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Lung and Nodal Involvement in Nontuberculous Mycobacterial Disease: PET/CT Role.

Del Giudice G, Bianco A, Cennamo A, Santoro G, Bifulco M, Marzo C, Mazzarella G - Biomed Res Int (2015)

Bottom Line: Systematic use of (18)F-FDG PET/CT has the potential to simultaneously assess both pulmonary and lymph node involvement in nontuberculous mycobacterial (NTM) lung infection.The aim of the study was to evaluate the role of (18)F-FDG PET/CT in the assessment of both mediastinal lymph nodes and lung involvement in NTM patients compared with active tuberculosis (TB) patients. 26 patients with pulmonary NTM disease were selected; six consecutive patients had undergone (18)F-FDG PET/CT and data was compared with 6 active TB patients.Pulmonary lesions in TB showed an average SUV max value of 10,07 ± 6,45 (range 1,20 to 22,75) whilst involved mediastinal lymph nodes exhibited a mean SUV max value of 7,23 ± 3,03 (range 1,78 to 15,72).

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiothoracic and Respiratory Sciences, Second University of Naples, "dei Colli" Hospital, Via Leonardo Bianchi, 80131 Naples, Italy.

ABSTRACT

Introduction: Systematic use of (18)F-FDG PET/CT has the potential to simultaneously assess both pulmonary and lymph node involvement in nontuberculous mycobacterial (NTM) lung infection.

Objective: The aim of the study was to evaluate the role of (18)F-FDG PET/CT in the assessment of both mediastinal lymph nodes and lung involvement in NTM patients compared with active tuberculosis (TB) patients.

Methods: 26 patients with pulmonary NTM disease were selected; six consecutive patients had undergone (18)F-FDG PET/CT and data was compared with 6 active TB patients.

Results: NTM exhibited different radiological lung patterns with an average SUV max value at PET/CT scan of 3,59 ± 2,32 (range 1,14 to 9,01) on pulmonary lesions and a mean value of SUV max 1,21 ± 0,29 (range 0,90 to 1,70) on mediastinal lymph nodes. Pulmonary lesions in TB showed an average SUV max value of 10,07 ± 6,45 (range 1,20 to 22,75) whilst involved mediastinal lymph nodes exhibited a mean SUV max value of 7,23 ± 3,03 (range 1,78 to 15,72).

Conclusions: The differences in PET uptake in a broad range of lung lesions and lymph nodes between NTM and M. tuberculosis patients suggest a potential role for PET/CT scan in the diagnosis and management of pulmonary mycobacterial disease.

No MeSH data available.


Related in: MedlinePlus

Comparison between average SUV max of mediastinal lymph nodes in NTM and M. tuberculosis patients.
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fig6: Comparison between average SUV max of mediastinal lymph nodes in NTM and M. tuberculosis patients.

Mentions: Patients with active TB showed a mean value of SUV max of mediastinal lymph nodes equal to 7,23 ± 3,03 (range 1,78 to 15,72), significantly higher than the average value of SUV max 1,21 ± 0,29 (range 0,90 to 1,70); P = 2, 62 × 10−6 detected in patients with NTM (Figure 6). The average SUV max of lung lesions in patients with active TB was equal to 10,07 ± 6,45 (range 1,20 to 22,75) and significantly higher than the average SUV max of lung lesions in NTM patients 3,59 ± 2,32 (range 1,14 to 9,01); P = 0,0043 (Figure 7).


Lung and Nodal Involvement in Nontuberculous Mycobacterial Disease: PET/CT Role.

Del Giudice G, Bianco A, Cennamo A, Santoro G, Bifulco M, Marzo C, Mazzarella G - Biomed Res Int (2015)

Comparison between average SUV max of mediastinal lymph nodes in NTM and M. tuberculosis patients.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4477428&req=5

fig6: Comparison between average SUV max of mediastinal lymph nodes in NTM and M. tuberculosis patients.
Mentions: Patients with active TB showed a mean value of SUV max of mediastinal lymph nodes equal to 7,23 ± 3,03 (range 1,78 to 15,72), significantly higher than the average value of SUV max 1,21 ± 0,29 (range 0,90 to 1,70); P = 2, 62 × 10−6 detected in patients with NTM (Figure 6). The average SUV max of lung lesions in patients with active TB was equal to 10,07 ± 6,45 (range 1,20 to 22,75) and significantly higher than the average SUV max of lung lesions in NTM patients 3,59 ± 2,32 (range 1,14 to 9,01); P = 0,0043 (Figure 7).

Bottom Line: Systematic use of (18)F-FDG PET/CT has the potential to simultaneously assess both pulmonary and lymph node involvement in nontuberculous mycobacterial (NTM) lung infection.The aim of the study was to evaluate the role of (18)F-FDG PET/CT in the assessment of both mediastinal lymph nodes and lung involvement in NTM patients compared with active tuberculosis (TB) patients. 26 patients with pulmonary NTM disease were selected; six consecutive patients had undergone (18)F-FDG PET/CT and data was compared with 6 active TB patients.Pulmonary lesions in TB showed an average SUV max value of 10,07 ± 6,45 (range 1,20 to 22,75) whilst involved mediastinal lymph nodes exhibited a mean SUV max value of 7,23 ± 3,03 (range 1,78 to 15,72).

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiothoracic and Respiratory Sciences, Second University of Naples, "dei Colli" Hospital, Via Leonardo Bianchi, 80131 Naples, Italy.

ABSTRACT

Introduction: Systematic use of (18)F-FDG PET/CT has the potential to simultaneously assess both pulmonary and lymph node involvement in nontuberculous mycobacterial (NTM) lung infection.

Objective: The aim of the study was to evaluate the role of (18)F-FDG PET/CT in the assessment of both mediastinal lymph nodes and lung involvement in NTM patients compared with active tuberculosis (TB) patients.

Methods: 26 patients with pulmonary NTM disease were selected; six consecutive patients had undergone (18)F-FDG PET/CT and data was compared with 6 active TB patients.

Results: NTM exhibited different radiological lung patterns with an average SUV max value at PET/CT scan of 3,59 ± 2,32 (range 1,14 to 9,01) on pulmonary lesions and a mean value of SUV max 1,21 ± 0,29 (range 0,90 to 1,70) on mediastinal lymph nodes. Pulmonary lesions in TB showed an average SUV max value of 10,07 ± 6,45 (range 1,20 to 22,75) whilst involved mediastinal lymph nodes exhibited a mean SUV max value of 7,23 ± 3,03 (range 1,78 to 15,72).

Conclusions: The differences in PET uptake in a broad range of lung lesions and lymph nodes between NTM and M. tuberculosis patients suggest a potential role for PET/CT scan in the diagnosis and management of pulmonary mycobacterial disease.

No MeSH data available.


Related in: MedlinePlus