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Dissociable Behavioral, Physiological and Neural Effects of Acute Glucose and Fructose Ingestion: A Pilot Study.

W├Âlnerhanssen BK, Meyer-Gerspach AC, Schmidt A, Zimak N, Peterli R, Beglinger C, Borgwardt S - PLoS ONE (2015)

Bottom Line: Glucose ingestion induced significantly greater elevations in plasma glucose, insulin, GLP-1 and GIP, while feelings of fullness increased and prospective food consumption decreased relative to fructose.Our findings suggest that glucose and fructose induce dissociable effects on rsFC within the basal ganglia/limbic network, which are probably mediated by different insulin levels.A larger study would be recommended in order to confirm these findings.

View Article: PubMed Central - PubMed

Affiliation: Department of Gastroenterology, University Hospital of Basel, Basel, Switzerland.

ABSTRACT
Previous research has revealed that glucose and fructose ingestion differentially modulate release of satiation hormones. Recent studies have begun to elucidate brain-gut interactions with neuroimaging approaches such as magnetic resonance imaging (MRI), but the neural mechanism underlying different behavioral and physiological effects of glucose and fructose are unclear. In this paper, we have used resting state functional MRI to explore whether acute glucose and fructose ingestion also induced dissociable effects in the neural system. Using a cross-over, double-blind, placebo-controlled design, we compared resting state functional connectivity (rsFC) strengths within the basal ganglia/limbic network in 12 healthy lean males. Each subject was administered fructose, glucose and placebo on three separate occasions. Subsequent correlation analysis was used to examine relations between rsFC findings and plasma concentrations of satiation hormones and subjective feelings of appetite. Glucose ingestion induced significantly greater elevations in plasma glucose, insulin, GLP-1 and GIP, while feelings of fullness increased and prospective food consumption decreased relative to fructose. Furthermore, glucose increased rsFC of the left caudatus and putamen, precuneus and lingual gyrus more than fructose, whereas within the basal ganglia/limbic network, fructose increased rsFC of the left amygdala, left hippocampus, right parahippocampus, orbitofrontal cortex and precentral gyrus more than glucose. Moreover, compared to fructose, the increased rsFC after glucose positively correlated with the glucose-induced increase in insulin. Our findings suggest that glucose and fructose induce dissociable effects on rsFC within the basal ganglia/limbic network, which are probably mediated by different insulin levels. A larger study would be recommended in order to confirm these findings.

No MeSH data available.


Related in: MedlinePlus

Spatial maps representing the resting state basal ganglia/limbic network for each treatment condition.Spatial maps representing the reward network detected by GICA for (A) the placebo (i.e. water), (B) glucose and (C) fructose treatment. Maps were created using a one-sample t-test for each treatment (randomize, FWE-corrected at p = 0.001). Regions belonging to this network include the entire striatum, thalamus, and amygdala. The right side of the brain is displayed on the right side of the figure.
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pone.0130280.g004: Spatial maps representing the resting state basal ganglia/limbic network for each treatment condition.Spatial maps representing the reward network detected by GICA for (A) the placebo (i.e. water), (B) glucose and (C) fructose treatment. Maps were created using a one-sample t-test for each treatment (randomize, FWE-corrected at p = 0.001). Regions belonging to this network include the entire striatum, thalamus, and amygdala. The right side of the brain is displayed on the right side of the figure.

Mentions: After glucose ingestion, dual regression of the basal ganglia/limbic network identified with GICA (Fig 4) revealed increased rsFC of the right caudatus, left pallidum and OFC to this network, relative to placebo. After placebo increased rsFC of the angular gyrus, lateral occipital cortex and precuneus was found to the basal ganglia/limbic network, relative to glucose. After fructose, increased rsFC of the OFC, cerebellum and lateral occipital cortex was found, relative to placebo. After placebo, increased rsFC of the superior parietal lobule, paracingulate gyrus and inferior frontal cortex to the basal ganglia/limbic network was found relative to fructose. Treatment comparisons relative to placebo are summarized in S1 Table.


