, Erlanger Allee 101, 07747, Jena, Germany.

ABSTRACT

Background: Amyotrophic lateral sclerosis (ALS) is a fatal, progressive neurodegenerative disorder, characterised by widespread white matter damage. There is growing evidence that disturbances in iron metabolism contribute to white matter alterations.

Materials & methods: We analysed the data of susceptibility-weighted imaging (SWI) of white matter in a cohort of 27 patients with ALS and 30 healthy age-matched controls.

Results: Signal alterations were found on SWI in the corpus callosum; along the corticospinal tract (subcortical motor cortex, posterior limb of the internal capsule and brainstem levels) and in the subgyral regions of frontal, parietal, temporal, occipital and limbic lobes. Alterations of white matter in the corpus callosum correlated with disease severity as assessed by the revised ALS functional rating scale.

Conclusion: SWI is capable of indicating iron and myelin disturbances in white matter of ALS patients. The SWI patterns observed in this study suggest that widespread alterations due to iron disturbances occur in patients with ALS and correlate with disease severity.

No MeSH data available.


Related in: MedlinePlus

Group comparison of SWI images between ALS patients and healthy controls.ALS patients showed lower SWI signal in deep white matter tracts, including corpus callosum, corticospinal and superior longitudinal fascicle most prominent in its frontal parts. The statistical parametric maps are displayed at a threshold P < 0.05 and corrected for multiple comparisons using FWE.
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pone.0131114.g002: Group comparison of SWI images between ALS patients and healthy controls.ALS patients showed lower SWI signal in deep white matter tracts, including corpus callosum, corticospinal and superior longitudinal fascicle most prominent in its frontal parts. The statistical parametric maps are displayed at a threshold P < 0.05 and corrected for multiple comparisons using FWE.

Mentions: Patients with ALS showed significantly lower SWI signal intensity in the deep white matter tracts along the whole CST ranging from the pre- and postcentral gyri throughout the posterior limb of the internal capsule until the brainstem. Regional differences between patients with ALS and healthy controls were also observed in the superior and inferior longitudinal fasciculus, anterior thalamic radiation, cingulum, the splenium and body of the corpus callosum, as well as in the inferior fronto-occipital fasciculus (Fig 2).


Susceptibility-weighted imaging provides insight into white matter damage in amyotrophic lateral sclerosis.

Prell T, Hartung V, Tietz F, Penzlin S, Ilse B, Schweser F, Deistung A, Bokemeyer M, Reichenbach JR, Witte OW, Grosskreutz J - PLoS ONE (2015)

Group comparison of SWI images between ALS patients and healthy controls.ALS patients showed lower SWI signal in deep white matter tracts, including corpus callosum, corticospinal and superior longitudinal fascicle most prominent in its frontal parts. The statistical parametric maps are displayed at a threshold P < 0.05 and corrected for multiple comparisons using FWE.
© Copyright Policy
Related In: Results  -  Collection

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Show All Figures
getmorefigures.php?uid=PMC4481412&req=5

pone.0131114.g002: Group comparison of SWI images between ALS patients and healthy controls.ALS patients showed lower SWI signal in deep white matter tracts, including corpus callosum, corticospinal and superior longitudinal fascicle most prominent in its frontal parts. The statistical parametric maps are displayed at a threshold P < 0.05 and corrected for multiple comparisons using FWE.
Mentions: Patients with ALS showed significantly lower SWI signal intensity in the deep white matter tracts along the whole CST ranging from the pre- and postcentral gyri throughout the posterior limb of the internal capsule until the brainstem. Regional differences between patients with ALS and healthy controls were also observed in the superior and inferior longitudinal fasciculus, anterior thalamic radiation, cingulum, the splenium and body of the corpus callosum, as well as in the inferior fronto-occipital fasciculus (Fig 2).

Bottom Line: Signal alterations were found on SWI in the corpus callosum; along the corticospinal tract (subcortical motor cortex, posterior limb of the internal capsule and brainstem levels) and in the subgyral regions of frontal, parietal, temporal, occipital and limbic lobes.Alterations of white matter in the corpus callosum correlated with disease severity as assessed by the revised ALS functional rating scale.The SWI patterns observed in this study suggest that widespread alterations due to iron disturbances occur in patients with ALS and correlate with disease severity.

View Article: PubMed Central - PubMed

Affiliation: Hans-Berger Department of Neurology, Jena University Hospital, Erlanger Allee 101, 07747, Jena, Germany.

ABSTRACT

Background: Amyotrophic lateral sclerosis (ALS) is a fatal, progressive neurodegenerative disorder, characterised by widespread white matter damage. There is growing evidence that disturbances in iron metabolism contribute to white matter alterations.

Materials & methods: We analysed the data of susceptibility-weighted imaging (SWI) of white matter in a cohort of 27 patients with ALS and 30 healthy age-matched controls.

Results: Signal alterations were found on SWI in the corpus callosum; along the corticospinal tract (subcortical motor cortex, posterior limb of the internal capsule and brainstem levels) and in the subgyral regions of frontal, parietal, temporal, occipital and limbic lobes. Alterations of white matter in the corpus callosum correlated with disease severity as assessed by the revised ALS functional rating scale.

Conclusion: SWI is capable of indicating iron and myelin disturbances in white matter of ALS patients. The SWI patterns observed in this study suggest that widespread alterations due to iron disturbances occur in patients with ALS and correlate with disease severity.

No MeSH data available.


Related in: MedlinePlus