Limits...
Sarcomatous Carcinoma of the Orbit: A Case Report and Review of the Literature.

Mathew N, Mathew M, Farrah J - Case Rep Ophthalmol (2015)

Bottom Line: SC is associated with a poor prognosis and advanced disease at presentation.Treatment options are generally aggressive but risky, and frequently yield poor results.Due to the rarity of SC, there has been little focus on the development of improved treatment options.

View Article: PubMed Central - PubMed

Affiliation: Oral and Maxillofacial Surgery, Queensland Health, The University of Queensland, Herston, Qld., Australia.

ABSTRACT
Sarcomatous carcinomas (SCs) are rare tumours that contain malignant cells with epithelial and mesenchymal characteristics. SC rarely presents in the head and neck, and occurs even less often in the orbit. Only 8 cases of SCs located in the orbit or affecting the globe function have been described in the English literature. Here, we report a case of SC affecting the right orbit. SC is associated with a poor prognosis and advanced disease at presentation. Diagnosis is difficult, as histology often fails to definitively identify SC, necessitating a wide panel of molecular/immunological markers. Treatment options are generally aggressive but risky, and frequently yield poor results. Due to the rarity of SC, there has been little focus on the development of improved treatment options.

No MeSH data available.


Related in: MedlinePlus

a Immunohistochemistry: vimentin-positive staining of resection specimen at ×200 magnification. b 34BE12-positive staining of resection specimen at ×100 magnification. c AE1/AE3-positive staining of resection specimen at ×100 magnification.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4478310&req=5

Figure 3: a Immunohistochemistry: vimentin-positive staining of resection specimen at ×200 magnification. b 34BE12-positive staining of resection specimen at ×100 magnification. c AE1/AE3-positive staining of resection specimen at ×100 magnification.

Mentions: Biopsy fragments demonstrated malignant spindle cells with pleomorphic nuclei, eosinophilic cytoplasm, and some cohesive areas with epithelioid tumour cells; other areas revealed tumour cells with bright eosinophilic cytoplasm, suggesting a squamous differentiation. Furthermore, immunohistochemistry (IHC) analyses for smooth muscle actin and muscle-specific actin were moderately positive (consistent with sarcomatoid differentiation). IHC analyses also were positive for AE1/AE3, high-molecular-weight keratin (HMWK) 34BE12, and vimentin (fig. 3), supporting the diagnosis of SC.


Sarcomatous Carcinoma of the Orbit: A Case Report and Review of the Literature.

Mathew N, Mathew M, Farrah J - Case Rep Ophthalmol (2015)

a Immunohistochemistry: vimentin-positive staining of resection specimen at ×200 magnification. b 34BE12-positive staining of resection specimen at ×100 magnification. c AE1/AE3-positive staining of resection specimen at ×100 magnification.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4478310&req=5

Figure 3: a Immunohistochemistry: vimentin-positive staining of resection specimen at ×200 magnification. b 34BE12-positive staining of resection specimen at ×100 magnification. c AE1/AE3-positive staining of resection specimen at ×100 magnification.
Mentions: Biopsy fragments demonstrated malignant spindle cells with pleomorphic nuclei, eosinophilic cytoplasm, and some cohesive areas with epithelioid tumour cells; other areas revealed tumour cells with bright eosinophilic cytoplasm, suggesting a squamous differentiation. Furthermore, immunohistochemistry (IHC) analyses for smooth muscle actin and muscle-specific actin were moderately positive (consistent with sarcomatoid differentiation). IHC analyses also were positive for AE1/AE3, high-molecular-weight keratin (HMWK) 34BE12, and vimentin (fig. 3), supporting the diagnosis of SC.

Bottom Line: SC is associated with a poor prognosis and advanced disease at presentation.Treatment options are generally aggressive but risky, and frequently yield poor results.Due to the rarity of SC, there has been little focus on the development of improved treatment options.

View Article: PubMed Central - PubMed

Affiliation: Oral and Maxillofacial Surgery, Queensland Health, The University of Queensland, Herston, Qld., Australia.

ABSTRACT
Sarcomatous carcinomas (SCs) are rare tumours that contain malignant cells with epithelial and mesenchymal characteristics. SC rarely presents in the head and neck, and occurs even less often in the orbit. Only 8 cases of SCs located in the orbit or affecting the globe function have been described in the English literature. Here, we report a case of SC affecting the right orbit. SC is associated with a poor prognosis and advanced disease at presentation. Diagnosis is difficult, as histology often fails to definitively identify SC, necessitating a wide panel of molecular/immunological markers. Treatment options are generally aggressive but risky, and frequently yield poor results. Due to the rarity of SC, there has been little focus on the development of improved treatment options.

No MeSH data available.


Related in: MedlinePlus