Dissociable Behavioral, Physiological and Neural Effects of Acute Glucose and Fructose Ingestion: A Pilot Study.

W├Âlnerhanssen BK, Meyer-Gerspach AC, Schmidt A, Zimak N, Peterli R, Beglinger C, Borgwardt S - PLoS ONE (2015)

Spatial maps representing the resting state basal ganglia/limbic network for each treatment condition.Spatial maps representing the reward network detected by GICA for (A) the placebo (i.e. water), (B) glucose and (C) fructose treatment. Maps were created using a one-sample t-test for each treatment (randomize, FWE-corrected at p = 0.001). Regions belonging to this network include the entire striatum, thalamus, and amygdala. The right side of the brain is displayed on the right side of the figure.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4481317&req=5

pone.0130280.g004: Spatial maps representing the resting state basal ganglia/limbic network for each treatment condition.Spatial maps representing the reward network detected by GICA for (A) the placebo (i.e. water), (B) glucose and (C) fructose treatment. Maps were created using a one-sample t-test for each treatment (randomize, FWE-corrected at p = 0.001). Regions belonging to this network include the entire striatum, thalamus, and amygdala. The right side of the brain is displayed on the right side of the figure.
Mentions: After glucose ingestion, dual regression of the basal ganglia/limbic network identified with GICA (Fig 4) revealed increased rsFC of the right caudatus, left pallidum and OFC to this network, relative to placebo. After placebo increased rsFC of the angular gyrus, lateral occipital cortex and precuneus was found to the basal ganglia/limbic network, relative to glucose. After fructose, increased rsFC of the OFC, cerebellum and lateral occipital cortex was found, relative to placebo. After placebo, increased rsFC of the superior parietal lobule, paracingulate gyrus and inferior frontal cortex to the basal ganglia/limbic network was found relative to fructose. Treatment comparisons relative to placebo are summarized in S1 Table.

Bottom Line: Glucose ingestion induced significantly greater elevations in plasma glucose, insulin, GLP-1 and GIP, while feelings of fullness increased and prospective food consumption decreased relative to fructose.Our findings suggest that glucose and fructose induce dissociable effects on rsFC within the basal ganglia/limbic network, which are probably mediated by different insulin levels.A larger study would be recommended in order to confirm these findings.

View Article: PubMed Central - PubMed

Affiliation: Department of Gastroenterology, University Hospital of Basel, Basel, Switzerland.

ABSTRACT
Previous research has revealed that glucose and fructose ingestion differentially modulate release of satiation hormones. Recent studies have begun to elucidate brain-gut interactions with neuroimaging approaches such as magnetic resonance imaging (MRI), but the neural mechanism underlying different behavioral and physiological effects of glucose and fructose are unclear. In this paper, we have used resting state functional MRI to explore whether acute glucose and fructose ingestion also induced dissociable effects in the neural system. Using a cross-over, double-blind, placebo-controlled design, we compared resting state functional connectivity (rsFC) strengths within the basal ganglia/limbic network in 12 healthy lean males. Each subject was administered fructose, glucose and placebo on three separate occasions. Subsequent correlation analysis was used to examine relations between rsFC findings and plasma concentrations of satiation hormones and subjective feelings of appetite. Glucose ingestion induced significantly greater elevations in plasma glucose, insulin, GLP-1 and GIP, while feelings of fullness increased and prospective food consumption decreased relative to fructose. Furthermore, glucose increased rsFC of the left caudatus and putamen, precuneus and lingual gyrus more than fructose, whereas within the basal ganglia/limbic network, fructose increased rsFC of the left amygdala, left hippocampus, right parahippocampus, orbitofrontal cortex and precentral gyrus more than glucose. Moreover, compared to fructose, the increased rsFC after glucose positively correlated with the glucose-induced increase in insulin. Our findings suggest that glucose and fructose induce dissociable effects on rsFC within the basal ganglia/limbic network, which are probably mediated by different insulin levels. A larger study would be recommended in order to confirm these findings.

No MeSH data available.


Related in: MedlinePlus