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The Cooperative Landscape of Multinational Clinical Trials.

Hsiehchen D, Espinoza M, Hsieh A - PLoS ONE (2015)

Bottom Line: The scale and nature of cooperative efforts spanning geopolitical borders in clinical research have not been elucidated to date.In a cross-sectional study of 110,428 interventional trials registered in Clinicaltrials.gov, we characterized the evolution, trial demographics, and network properties of multinational clinical research.Performances in network centrality measures also highlight the differential contribution of nations in the global research network.

View Article: PubMed Central - PubMed

Affiliation: Mount Auburn Hospital, Cambridge, Massachusetts 02138, United States of America.

ABSTRACT
The scale and nature of cooperative efforts spanning geopolitical borders in clinical research have not been elucidated to date. In a cross-sectional study of 110,428 interventional trials registered in Clinicaltrials.gov, we characterized the evolution, trial demographics, and network properties of multinational clinical research. We reveal that the relative growth of international collaboratives has remained stagnant in the last two decades, although clinical trials have evolved to become much larger in scale. Multinational clinical trials are also characterized by higher patient enrollments, industry funding, and specific clinical disciplines including oncology and infectious disease. Network analyses demonstrate temporal shifts in collaboration patterns between countries and world regions, with developing nations now collaborating more within themselves, although Europe remains the dominant contributor to multinational clinical trials worldwide. Performances in network centrality measures also highlight the differential contribution of nations in the global research network. A city-level clinical trial network analysis further demonstrates how collaborative ties decline with physical distance. This study clarifies evolving themes and highlights potential growth mechanisms and barriers in multinational clinical trials, which may be useful in evaluating the role of national and local policies in organizing transborder efforts in clinical endeavors.

No MeSH data available.


Related in: MedlinePlus

Growth of clinical trials.(A) Levels of clinical trials associated with single institutes, domestic collaborations, and multinational collaborations at specified starting years. The decline in trials in 2013 is due to the fact that the most recent database update from the Aggregate Analysis of Clinicaltrails.gov was from March of 2014 (which only included trials registered up until September 2013). (B) Data from Panel A as a percentage of all trials starting within the same year.
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pone.0130930.g002: Growth of clinical trials.(A) Levels of clinical trials associated with single institutes, domestic collaborations, and multinational collaborations at specified starting years. The decline in trials in 2013 is due to the fact that the most recent database update from the Aggregate Analysis of Clinicaltrails.gov was from March of 2014 (which only included trials registered up until September 2013). (B) Data from Panel A as a percentage of all trials starting within the same year.

Mentions: The number of registered trials attributed to either a single institute, domestic collaboration (composed of more than one institute within a country), or multinational collaboration (composed of at least two institutes each in a unique country) in ClinicalTrials.gov has grown considerably, particularly over the last decade (Fig 2A). However, in contrast to the increasing proportion of scholarly output credited to international collaborations across many research disciplines, relative levels of multinational clinical trials remained largely static (Fig 2B) [2, 6, 18].


The Cooperative Landscape of Multinational Clinical Trials.

Hsiehchen D, Espinoza M, Hsieh A - PLoS ONE (2015)

Growth of clinical trials.(A) Levels of clinical trials associated with single institutes, domestic collaborations, and multinational collaborations at specified starting years. The decline in trials in 2013 is due to the fact that the most recent database update from the Aggregate Analysis of Clinicaltrails.gov was from March of 2014 (which only included trials registered up until September 2013). (B) Data from Panel A as a percentage of all trials starting within the same year.
© Copyright Policy
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4478022&req=5

pone.0130930.g002: Growth of clinical trials.(A) Levels of clinical trials associated with single institutes, domestic collaborations, and multinational collaborations at specified starting years. The decline in trials in 2013 is due to the fact that the most recent database update from the Aggregate Analysis of Clinicaltrails.gov was from March of 2014 (which only included trials registered up until September 2013). (B) Data from Panel A as a percentage of all trials starting within the same year.
Mentions: The number of registered trials attributed to either a single institute, domestic collaboration (composed of more than one institute within a country), or multinational collaboration (composed of at least two institutes each in a unique country) in ClinicalTrials.gov has grown considerably, particularly over the last decade (Fig 2A). However, in contrast to the increasing proportion of scholarly output credited to international collaborations across many research disciplines, relative levels of multinational clinical trials remained largely static (Fig 2B) [2, 6, 18].

Bottom Line: The scale and nature of cooperative efforts spanning geopolitical borders in clinical research have not been elucidated to date.In a cross-sectional study of 110,428 interventional trials registered in Clinicaltrials.gov, we characterized the evolution, trial demographics, and network properties of multinational clinical research.Performances in network centrality measures also highlight the differential contribution of nations in the global research network.

View Article: PubMed Central - PubMed

Affiliation: Mount Auburn Hospital, Cambridge, Massachusetts 02138, United States of America.

ABSTRACT
The scale and nature of cooperative efforts spanning geopolitical borders in clinical research have not been elucidated to date. In a cross-sectional study of 110,428 interventional trials registered in Clinicaltrials.gov, we characterized the evolution, trial demographics, and network properties of multinational clinical research. We reveal that the relative growth of international collaboratives has remained stagnant in the last two decades, although clinical trials have evolved to become much larger in scale. Multinational clinical trials are also characterized by higher patient enrollments, industry funding, and specific clinical disciplines including oncology and infectious disease. Network analyses demonstrate temporal shifts in collaboration patterns between countries and world regions, with developing nations now collaborating more within themselves, although Europe remains the dominant contributor to multinational clinical trials worldwide. Performances in network centrality measures also highlight the differential contribution of nations in the global research network. A city-level clinical trial network analysis further demonstrates how collaborative ties decline with physical distance. This study clarifies evolving themes and highlights potential growth mechanisms and barriers in multinational clinical trials, which may be useful in evaluating the role of national and local policies in organizing transborder efforts in clinical endeavors.

No MeSH data available.


Related in: MedlinePlus