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Preterm born 9-year-olds have elevated IGF-1 and low prolactin, but levels vary with behavioural and eating disorders.

Kistner A, Deschmann E, Legnevall L, Vanpee M - Acta Paediatr. (2014)

Bottom Line: Preterm children had lower prolactin (p = 0.01) and higher IGF-I than controls (p < 0.05, adjusted for confounders), despite being significantly shorter than the predicted target height (p < 0.001).These disorders were associated with lower leptin (p < 0.01), insulin (p < 0.05) and IGF-I (p < 0.05), but correlations between these hormones and leptin were similar among the groups.This raises speculation about IGF-I receptor insensitivity.

View Article: PubMed Central - PubMed

Affiliation: Department of Molecular Medicine and Surgery, Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Stockholm, Sweden.

No MeSH data available.


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A schematic of our hypothesis based on our findings.
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fig02: A schematic of our hypothesis based on our findings.

Mentions: We found lower levels of leptin, insulin and IGF-I in preterm children with behavioural and/or eating disorders compared with preterm children without those disorders. However, the associations between hormones and leptin were similar between these groups. This indicated that several hormones were associated with leptin (i.e. the percentage of fat tissue) in a similar way in the two groups. Therefore, the regulation of these hormones in relation to leptin appeared to be functioning properly in subjects with behavioural and/or eating disorders. As a consequence, the cause of lower hormone levels in these subjects is unknown. One may speculate that the preterm birth alters a neuronal set point, which induces lower levels of IGF-I, insulin and leptin in this group compared with children born preterm without disorders. Conversely, behavioural/eating disorders may also result in these findings (29). Unfortunately, we lack information about the thyroid function/status in this cohort. Based on our findings, we propose a hypothesis that integrates our findings (Fig.2).


Preterm born 9-year-olds have elevated IGF-1 and low prolactin, but levels vary with behavioural and eating disorders.

Kistner A, Deschmann E, Legnevall L, Vanpee M - Acta Paediatr. (2014)

A schematic of our hypothesis based on our findings.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4480651&req=5

fig02: A schematic of our hypothesis based on our findings.
Mentions: We found lower levels of leptin, insulin and IGF-I in preterm children with behavioural and/or eating disorders compared with preterm children without those disorders. However, the associations between hormones and leptin were similar between these groups. This indicated that several hormones were associated with leptin (i.e. the percentage of fat tissue) in a similar way in the two groups. Therefore, the regulation of these hormones in relation to leptin appeared to be functioning properly in subjects with behavioural and/or eating disorders. As a consequence, the cause of lower hormone levels in these subjects is unknown. One may speculate that the preterm birth alters a neuronal set point, which induces lower levels of IGF-I, insulin and leptin in this group compared with children born preterm without disorders. Conversely, behavioural/eating disorders may also result in these findings (29). Unfortunately, we lack information about the thyroid function/status in this cohort. Based on our findings, we propose a hypothesis that integrates our findings (Fig.2).

Bottom Line: Preterm children had lower prolactin (p = 0.01) and higher IGF-I than controls (p < 0.05, adjusted for confounders), despite being significantly shorter than the predicted target height (p < 0.001).These disorders were associated with lower leptin (p < 0.01), insulin (p < 0.05) and IGF-I (p < 0.05), but correlations between these hormones and leptin were similar among the groups.This raises speculation about IGF-I receptor insensitivity.

View Article: PubMed Central - PubMed

Affiliation: Department of Molecular Medicine and Surgery, Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Stockholm, Sweden.

No MeSH data available.


Related in: MedlinePlus