Limits...
Improved Detection and Characterization of Copy Number Variations Among Diverse Pig Breeds by Array CGH.

Wang J, Jiang J, Wang H, Kang H, Zhang Q, Liu JF - G3 (Bethesda) (2015)

Bottom Line: Of the total porcine genes, 1295 genes were completely or partially overlapped with the identified CNVRs, which enriched in the terms related to sensory perception of the environment, neurodevelopmental processes, response to external stimuli, and immunity.Further probing the potential functions of these genes, we also found a suite of genes related important traits, which make them a promising resource for exploring the genetic basis of phenotype differences among diverse pig breeds.CNVs detected in diverse populations herein are essentially complementary to the CNV map in the pig genome, which would be helpful for understanding the pig genome variants and investigating the associations between various phenotypes and CNVs.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Animal Genetics, Breeding, and Reproduction, Ministry of Agriculture, National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China Shandong Provincial Key Laboratory of Animal Disease Control and Breeding, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan 250100, China.

No MeSH data available.


Related in: MedlinePlus

Dendrogram generated by clustering of all the individuals tested on the basis of their CNVR similarities. Numbers at the upper left and upper right of the node and beneath the nodes indicate P value, bp values, and edge numbers, respectively.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4478553&req=5

fig4: Dendrogram generated by clustering of all the individuals tested on the basis of their CNVR similarities. Numbers at the upper left and upper right of the node and beneath the nodes indicate P value, bp values, and edge numbers, respectively.

Mentions: We also performed the clustering analysis based on the status of CNVRs carried by each test individual. The resulting dendrogram, together with the bootstrap values of every branch (most of them ≥50), is given in Figure 4. The two pigs of European breeds and all other Chinese-originated pigs were clearly divided into two distinct clusters. Within the cluster of Chinese pigs, the genetic relationships of nine individuals tested were basically consistent with that geographical distribution, and two of the three pairs of samples of the same breeds (MS7 and MS8, Z2 and Z5) grouped together. This cluster analysis implies that CNVs may provide information as useful markers in the cluster analysis.


Improved Detection and Characterization of Copy Number Variations Among Diverse Pig Breeds by Array CGH.

Wang J, Jiang J, Wang H, Kang H, Zhang Q, Liu JF - G3 (Bethesda) (2015)

Dendrogram generated by clustering of all the individuals tested on the basis of their CNVR similarities. Numbers at the upper left and upper right of the node and beneath the nodes indicate P value, bp values, and edge numbers, respectively.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4478553&req=5

fig4: Dendrogram generated by clustering of all the individuals tested on the basis of their CNVR similarities. Numbers at the upper left and upper right of the node and beneath the nodes indicate P value, bp values, and edge numbers, respectively.
Mentions: We also performed the clustering analysis based on the status of CNVRs carried by each test individual. The resulting dendrogram, together with the bootstrap values of every branch (most of them ≥50), is given in Figure 4. The two pigs of European breeds and all other Chinese-originated pigs were clearly divided into two distinct clusters. Within the cluster of Chinese pigs, the genetic relationships of nine individuals tested were basically consistent with that geographical distribution, and two of the three pairs of samples of the same breeds (MS7 and MS8, Z2 and Z5) grouped together. This cluster analysis implies that CNVs may provide information as useful markers in the cluster analysis.

Bottom Line: Of the total porcine genes, 1295 genes were completely or partially overlapped with the identified CNVRs, which enriched in the terms related to sensory perception of the environment, neurodevelopmental processes, response to external stimuli, and immunity.Further probing the potential functions of these genes, we also found a suite of genes related important traits, which make them a promising resource for exploring the genetic basis of phenotype differences among diverse pig breeds.CNVs detected in diverse populations herein are essentially complementary to the CNV map in the pig genome, which would be helpful for understanding the pig genome variants and investigating the associations between various phenotypes and CNVs.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Animal Genetics, Breeding, and Reproduction, Ministry of Agriculture, National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China Shandong Provincial Key Laboratory of Animal Disease Control and Breeding, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan 250100, China.

No MeSH data available.


Related in: MedlinePlus