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Characterizing longitudinal white matter development during early childhood.

Dean DC, O'Muircheartaigh J, Dirks H, Waskiewicz N, Walker L, Doernberg E, Piryatinsky I, Deoni SC - Brain Struct Funct (2014)

Bottom Line: Using nonlinear mixed effects modeling, we provide the first in vivo longitudinal description of myelin water fraction development.Moreover, we show distinct male and female developmental patterns, and demonstrate significant relationships between myelin content and measures of cognitive function.These findings advance a new understanding of healthy brain development and provide a foundation from which to assess atypical development.

View Article: PubMed Central - PubMed

Affiliation: Advanced Baby Imaging Laboratory, School of Engineering, Brown University, Providence, RI, 02912, USA, douglas_dean_iii@brown.edu.

ABSTRACT
Post-mortem studies have shown the maturation of the brain's myelinated white matter, crucial for efficient and coordinated brain communication, follows a nonlinear spatio-temporal pattern that corresponds with the onset and refinement of cognitive functions and behaviors. Unfortunately, investigation of myelination in vivo is challenging and, thus, little is known about the normative pattern of myelination, or its association with functional development. Using a novel quantitative magnetic resonance imaging technique sensitive to myelin we examined longitudinal white matter development in 108 typically developing children ranging in age from 2.5 months to 5.5 years. Using nonlinear mixed effects modeling, we provide the first in vivo longitudinal description of myelin water fraction development. Moreover, we show distinct male and female developmental patterns, and demonstrate significant relationships between myelin content and measures of cognitive function. These findings advance a new understanding of healthy brain development and provide a foundation from which to assess atypical development.

No MeSH data available.


Top row: change in visual reception, gross motor, and receptive language Mullen scales of early learning assessment scores as a function of changing VFM for the thalamus. The change in cognitive assessment scores were found to significantly correlate with changing VFM, suggesting concomitant structure–function development. Bottom row: illustrative moving average correlations (Pearson’s r, y-axis) as a function of mean age (days, x-axis) for the thalamus. Plots demonstrate the dynamic relationships between  and fine motor and expressive language ΔM. The age range at which these relationships transition appears to overlap with changes in the VFM and ∂t VFM trajectories
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Fig6: Top row: change in visual reception, gross motor, and receptive language Mullen scales of early learning assessment scores as a function of changing VFM for the thalamus. The change in cognitive assessment scores were found to significantly correlate with changing VFM, suggesting concomitant structure–function development. Bottom row: illustrative moving average correlations (Pearson’s r, y-axis) as a function of mean age (days, x-axis) for the thalamus. Plots demonstrate the dynamic relationships between and fine motor and expressive language ΔM. The age range at which these relationships transition appears to overlap with changes in the VFM and ∂t VFM trajectories

Mentions: Longitudinal changes VFM were found to significantly (p < 0.05, corrected for multiple comparisons) correlate with changes in Mullen assessment scores. Representative plots illustrating the positive relationship between the change in VFM and the change in Mullen assessment scores are shown in the top row of Fig. 6 for the thalamus. Gross motor scores were correlated with VFM in areas of the basal ganglia, thalamus, cerebellum, and other core white matter tracts, while measures of visual reception were correlated with VFM in the posterior limb of the internal capsule, superior corona radiata, and the superior longitudinal fasciculus. Changes in receptive language scores were also correlated with changes in VFM in the cerebellum, thalamus, occipital white matter, and posterior thalamic radiations.Fig. 6


Characterizing longitudinal white matter development during early childhood.

Dean DC, O'Muircheartaigh J, Dirks H, Waskiewicz N, Walker L, Doernberg E, Piryatinsky I, Deoni SC - Brain Struct Funct (2014)

Top row: change in visual reception, gross motor, and receptive language Mullen scales of early learning assessment scores as a function of changing VFM for the thalamus. The change in cognitive assessment scores were found to significantly correlate with changing VFM, suggesting concomitant structure–function development. Bottom row: illustrative moving average correlations (Pearson’s r, y-axis) as a function of mean age (days, x-axis) for the thalamus. Plots demonstrate the dynamic relationships between  and fine motor and expressive language ΔM. The age range at which these relationships transition appears to overlap with changes in the VFM and ∂t VFM trajectories
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4481335&req=5

Fig6: Top row: change in visual reception, gross motor, and receptive language Mullen scales of early learning assessment scores as a function of changing VFM for the thalamus. The change in cognitive assessment scores were found to significantly correlate with changing VFM, suggesting concomitant structure–function development. Bottom row: illustrative moving average correlations (Pearson’s r, y-axis) as a function of mean age (days, x-axis) for the thalamus. Plots demonstrate the dynamic relationships between and fine motor and expressive language ΔM. The age range at which these relationships transition appears to overlap with changes in the VFM and ∂t VFM trajectories
Mentions: Longitudinal changes VFM were found to significantly (p < 0.05, corrected for multiple comparisons) correlate with changes in Mullen assessment scores. Representative plots illustrating the positive relationship between the change in VFM and the change in Mullen assessment scores are shown in the top row of Fig. 6 for the thalamus. Gross motor scores were correlated with VFM in areas of the basal ganglia, thalamus, cerebellum, and other core white matter tracts, while measures of visual reception were correlated with VFM in the posterior limb of the internal capsule, superior corona radiata, and the superior longitudinal fasciculus. Changes in receptive language scores were also correlated with changes in VFM in the cerebellum, thalamus, occipital white matter, and posterior thalamic radiations.Fig. 6

Bottom Line: Using nonlinear mixed effects modeling, we provide the first in vivo longitudinal description of myelin water fraction development.Moreover, we show distinct male and female developmental patterns, and demonstrate significant relationships between myelin content and measures of cognitive function.These findings advance a new understanding of healthy brain development and provide a foundation from which to assess atypical development.

View Article: PubMed Central - PubMed

Affiliation: Advanced Baby Imaging Laboratory, School of Engineering, Brown University, Providence, RI, 02912, USA, douglas_dean_iii@brown.edu.

ABSTRACT
Post-mortem studies have shown the maturation of the brain's myelinated white matter, crucial for efficient and coordinated brain communication, follows a nonlinear spatio-temporal pattern that corresponds with the onset and refinement of cognitive functions and behaviors. Unfortunately, investigation of myelination in vivo is challenging and, thus, little is known about the normative pattern of myelination, or its association with functional development. Using a novel quantitative magnetic resonance imaging technique sensitive to myelin we examined longitudinal white matter development in 108 typically developing children ranging in age from 2.5 months to 5.5 years. Using nonlinear mixed effects modeling, we provide the first in vivo longitudinal description of myelin water fraction development. Moreover, we show distinct male and female developmental patterns, and demonstrate significant relationships between myelin content and measures of cognitive function. These findings advance a new understanding of healthy brain development and provide a foundation from which to assess atypical development.

No MeSH data available.