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Characterizing longitudinal white matter development during early childhood.

Dean DC, O'Muircheartaigh J, Dirks H, Waskiewicz N, Walker L, Doernberg E, Piryatinsky I, Deoni SC - Brain Struct Funct (2014)

Bottom Line: Using nonlinear mixed effects modeling, we provide the first in vivo longitudinal description of myelin water fraction development.Moreover, we show distinct male and female developmental patterns, and demonstrate significant relationships between myelin content and measures of cognitive function.These findings advance a new understanding of healthy brain development and provide a foundation from which to assess atypical development.

View Article: PubMed Central - PubMed

Affiliation: Advanced Baby Imaging Laboratory, School of Engineering, Brown University, Providence, RI, 02912, USA, douglas_dean_iii@brown.edu.

ABSTRACT
Post-mortem studies have shown the maturation of the brain's myelinated white matter, crucial for efficient and coordinated brain communication, follows a nonlinear spatio-temporal pattern that corresponds with the onset and refinement of cognitive functions and behaviors. Unfortunately, investigation of myelination in vivo is challenging and, thus, little is known about the normative pattern of myelination, or its association with functional development. Using a novel quantitative magnetic resonance imaging technique sensitive to myelin we examined longitudinal white matter development in 108 typically developing children ranging in age from 2.5 months to 5.5 years. Using nonlinear mixed effects modeling, we provide the first in vivo longitudinal description of myelin water fraction development. Moreover, we show distinct male and female developmental patterns, and demonstrate significant relationships between myelin content and measures of cognitive function. These findings advance a new understanding of healthy brain development and provide a foundation from which to assess atypical development.

No MeSH data available.


Representative mean VFM developmental trajectories. Repeated measurements for each subject are connected with a straight line. Developmental trajectories are observed to follow a “S” shape pattern that is characteristic to a sigmoidal function. Anatomical locations associated with each graph: A frontal lobe white matter, B caudate, C insula, D putamen, E thalamus, F temporal lobe white matter, G parietal lobe white matter, H occipital lobe white matter, I cerebellar white matter
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Fig2: Representative mean VFM developmental trajectories. Repeated measurements for each subject are connected with a straight line. Developmental trajectories are observed to follow a “S” shape pattern that is characteristic to a sigmoidal function. Anatomical locations associated with each graph: A frontal lobe white matter, B caudate, C insula, D putamen, E thalamus, F temporal lobe white matter, G parietal lobe white matter, H occipital lobe white matter, I cerebellar white matter

Mentions: Longitudinal VFM developmental trajectories for each of the 28 investigated regions (Supplementary Fig. 2) are shown in Fig. 2. Subject-specific measurements are connected with a straight line between each repeated time point. VFM increases nonlinearly with age, following a characteristic sigmoidal pattern with more rapid changes at early ages and slower development at older ages. This temporal pattern, beginning in deep and progressing to superficial white matter in a caudal–rostral direction, qualitatively agrees with previously described histological trajectories (Flechsig 1901; Yakovlev and Lecours 1967). It is noteworthy that although regional developmental trajectories were similar in profile, distinct temporal patterns are observed for specific regions. For example, frontal white matter is observed to have a longer lag in development compared to occipital and parietal white matter regions, which is in agreement with the frontal lobes being a late developing brain region.Fig. 2


Characterizing longitudinal white matter development during early childhood.

Dean DC, O'Muircheartaigh J, Dirks H, Waskiewicz N, Walker L, Doernberg E, Piryatinsky I, Deoni SC - Brain Struct Funct (2014)

Representative mean VFM developmental trajectories. Repeated measurements for each subject are connected with a straight line. Developmental trajectories are observed to follow a “S” shape pattern that is characteristic to a sigmoidal function. Anatomical locations associated with each graph: A frontal lobe white matter, B caudate, C insula, D putamen, E thalamus, F temporal lobe white matter, G parietal lobe white matter, H occipital lobe white matter, I cerebellar white matter
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4481335&req=5

Fig2: Representative mean VFM developmental trajectories. Repeated measurements for each subject are connected with a straight line. Developmental trajectories are observed to follow a “S” shape pattern that is characteristic to a sigmoidal function. Anatomical locations associated with each graph: A frontal lobe white matter, B caudate, C insula, D putamen, E thalamus, F temporal lobe white matter, G parietal lobe white matter, H occipital lobe white matter, I cerebellar white matter
Mentions: Longitudinal VFM developmental trajectories for each of the 28 investigated regions (Supplementary Fig. 2) are shown in Fig. 2. Subject-specific measurements are connected with a straight line between each repeated time point. VFM increases nonlinearly with age, following a characteristic sigmoidal pattern with more rapid changes at early ages and slower development at older ages. This temporal pattern, beginning in deep and progressing to superficial white matter in a caudal–rostral direction, qualitatively agrees with previously described histological trajectories (Flechsig 1901; Yakovlev and Lecours 1967). It is noteworthy that although regional developmental trajectories were similar in profile, distinct temporal patterns are observed for specific regions. For example, frontal white matter is observed to have a longer lag in development compared to occipital and parietal white matter regions, which is in agreement with the frontal lobes being a late developing brain region.Fig. 2

Bottom Line: Using nonlinear mixed effects modeling, we provide the first in vivo longitudinal description of myelin water fraction development.Moreover, we show distinct male and female developmental patterns, and demonstrate significant relationships between myelin content and measures of cognitive function.These findings advance a new understanding of healthy brain development and provide a foundation from which to assess atypical development.

View Article: PubMed Central - PubMed

Affiliation: Advanced Baby Imaging Laboratory, School of Engineering, Brown University, Providence, RI, 02912, USA, douglas_dean_iii@brown.edu.

ABSTRACT
Post-mortem studies have shown the maturation of the brain's myelinated white matter, crucial for efficient and coordinated brain communication, follows a nonlinear spatio-temporal pattern that corresponds with the onset and refinement of cognitive functions and behaviors. Unfortunately, investigation of myelination in vivo is challenging and, thus, little is known about the normative pattern of myelination, or its association with functional development. Using a novel quantitative magnetic resonance imaging technique sensitive to myelin we examined longitudinal white matter development in 108 typically developing children ranging in age from 2.5 months to 5.5 years. Using nonlinear mixed effects modeling, we provide the first in vivo longitudinal description of myelin water fraction development. Moreover, we show distinct male and female developmental patterns, and demonstrate significant relationships between myelin content and measures of cognitive function. These findings advance a new understanding of healthy brain development and provide a foundation from which to assess atypical development.

No MeSH data available.