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Heterogeneous living donor hepatic fat distribution on MRI chemical shift imaging.

Choi Y, Lee JM, Yi NJ, Kim H, Park MS, Hong G, Yoo T, Suh SW, Lee HW, Lee KW, Suh KS - Ann Surg Treat Res (2015)

Bottom Line: Fat deposit amount in S1, S2, S3 and deep regions of S4-S8 were significantly different from one another (F [4.003, 58.032] = 8.684, P < 0.001), while there were no differences among the peripheral regions of S4-S8 (F [2.9, 5.3] = 1.3, P = 0.272) by repeated measure analysis of variance method.And regional differences of the amount of fat deposit in the whole liver increased as a peripheral fat fraction of S5 increased (R(2) = 0.428, P < 0.001).Multifocal fat measurements for the whole liver are needed because a small regional evaluation might not represent the remaining liver completely, especially in patients with severe hepatic steatosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Seoul National University Bundang Hospital, Seongnam, Korea.

ABSTRACT

Purpose: We evaluated the heterogeneity of steatosis in living donor livers to determine its regional differences.

Methods: Between June 2011 and February 2012, 81 liver donors were selected. Fat fraction was estimated using magnetic resonance triple-echo chemical shifting gradient imaging in 13 different regions: segment 1 (S1), S2, S3, and each peripheral and deep region of S4, S5, S6, S7, and S8.

Results: There were differences (range, 3.2%-5.3%) in fat fractions between each peripheral and deep region of S4, S6, S7, and S8 (P < 0.001, P = 0.004, P < 0.001, and P = 0.006). Fat deposit amount in S1, S2, S3 and deep regions of S4-S8 were significantly different from one another (F [4.003, 58.032] = 8.684, P < 0.001), while there were no differences among the peripheral regions of S4-S8 (F [2.9, 5.3] = 1.3, P = 0.272) by repeated measure analysis of variance method. And regional differences of the amount of fat deposit in the whole liver increased as a peripheral fat fraction of S5 increased (R(2) = 0.428, P < 0.001).

Conclusion: Multifocal fat measurements for the whole liver are needed because a small regional evaluation might not represent the remaining liver completely, especially in patients with severe hepatic steatosis.

No MeSH data available.


Related in: MedlinePlus

Estimating the fat fraction in peripheral region and deep region. The fat fraction (1/10 of the mean value in the region of interest) in the peripheral region measures 17.5% and in the deep region measures 21.7%. SD, standard deviation.
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Figure 1: Estimating the fat fraction in peripheral region and deep region. The fat fraction (1/10 of the mean value in the region of interest) in the peripheral region measures 17.5% and in the deep region measures 21.7%. SD, standard deviation.

Mentions: The fat fraction was estimated in 13 different areas: (S1, S2, S3, the peripheral and deep regions of S4, S5, S6, S7, S8). The peripheral and deep regions were arbitrary demarcated at a level 2/3 the distance from the caudate lobe to the liver surface. To estimate fat fraction in the peripheral regions and deep regions of the liver, an ROI of approximately 1-2 cm2 was drawn in each region. ROIs in the peripheral region of S4, S5, S6, S7, S8 were long, narrow freehand ROIs drawn along the liver surface. Circular ROIs, avoiding hepatic and portal veins, were used in the deep regions of the same segments (Fig. 1). However, because of their size, S1, S2, and S3 could not be divided into peripheral and deep regions. The fat fraction in each area was the average of three fat fractions measurements taken on 3 different consecutive axial images.


Heterogeneous living donor hepatic fat distribution on MRI chemical shift imaging.

Choi Y, Lee JM, Yi NJ, Kim H, Park MS, Hong G, Yoo T, Suh SW, Lee HW, Lee KW, Suh KS - Ann Surg Treat Res (2015)

Estimating the fat fraction in peripheral region and deep region. The fat fraction (1/10 of the mean value in the region of interest) in the peripheral region measures 17.5% and in the deep region measures 21.7%. SD, standard deviation.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4481030&req=5

Figure 1: Estimating the fat fraction in peripheral region and deep region. The fat fraction (1/10 of the mean value in the region of interest) in the peripheral region measures 17.5% and in the deep region measures 21.7%. SD, standard deviation.
Mentions: The fat fraction was estimated in 13 different areas: (S1, S2, S3, the peripheral and deep regions of S4, S5, S6, S7, S8). The peripheral and deep regions were arbitrary demarcated at a level 2/3 the distance from the caudate lobe to the liver surface. To estimate fat fraction in the peripheral regions and deep regions of the liver, an ROI of approximately 1-2 cm2 was drawn in each region. ROIs in the peripheral region of S4, S5, S6, S7, S8 were long, narrow freehand ROIs drawn along the liver surface. Circular ROIs, avoiding hepatic and portal veins, were used in the deep regions of the same segments (Fig. 1). However, because of their size, S1, S2, and S3 could not be divided into peripheral and deep regions. The fat fraction in each area was the average of three fat fractions measurements taken on 3 different consecutive axial images.

Bottom Line: Fat deposit amount in S1, S2, S3 and deep regions of S4-S8 were significantly different from one another (F [4.003, 58.032] = 8.684, P < 0.001), while there were no differences among the peripheral regions of S4-S8 (F [2.9, 5.3] = 1.3, P = 0.272) by repeated measure analysis of variance method.And regional differences of the amount of fat deposit in the whole liver increased as a peripheral fat fraction of S5 increased (R(2) = 0.428, P < 0.001).Multifocal fat measurements for the whole liver are needed because a small regional evaluation might not represent the remaining liver completely, especially in patients with severe hepatic steatosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Seoul National University Bundang Hospital, Seongnam, Korea.

ABSTRACT

Purpose: We evaluated the heterogeneity of steatosis in living donor livers to determine its regional differences.

Methods: Between June 2011 and February 2012, 81 liver donors were selected. Fat fraction was estimated using magnetic resonance triple-echo chemical shifting gradient imaging in 13 different regions: segment 1 (S1), S2, S3, and each peripheral and deep region of S4, S5, S6, S7, and S8.

Results: There were differences (range, 3.2%-5.3%) in fat fractions between each peripheral and deep region of S4, S6, S7, and S8 (P < 0.001, P = 0.004, P < 0.001, and P = 0.006). Fat deposit amount in S1, S2, S3 and deep regions of S4-S8 were significantly different from one another (F [4.003, 58.032] = 8.684, P < 0.001), while there were no differences among the peripheral regions of S4-S8 (F [2.9, 5.3] = 1.3, P = 0.272) by repeated measure analysis of variance method. And regional differences of the amount of fat deposit in the whole liver increased as a peripheral fat fraction of S5 increased (R(2) = 0.428, P < 0.001).

Conclusion: Multifocal fat measurements for the whole liver are needed because a small regional evaluation might not represent the remaining liver completely, especially in patients with severe hepatic steatosis.

No MeSH data available.


Related in: MedlinePlus