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Characterizing longitudinal white matter development during early childhood.

Dean DC, O'Muircheartaigh J, Dirks H, Waskiewicz N, Walker L, Doernberg E, Piryatinsky I, Deoni SC - Brain Struct Funct (2014)

Bottom Line: Using nonlinear mixed effects modeling, we provide the first in vivo longitudinal description of myelin water fraction development.Moreover, we show distinct male and female developmental patterns, and demonstrate significant relationships between myelin content and measures of cognitive function.These findings advance a new understanding of healthy brain development and provide a foundation from which to assess atypical development.

View Article: PubMed Central - PubMed

Affiliation: Advanced Baby Imaging Laboratory, School of Engineering, Brown University, Providence, RI, 02912, USA, douglas_dean_iii@brown.edu.

ABSTRACT
Post-mortem studies have shown the maturation of the brain's myelinated white matter, crucial for efficient and coordinated brain communication, follows a nonlinear spatio-temporal pattern that corresponds with the onset and refinement of cognitive functions and behaviors. Unfortunately, investigation of myelination in vivo is challenging and, thus, little is known about the normative pattern of myelination, or its association with functional development. Using a novel quantitative magnetic resonance imaging technique sensitive to myelin we examined longitudinal white matter development in 108 typically developing children ranging in age from 2.5 months to 5.5 years. Using nonlinear mixed effects modeling, we provide the first in vivo longitudinal description of myelin water fraction development. Moreover, we show distinct male and female developmental patterns, and demonstrate significant relationships between myelin content and measures of cognitive function. These findings advance a new understanding of healthy brain development and provide a foundation from which to assess atypical development.

No MeSH data available.


Related in: MedlinePlus

Top row: ages of the 108 subjects at each scan. Each row denotes an individual subject and the repeated measurements are connected with a dashed line. Males (blue) and females (green) are additionally distinguished. Bottom row: mean mcDESPOT VFM maps at 3, 6, 9, 12, 24, 36, 48, and 60 months of age illustrating the development of myelinated white matter throughout the brain
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Fig1: Top row: ages of the 108 subjects at each scan. Each row denotes an individual subject and the repeated measurements are connected with a dashed line. Males (blue) and females (green) are additionally distinguished. Bottom row: mean mcDESPOT VFM maps at 3, 6, 9, 12, 24, 36, 48, and 60 months of age illustrating the development of myelinated white matter throughout the brain

Mentions: A total of 260 mcDESPOT MRI datasets were acquired from the 108 participants: 73 subjects were scanned twice, 26 were scanned three times, and 9 were scanned 4 times. Matched coronal, sagittal, and coronal slices through the mean VFM maps for representative age groups are shown in Fig. 1 and illustrate the development of myelinated white matter throughout the brain.Fig. 1


Characterizing longitudinal white matter development during early childhood.

Dean DC, O'Muircheartaigh J, Dirks H, Waskiewicz N, Walker L, Doernberg E, Piryatinsky I, Deoni SC - Brain Struct Funct (2014)

Top row: ages of the 108 subjects at each scan. Each row denotes an individual subject and the repeated measurements are connected with a dashed line. Males (blue) and females (green) are additionally distinguished. Bottom row: mean mcDESPOT VFM maps at 3, 6, 9, 12, 24, 36, 48, and 60 months of age illustrating the development of myelinated white matter throughout the brain
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4481335&req=5

Fig1: Top row: ages of the 108 subjects at each scan. Each row denotes an individual subject and the repeated measurements are connected with a dashed line. Males (blue) and females (green) are additionally distinguished. Bottom row: mean mcDESPOT VFM maps at 3, 6, 9, 12, 24, 36, 48, and 60 months of age illustrating the development of myelinated white matter throughout the brain
Mentions: A total of 260 mcDESPOT MRI datasets were acquired from the 108 participants: 73 subjects were scanned twice, 26 were scanned three times, and 9 were scanned 4 times. Matched coronal, sagittal, and coronal slices through the mean VFM maps for representative age groups are shown in Fig. 1 and illustrate the development of myelinated white matter throughout the brain.Fig. 1

Bottom Line: Using nonlinear mixed effects modeling, we provide the first in vivo longitudinal description of myelin water fraction development.Moreover, we show distinct male and female developmental patterns, and demonstrate significant relationships between myelin content and measures of cognitive function.These findings advance a new understanding of healthy brain development and provide a foundation from which to assess atypical development.

View Article: PubMed Central - PubMed

Affiliation: Advanced Baby Imaging Laboratory, School of Engineering, Brown University, Providence, RI, 02912, USA, douglas_dean_iii@brown.edu.

ABSTRACT
Post-mortem studies have shown the maturation of the brain's myelinated white matter, crucial for efficient and coordinated brain communication, follows a nonlinear spatio-temporal pattern that corresponds with the onset and refinement of cognitive functions and behaviors. Unfortunately, investigation of myelination in vivo is challenging and, thus, little is known about the normative pattern of myelination, or its association with functional development. Using a novel quantitative magnetic resonance imaging technique sensitive to myelin we examined longitudinal white matter development in 108 typically developing children ranging in age from 2.5 months to 5.5 years. Using nonlinear mixed effects modeling, we provide the first in vivo longitudinal description of myelin water fraction development. Moreover, we show distinct male and female developmental patterns, and demonstrate significant relationships between myelin content and measures of cognitive function. These findings advance a new understanding of healthy brain development and provide a foundation from which to assess atypical development.

No MeSH data available.


Related in: MedlinePlus