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Characterizing longitudinal white matter development during early childhood.

Dean DC, O'Muircheartaigh J, Dirks H, Waskiewicz N, Walker L, Doernberg E, Piryatinsky I, Deoni SC - Brain Struct Funct (2014)

Bottom Line: Using nonlinear mixed effects modeling, we provide the first in vivo longitudinal description of myelin water fraction development.Moreover, we show distinct male and female developmental patterns, and demonstrate significant relationships between myelin content and measures of cognitive function.These findings advance a new understanding of healthy brain development and provide a foundation from which to assess atypical development.

View Article: PubMed Central - PubMed

Affiliation: Advanced Baby Imaging Laboratory, School of Engineering, Brown University, Providence, RI, 02912, USA, douglas_dean_iii@brown.edu.

ABSTRACT
Post-mortem studies have shown the maturation of the brain's myelinated white matter, crucial for efficient and coordinated brain communication, follows a nonlinear spatio-temporal pattern that corresponds with the onset and refinement of cognitive functions and behaviors. Unfortunately, investigation of myelination in vivo is challenging and, thus, little is known about the normative pattern of myelination, or its association with functional development. Using a novel quantitative magnetic resonance imaging technique sensitive to myelin we examined longitudinal white matter development in 108 typically developing children ranging in age from 2.5 months to 5.5 years. Using nonlinear mixed effects modeling, we provide the first in vivo longitudinal description of myelin water fraction development. Moreover, we show distinct male and female developmental patterns, and demonstrate significant relationships between myelin content and measures of cognitive function. These findings advance a new understanding of healthy brain development and provide a foundation from which to assess atypical development.

No MeSH data available.


VFM developmental trajectory of the splenium of the corpus callosum. Trajectories are separated by gender, highlighting the developmental profile difference between males and females
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Fig5: VFM developmental trajectory of the splenium of the corpus callosum. Trajectories are separated by gender, highlighting the developmental profile difference between males and females

Mentions: Results from comparing the nonlinear mixed effect models fitting of gender-separated data and the male/female pairwise t tests between estimated Gompertz parameters are shown in Supplementary Table 4. F-statistics revealed no differences in the developmental trajectory residuals between the gender-separated and combined data. However, pairwise differences between male and female fixed-effect Gompertz parameter estimates were observed to be significant (Supplementary Table 4). For example, males were found to have significantly larger α values in the splenium of the corpus callosum, corresponding to an increased maximal VFM value; while differences in other model parameters (development lag, β; initial development rate, γ; and secondary development rate, δ) were found to vary between males and females in a majority of the regions investigated. On average, males were found to have a significantly larger secondary developmental rate (δ) than females, while females were found to have a larger increased maximal VFM (α) than males. Differences between these parameters are reflected in the male and female developmental trajectories, as shown in Fig. 5 for the splenium of the corpus callosum.Fig. 5


Characterizing longitudinal white matter development during early childhood.

Dean DC, O'Muircheartaigh J, Dirks H, Waskiewicz N, Walker L, Doernberg E, Piryatinsky I, Deoni SC - Brain Struct Funct (2014)

VFM developmental trajectory of the splenium of the corpus callosum. Trajectories are separated by gender, highlighting the developmental profile difference between males and females
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4481335&req=5

Fig5: VFM developmental trajectory of the splenium of the corpus callosum. Trajectories are separated by gender, highlighting the developmental profile difference between males and females
Mentions: Results from comparing the nonlinear mixed effect models fitting of gender-separated data and the male/female pairwise t tests between estimated Gompertz parameters are shown in Supplementary Table 4. F-statistics revealed no differences in the developmental trajectory residuals between the gender-separated and combined data. However, pairwise differences between male and female fixed-effect Gompertz parameter estimates were observed to be significant (Supplementary Table 4). For example, males were found to have significantly larger α values in the splenium of the corpus callosum, corresponding to an increased maximal VFM value; while differences in other model parameters (development lag, β; initial development rate, γ; and secondary development rate, δ) were found to vary between males and females in a majority of the regions investigated. On average, males were found to have a significantly larger secondary developmental rate (δ) than females, while females were found to have a larger increased maximal VFM (α) than males. Differences between these parameters are reflected in the male and female developmental trajectories, as shown in Fig. 5 for the splenium of the corpus callosum.Fig. 5

Bottom Line: Using nonlinear mixed effects modeling, we provide the first in vivo longitudinal description of myelin water fraction development.Moreover, we show distinct male and female developmental patterns, and demonstrate significant relationships between myelin content and measures of cognitive function.These findings advance a new understanding of healthy brain development and provide a foundation from which to assess atypical development.

View Article: PubMed Central - PubMed

Affiliation: Advanced Baby Imaging Laboratory, School of Engineering, Brown University, Providence, RI, 02912, USA, douglas_dean_iii@brown.edu.

ABSTRACT
Post-mortem studies have shown the maturation of the brain's myelinated white matter, crucial for efficient and coordinated brain communication, follows a nonlinear spatio-temporal pattern that corresponds with the onset and refinement of cognitive functions and behaviors. Unfortunately, investigation of myelination in vivo is challenging and, thus, little is known about the normative pattern of myelination, or its association with functional development. Using a novel quantitative magnetic resonance imaging technique sensitive to myelin we examined longitudinal white matter development in 108 typically developing children ranging in age from 2.5 months to 5.5 years. Using nonlinear mixed effects modeling, we provide the first in vivo longitudinal description of myelin water fraction development. Moreover, we show distinct male and female developmental patterns, and demonstrate significant relationships between myelin content and measures of cognitive function. These findings advance a new understanding of healthy brain development and provide a foundation from which to assess atypical development.

No MeSH data available.