Limits...
The Cooperative Landscape of Multinational Clinical Trials.

Hsiehchen D, Espinoza M, Hsieh A - PLoS ONE (2015)

Bottom Line: The scale and nature of cooperative efforts spanning geopolitical borders in clinical research have not been elucidated to date.In a cross-sectional study of 110,428 interventional trials registered in Clinicaltrials.gov, we characterized the evolution, trial demographics, and network properties of multinational clinical research.Performances in network centrality measures also highlight the differential contribution of nations in the global research network.

View Article: PubMed Central - PubMed

Affiliation: Mount Auburn Hospital, Cambridge, Massachusetts 02138, United States of America.

ABSTRACT
The scale and nature of cooperative efforts spanning geopolitical borders in clinical research have not been elucidated to date. In a cross-sectional study of 110,428 interventional trials registered in Clinicaltrials.gov, we characterized the evolution, trial demographics, and network properties of multinational clinical research. We reveal that the relative growth of international collaboratives has remained stagnant in the last two decades, although clinical trials have evolved to become much larger in scale. Multinational clinical trials are also characterized by higher patient enrollments, industry funding, and specific clinical disciplines including oncology and infectious disease. Network analyses demonstrate temporal shifts in collaboration patterns between countries and world regions, with developing nations now collaborating more within themselves, although Europe remains the dominant contributor to multinational clinical trials worldwide. Performances in network centrality measures also highlight the differential contribution of nations in the global research network. A city-level clinical trial network analysis further demonstrates how collaborative ties decline with physical distance. This study clarifies evolving themes and highlights potential growth mechanisms and barriers in multinational clinical trials, which may be useful in evaluating the role of national and local policies in organizing transborder efforts in clinical endeavors.

No MeSH data available.


Related in: MedlinePlus

The selection of clinical trials from ClinicalTrials.gov.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4478022&req=5

pone.0130930.g001: The selection of clinical trials from ClinicalTrials.gov.

Mentions: We downloaded the entire Aggregate Analysis of ClinicalTrials.gov database (updated on September 27, 2013) including data for 152,611 clinical trials from the Clinical Trials Transformation Initiative portal (http://www.ctti-clinicaltrials.org). We focused on clinical trials with start years from 1995 and onwards and included only interventional trials (identified through the study type field) without missing data regarding the location of clinical sites enrolling patients (hereafter referred to as an institute), yielding 110,428 studies (Fig 1). While multiple clinical trial registries exist, we performed our analyses on ClinicalTrials.gov given its international scope, large scale, and accessibility.


The Cooperative Landscape of Multinational Clinical Trials.

Hsiehchen D, Espinoza M, Hsieh A - PLoS ONE (2015)

The selection of clinical trials from ClinicalTrials.gov.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4478022&req=5

pone.0130930.g001: The selection of clinical trials from ClinicalTrials.gov.
Mentions: We downloaded the entire Aggregate Analysis of ClinicalTrials.gov database (updated on September 27, 2013) including data for 152,611 clinical trials from the Clinical Trials Transformation Initiative portal (http://www.ctti-clinicaltrials.org). We focused on clinical trials with start years from 1995 and onwards and included only interventional trials (identified through the study type field) without missing data regarding the location of clinical sites enrolling patients (hereafter referred to as an institute), yielding 110,428 studies (Fig 1). While multiple clinical trial registries exist, we performed our analyses on ClinicalTrials.gov given its international scope, large scale, and accessibility.

Bottom Line: The scale and nature of cooperative efforts spanning geopolitical borders in clinical research have not been elucidated to date.In a cross-sectional study of 110,428 interventional trials registered in Clinicaltrials.gov, we characterized the evolution, trial demographics, and network properties of multinational clinical research.Performances in network centrality measures also highlight the differential contribution of nations in the global research network.

View Article: PubMed Central - PubMed

Affiliation: Mount Auburn Hospital, Cambridge, Massachusetts 02138, United States of America.

ABSTRACT
The scale and nature of cooperative efforts spanning geopolitical borders in clinical research have not been elucidated to date. In a cross-sectional study of 110,428 interventional trials registered in Clinicaltrials.gov, we characterized the evolution, trial demographics, and network properties of multinational clinical research. We reveal that the relative growth of international collaboratives has remained stagnant in the last two decades, although clinical trials have evolved to become much larger in scale. Multinational clinical trials are also characterized by higher patient enrollments, industry funding, and specific clinical disciplines including oncology and infectious disease. Network analyses demonstrate temporal shifts in collaboration patterns between countries and world regions, with developing nations now collaborating more within themselves, although Europe remains the dominant contributor to multinational clinical trials worldwide. Performances in network centrality measures also highlight the differential contribution of nations in the global research network. A city-level clinical trial network analysis further demonstrates how collaborative ties decline with physical distance. This study clarifies evolving themes and highlights potential growth mechanisms and barriers in multinational clinical trials, which may be useful in evaluating the role of national and local policies in organizing transborder efforts in clinical endeavors.

No MeSH data available.


Related in: MedlinePlus