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Neuropharmacological effect of atomoxetine on attention network in children with attention deficit hyperactivity disorder during oddball paradigms as assessed using functional near-infrared spectroscopy.

Nagashima M, Monden Y, Dan I, Dan H, Mizutani T, Tsuzuki D, Kyutoku Y, Gunji Y, Hirano D, Taniguchi T, Shimoizumi H, Momoi MY, Yamagata T, Watanabe E - Neurophotonics (2014)

Bottom Line: Fifteen age-, gender-, and intelligence quotient-matched normal controls without atomoxetine administration were also monitored.In the control subjects, the oddball task recruited the right prefrontal and inferior parietal cortices.This was in contrast to our previous study using a similar protocol showing methylphenidate-induced normalization of only the right prefrontal function. fNIRS allows the detection of differential neuropharmacological profiles of both substances in the attentional network: the neuropharmacological effects of atomoxetine to upregulate the noradrenergic system reflected in the right prefrontal and inferior parietal activations and those of methylphenidate to upregulate the dopamine system reflected in the prefrontal cortex activation.

View Article: PubMed Central - PubMed

Affiliation: Jichi Medical University , Department of Pediatrics, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan.

ABSTRACT
The current study aimed to explore the neural substrate for atomoxetine effects on attentional control in school-aged children with attention deficit hyperactivity disorder (ADHD) using functional near-infrared spectroscopy (fNIRS), which can be applied to young children with ADHD more easily than conventional neuroimaging modalities. Using fNIRS, we monitored the oxy-hemoglobin signal changes of 15 ADHD children (6 to 14 years old) performing an oddball task before and 1.5 h after atomoxetine or placebo administration, in a randomized, double-blind, placebo-controlled, crossover design. Fifteen age-, gender-, and intelligence quotient-matched normal controls without atomoxetine administration were also monitored. In the control subjects, the oddball task recruited the right prefrontal and inferior parietal cortices. The right prefrontal and parietal activation was normalized after atomoxetine administration in ADHD children. This was in contrast to our previous study using a similar protocol showing methylphenidate-induced normalization of only the right prefrontal function. fNIRS allows the detection of differential neuropharmacological profiles of both substances in the attentional network: the neuropharmacological effects of atomoxetine to upregulate the noradrenergic system reflected in the right prefrontal and inferior parietal activations and those of methylphenidate to upregulate the dopamine system reflected in the prefrontal cortex activation.

No MeSH data available.


Related in: MedlinePlus

Experimental design.
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f1: Experimental design.

Mentions: We adopted a visual-based oddball task that represents measures of attention. The task consists of detection of and response to infrequent (oddball) target events included in a series of repetitive events. An oddball task is often referred to as a response selection task. The effects of ATX while the subjects performed oddball tasks were examined in a randomized, double-blind, placebo-controlled, crossover study. We summarize the experimental procedure in Fig. 1.


Neuropharmacological effect of atomoxetine on attention network in children with attention deficit hyperactivity disorder during oddball paradigms as assessed using functional near-infrared spectroscopy.

Nagashima M, Monden Y, Dan I, Dan H, Mizutani T, Tsuzuki D, Kyutoku Y, Gunji Y, Hirano D, Taniguchi T, Shimoizumi H, Momoi MY, Yamagata T, Watanabe E - Neurophotonics (2014)

Experimental design.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4478726&req=5

f1: Experimental design.
Mentions: We adopted a visual-based oddball task that represents measures of attention. The task consists of detection of and response to infrequent (oddball) target events included in a series of repetitive events. An oddball task is often referred to as a response selection task. The effects of ATX while the subjects performed oddball tasks were examined in a randomized, double-blind, placebo-controlled, crossover study. We summarize the experimental procedure in Fig. 1.

Bottom Line: Fifteen age-, gender-, and intelligence quotient-matched normal controls without atomoxetine administration were also monitored.In the control subjects, the oddball task recruited the right prefrontal and inferior parietal cortices.This was in contrast to our previous study using a similar protocol showing methylphenidate-induced normalization of only the right prefrontal function. fNIRS allows the detection of differential neuropharmacological profiles of both substances in the attentional network: the neuropharmacological effects of atomoxetine to upregulate the noradrenergic system reflected in the right prefrontal and inferior parietal activations and those of methylphenidate to upregulate the dopamine system reflected in the prefrontal cortex activation.

View Article: PubMed Central - PubMed

Affiliation: Jichi Medical University , Department of Pediatrics, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan.

ABSTRACT
The current study aimed to explore the neural substrate for atomoxetine effects on attentional control in school-aged children with attention deficit hyperactivity disorder (ADHD) using functional near-infrared spectroscopy (fNIRS), which can be applied to young children with ADHD more easily than conventional neuroimaging modalities. Using fNIRS, we monitored the oxy-hemoglobin signal changes of 15 ADHD children (6 to 14 years old) performing an oddball task before and 1.5 h after atomoxetine or placebo administration, in a randomized, double-blind, placebo-controlled, crossover design. Fifteen age-, gender-, and intelligence quotient-matched normal controls without atomoxetine administration were also monitored. In the control subjects, the oddball task recruited the right prefrontal and inferior parietal cortices. The right prefrontal and parietal activation was normalized after atomoxetine administration in ADHD children. This was in contrast to our previous study using a similar protocol showing methylphenidate-induced normalization of only the right prefrontal function. fNIRS allows the detection of differential neuropharmacological profiles of both substances in the attentional network: the neuropharmacological effects of atomoxetine to upregulate the noradrenergic system reflected in the right prefrontal and inferior parietal activations and those of methylphenidate to upregulate the dopamine system reflected in the prefrontal cortex activation.

No MeSH data available.


Related in: MedlinePlus