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Neuropharmacological effect of methylphenidate on attention network in children with attention deficit hyperactivity disorder during oddball paradigms as assessed using functional near-infrared spectroscopy.

Nagashima M, Monden Y, Dan I, Dan H, Tsuzuki D, Mizutani T, Kyutoku Y, Gunji Y, Momoi MY, Watanabe E, Yamagata T - Neurophotonics (2014)

Bottom Line: The reduced right prefrontal activation was normalized after methylphenidate but not placebo administration in ADHD children.These results are consistent with the neuropharmacological effects of methylphenidate to upregulate the dopamine system in the prefrontal cortex innervating from the ventral tegmentum (mesocortical pathway), but not the noradrenergic system from the parietal cortex to the locus coeruleus.Thus, right prefrontal activation would serve as an objective neurofunctional biomarker to indicate the effectiveness of methylphenidate on ADHD children in attentional control. fNIRS monitoring enhances early clinical diagnosis and the treatment of ADHD children, especially those with an inattention phenotype.

View Article: PubMed Central - PubMed

Affiliation: Jichi Medical University , Department of Pediatrics, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan.

ABSTRACT
The current study aimed to explore the neural substrate for methylphenidate effects on attentional control in school-aged children with attention deficit hyperactivity disorder (ADHD) using functional near-infrared spectroscopy (fNIRS), which can be applied to young children with ADHD more easily than conventional neuroimaging modalities. Using fNIRS, we monitored the oxy-hemoglobin signal changes of 22 ADHD children (6 to 14 years old) performing an oddball task before and 1.5 h after methylphenidate or placebo administration, in a randomized, double-blind, placebo-controlled, crossover design. Twenty-two age- and gender-matched normal controls without methylphenidate administration were also monitored. In the control subjects, the oddball task recruited the right prefrontal and inferior parietal cortices, and this activation was absent in premedicated ADHD children. The reduced right prefrontal activation was normalized after methylphenidate but not placebo administration in ADHD children. These results are consistent with the neuropharmacological effects of methylphenidate to upregulate the dopamine system in the prefrontal cortex innervating from the ventral tegmentum (mesocortical pathway), but not the noradrenergic system from the parietal cortex to the locus coeruleus. Thus, right prefrontal activation would serve as an objective neurofunctional biomarker to indicate the effectiveness of methylphenidate on ADHD children in attentional control. fNIRS monitoring enhances early clinical diagnosis and the treatment of ADHD children, especially those with an inattention phenotype.

No MeSH data available.


Related in: MedlinePlus

Experimental design. A schematic showing the flow of pre- and postmedication administration sessions for attention deficit hyperactivity disorder (ADHD) subjects. Functional near-infrared spectroscopy (fNIRS) measurements. Brain activity was measured while ADHD and control subjects performed the oddball task.
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f1: Experimental design. A schematic showing the flow of pre- and postmedication administration sessions for attention deficit hyperactivity disorder (ADHD) subjects. Functional near-infrared spectroscopy (fNIRS) measurements. Brain activity was measured while ADHD and control subjects performed the oddball task.

Mentions: A visual-based oddball task was adopted to represent measures of attention. The task includes detection and response to infrequent (oddball) target events included in a series of repetitive events. This type of task has also been referred to as a response selection task.35 The effects of MPH while the subjects performed oddball tasks were examined in a randomized, double-blind, placebo-controlled, crossover study. Experimental procedure is summarized in Fig. 1.


Neuropharmacological effect of methylphenidate on attention network in children with attention deficit hyperactivity disorder during oddball paradigms as assessed using functional near-infrared spectroscopy.

Nagashima M, Monden Y, Dan I, Dan H, Tsuzuki D, Mizutani T, Kyutoku Y, Gunji Y, Momoi MY, Watanabe E, Yamagata T - Neurophotonics (2014)

Experimental design. A schematic showing the flow of pre- and postmedication administration sessions for attention deficit hyperactivity disorder (ADHD) subjects. Functional near-infrared spectroscopy (fNIRS) measurements. Brain activity was measured while ADHD and control subjects performed the oddball task.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4478959&req=5

f1: Experimental design. A schematic showing the flow of pre- and postmedication administration sessions for attention deficit hyperactivity disorder (ADHD) subjects. Functional near-infrared spectroscopy (fNIRS) measurements. Brain activity was measured while ADHD and control subjects performed the oddball task.
Mentions: A visual-based oddball task was adopted to represent measures of attention. The task includes detection and response to infrequent (oddball) target events included in a series of repetitive events. This type of task has also been referred to as a response selection task.35 The effects of MPH while the subjects performed oddball tasks were examined in a randomized, double-blind, placebo-controlled, crossover study. Experimental procedure is summarized in Fig. 1.

Bottom Line: The reduced right prefrontal activation was normalized after methylphenidate but not placebo administration in ADHD children.These results are consistent with the neuropharmacological effects of methylphenidate to upregulate the dopamine system in the prefrontal cortex innervating from the ventral tegmentum (mesocortical pathway), but not the noradrenergic system from the parietal cortex to the locus coeruleus.Thus, right prefrontal activation would serve as an objective neurofunctional biomarker to indicate the effectiveness of methylphenidate on ADHD children in attentional control. fNIRS monitoring enhances early clinical diagnosis and the treatment of ADHD children, especially those with an inattention phenotype.

View Article: PubMed Central - PubMed

Affiliation: Jichi Medical University , Department of Pediatrics, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan.

ABSTRACT
The current study aimed to explore the neural substrate for methylphenidate effects on attentional control in school-aged children with attention deficit hyperactivity disorder (ADHD) using functional near-infrared spectroscopy (fNIRS), which can be applied to young children with ADHD more easily than conventional neuroimaging modalities. Using fNIRS, we monitored the oxy-hemoglobin signal changes of 22 ADHD children (6 to 14 years old) performing an oddball task before and 1.5 h after methylphenidate or placebo administration, in a randomized, double-blind, placebo-controlled, crossover design. Twenty-two age- and gender-matched normal controls without methylphenidate administration were also monitored. In the control subjects, the oddball task recruited the right prefrontal and inferior parietal cortices, and this activation was absent in premedicated ADHD children. The reduced right prefrontal activation was normalized after methylphenidate but not placebo administration in ADHD children. These results are consistent with the neuropharmacological effects of methylphenidate to upregulate the dopamine system in the prefrontal cortex innervating from the ventral tegmentum (mesocortical pathway), but not the noradrenergic system from the parietal cortex to the locus coeruleus. Thus, right prefrontal activation would serve as an objective neurofunctional biomarker to indicate the effectiveness of methylphenidate on ADHD children in attentional control. fNIRS monitoring enhances early clinical diagnosis and the treatment of ADHD children, especially those with an inattention phenotype.

No MeSH data available.


Related in: MedlinePlus