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Muco-bioadhesive containing ginger officinal e extract in the management of recurrent aphthous stomatitis: A randomized clinical study.

Haghpanah P, Moghadamnia AA, Zarghami A, Motallebnejad M - Caspian J Intern Med (2015)

Bottom Line: Significant reduction in pain was observed on day 5 between placebo (using base bioadhesives) and without treatment periods at the first phase of the study (4.53 vs. 3.27; P=0.038. ( Reduction in inflamed halo diameters was significant on day 1 between without treatment and ginger containing bioadhesives )46.73 vs 28.67; P=0.044).Other variables such as the diameter of ulcers did not indicate any significant differences in both periods.However, its efficacy on ulcer diameter, inflamed halo and healing time was not significantly different compared to the results of the placebo received period.

View Article: PubMed Central - PubMed

Affiliation: Department of Periodontology, School of Dentistry, Babol University of Medical Sciences, Babol, Iran.

ABSTRACT

Background: Recurrent aphthous stomatitis (RAS) is the most common oral mucosal lesions in the general population. Various treatment modalities have been used; but no specific therapy proved to be definitive. Ginger Officinale (ginger) indicated to have anti-inflammatory properties in herbal medicine. Thus, this study aimed to evaluate the efficacy of ginger containing bioadhesive in the treatment of aphthous ulcers.

Methods: In this randomized double-blind placebo-controlled trial, 15 patients were enrolled. The clinical efficacy of the mucoadhessive on pain, inflammatory zone and ulcer's diameter in the test period was compared with that of the base treatment and no treatment periods during 10 days of study.

Results: Significant reduction in pain was observed on day 5 between placebo (using base bioadhesives) and without treatment periods at the first phase of the study (4.53 vs. 3.27; P=0.038. ( Reduction in inflamed halo diameters was significant on day 1 between without treatment and ginger containing bioadhesives )46.73 vs 28.67; P=0.044). Other variables such as the diameter of ulcers did not indicate any significant differences in both periods.

Conclusion: This study indicated that ginger bioadhesive is capable to relieve pain of RAS. However, its efficacy on ulcer diameter, inflamed halo and healing time was not significantly different compared to the results of the placebo received period.

No MeSH data available.


Related in: MedlinePlus

Trend of wound diameter on days 1, 3, 5 and 7 of observation in three different periods of treatment
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Figure 3: Trend of wound diameter on days 1, 3, 5 and 7 of observation in three different periods of treatment

Mentions: According to figures 2 and 3 that illustrate the results of Friedman test, the average diameter of inflammatory and lesion zones showed significant difference in intra-group comparisons daily of the three periods of the study (P=0.045); also, in ginger received episode, a significant decrease in the diameter of inflammatory zone was observed on the first day of treatment with ginger in comparison with the period without treatment (p<0.05). The mean and SD of pain relief duration (day) in the three periods of ginger, placebo and without treatment received was 14.2±3.21, 15.13±3.44, and 13.87±4.22, respectively. Therefore, no significant difference was observed in pain relief duration among the three periods of treatment (p=0.351).


Muco-bioadhesive containing ginger officinal e extract in the management of recurrent aphthous stomatitis: A randomized clinical study.

Haghpanah P, Moghadamnia AA, Zarghami A, Motallebnejad M - Caspian J Intern Med (2015)

Trend of wound diameter on days 1, 3, 5 and 7 of observation in three different periods of treatment
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4478111&req=5

Figure 3: Trend of wound diameter on days 1, 3, 5 and 7 of observation in three different periods of treatment
Mentions: According to figures 2 and 3 that illustrate the results of Friedman test, the average diameter of inflammatory and lesion zones showed significant difference in intra-group comparisons daily of the three periods of the study (P=0.045); also, in ginger received episode, a significant decrease in the diameter of inflammatory zone was observed on the first day of treatment with ginger in comparison with the period without treatment (p<0.05). The mean and SD of pain relief duration (day) in the three periods of ginger, placebo and without treatment received was 14.2±3.21, 15.13±3.44, and 13.87±4.22, respectively. Therefore, no significant difference was observed in pain relief duration among the three periods of treatment (p=0.351).

Bottom Line: Significant reduction in pain was observed on day 5 between placebo (using base bioadhesives) and without treatment periods at the first phase of the study (4.53 vs. 3.27; P=0.038. ( Reduction in inflamed halo diameters was significant on day 1 between without treatment and ginger containing bioadhesives )46.73 vs 28.67; P=0.044).Other variables such as the diameter of ulcers did not indicate any significant differences in both periods.However, its efficacy on ulcer diameter, inflamed halo and healing time was not significantly different compared to the results of the placebo received period.

View Article: PubMed Central - PubMed

Affiliation: Department of Periodontology, School of Dentistry, Babol University of Medical Sciences, Babol, Iran.

ABSTRACT

Background: Recurrent aphthous stomatitis (RAS) is the most common oral mucosal lesions in the general population. Various treatment modalities have been used; but no specific therapy proved to be definitive. Ginger Officinale (ginger) indicated to have anti-inflammatory properties in herbal medicine. Thus, this study aimed to evaluate the efficacy of ginger containing bioadhesive in the treatment of aphthous ulcers.

Methods: In this randomized double-blind placebo-controlled trial, 15 patients were enrolled. The clinical efficacy of the mucoadhessive on pain, inflammatory zone and ulcer's diameter in the test period was compared with that of the base treatment and no treatment periods during 10 days of study.

Results: Significant reduction in pain was observed on day 5 between placebo (using base bioadhesives) and without treatment periods at the first phase of the study (4.53 vs. 3.27; P=0.038. ( Reduction in inflamed halo diameters was significant on day 1 between without treatment and ginger containing bioadhesives )46.73 vs 28.67; P=0.044). Other variables such as the diameter of ulcers did not indicate any significant differences in both periods.

Conclusion: This study indicated that ginger bioadhesive is capable to relieve pain of RAS. However, its efficacy on ulcer diameter, inflamed halo and healing time was not significantly different compared to the results of the placebo received period.

No MeSH data available.


Related in: MedlinePlus