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Prognostic and clinical significance of claudin-4 in gastric cancer: a meta-analysis.

Liu JX, Wei ZY, Chen JS, Lu HC, Hao L, Li WJ - World J Surg Oncol (2015)

Bottom Line: Systematic searches on PubMed, Embase, and Cochrane Library prior to December 2014 were performed.Over-expression of claudin-4 was also associated with advanced stage (OR: 1.96, 95 % CI: 1.08-3.56) and lymphoid node metastasis (OR: 1.72, 95 % CI: 1.05-2.81) of gastric cancer patients.No significant publication bias was found among the studies (P > 0.05).

View Article: PubMed Central - PubMed

Affiliation: Department of General Surgery, No. 1 People's Hospital of Nanning, 89 Qixing Rd, Nanning, 530022, China.

ABSTRACT

Background: The current reports on the association of claudin-4 expression with gastric cancer outcome were inconsistent. Thus, we conducted a meta-analysis to assess the association of claudin-4 expression with the prognosis and clinical parameters more precisely.

Methods: Systematic searches on PubMed, Embase, and Cochrane Library prior to December 2014 were performed. The pooled hazard ratio (HR) with its 95 % confidence interval (95 %CI) was used to assess the prognostic value of claudin-4 expression with gastric cancer patients, and the pooled odds ratio (OR) with its 95 %CI was used to assess the association with clinical parameters.

Results: Nine studies with a total of 1265 gastric cancer patients were included. Overall, the pooled results showed that over-expression of claudin-4 was associated with a poor survival in gastric cancer patients (HR: 2.01, 95 % CI: 1.62-2.50). Over-expression of claudin-4 was also associated with advanced stage (OR: 1.96, 95 % CI: 1.08-3.56) and lymphoid node metastasis (OR: 1.72, 95 % CI: 1.05-2.81) of gastric cancer patients. No significant publication bias was found among the studies (P > 0.05).

Conclusions: This meta-analysis shows that over-expression of claudin-4 is associated with progress of gastric cancer and poor prognosis of gastric cancer patients.

No MeSH data available.


Related in: MedlinePlus

Meta-analysis of claudin-4 expression with lymphoid node metastasis of gastric cancer
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Fig4: Meta-analysis of claudin-4 expression with lymphoid node metastasis of gastric cancer

Mentions: We found that over-expression of claudin-4 was associated with lymphoid node metastasis after we pooled the data of eight studies with 1119 patients (OR: 1.72, 95 % CI: 1.05–2.81, P = 0.026), but there was moderate heterogeneity across the studies (I2 = 47.0, P = 0.067). See Fig. 4. The sensitivity analysis was similar to the main result after removing each study in turn. Publication bias was negligible across the studies (Egger’s test: P = 0.473; Begg’s test: P = 0.911).Fig. 4


Prognostic and clinical significance of claudin-4 in gastric cancer: a meta-analysis.

Liu JX, Wei ZY, Chen JS, Lu HC, Hao L, Li WJ - World J Surg Oncol (2015)

Meta-analysis of claudin-4 expression with lymphoid node metastasis of gastric cancer
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4481068&req=5

Fig4: Meta-analysis of claudin-4 expression with lymphoid node metastasis of gastric cancer
Mentions: We found that over-expression of claudin-4 was associated with lymphoid node metastasis after we pooled the data of eight studies with 1119 patients (OR: 1.72, 95 % CI: 1.05–2.81, P = 0.026), but there was moderate heterogeneity across the studies (I2 = 47.0, P = 0.067). See Fig. 4. The sensitivity analysis was similar to the main result after removing each study in turn. Publication bias was negligible across the studies (Egger’s test: P = 0.473; Begg’s test: P = 0.911).Fig. 4

Bottom Line: Systematic searches on PubMed, Embase, and Cochrane Library prior to December 2014 were performed.Over-expression of claudin-4 was also associated with advanced stage (OR: 1.96, 95 % CI: 1.08-3.56) and lymphoid node metastasis (OR: 1.72, 95 % CI: 1.05-2.81) of gastric cancer patients.No significant publication bias was found among the studies (P > 0.05).

View Article: PubMed Central - PubMed

Affiliation: Department of General Surgery, No. 1 People's Hospital of Nanning, 89 Qixing Rd, Nanning, 530022, China.

ABSTRACT

Background: The current reports on the association of claudin-4 expression with gastric cancer outcome were inconsistent. Thus, we conducted a meta-analysis to assess the association of claudin-4 expression with the prognosis and clinical parameters more precisely.

Methods: Systematic searches on PubMed, Embase, and Cochrane Library prior to December 2014 were performed. The pooled hazard ratio (HR) with its 95 % confidence interval (95 %CI) was used to assess the prognostic value of claudin-4 expression with gastric cancer patients, and the pooled odds ratio (OR) with its 95 %CI was used to assess the association with clinical parameters.

Results: Nine studies with a total of 1265 gastric cancer patients were included. Overall, the pooled results showed that over-expression of claudin-4 was associated with a poor survival in gastric cancer patients (HR: 2.01, 95 % CI: 1.62-2.50). Over-expression of claudin-4 was also associated with advanced stage (OR: 1.96, 95 % CI: 1.08-3.56) and lymphoid node metastasis (OR: 1.72, 95 % CI: 1.05-2.81) of gastric cancer patients. No significant publication bias was found among the studies (P > 0.05).

Conclusions: This meta-analysis shows that over-expression of claudin-4 is associated with progress of gastric cancer and poor prognosis of gastric cancer patients.

No MeSH data available.


Related in: MedlinePlus