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Lung and Nodal Involvement in Nontuberculous Mycobacterial Disease: PET/CT Role.

Del Giudice G, Bianco A, Cennamo A, Santoro G, Bifulco M, Marzo C, Mazzarella G - Biomed Res Int (2015)

Bottom Line: Systematic use of (18)F-FDG PET/CT has the potential to simultaneously assess both pulmonary and lymph node involvement in nontuberculous mycobacterial (NTM) lung infection.The aim of the study was to evaluate the role of (18)F-FDG PET/CT in the assessment of both mediastinal lymph nodes and lung involvement in NTM patients compared with active tuberculosis (TB) patients. 26 patients with pulmonary NTM disease were selected; six consecutive patients had undergone (18)F-FDG PET/CT and data was compared with 6 active TB patients.Pulmonary lesions in TB showed an average SUV max value of 10,07 ± 6,45 (range 1,20 to 22,75) whilst involved mediastinal lymph nodes exhibited a mean SUV max value of 7,23 ± 3,03 (range 1,78 to 15,72).

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiothoracic and Respiratory Sciences, Second University of Naples, "dei Colli" Hospital, Via Leonardo Bianchi, 80131 Naples, Italy.

ABSTRACT

Introduction: Systematic use of (18)F-FDG PET/CT has the potential to simultaneously assess both pulmonary and lymph node involvement in nontuberculous mycobacterial (NTM) lung infection.

Objective: The aim of the study was to evaluate the role of (18)F-FDG PET/CT in the assessment of both mediastinal lymph nodes and lung involvement in NTM patients compared with active tuberculosis (TB) patients.

Methods: 26 patients with pulmonary NTM disease were selected; six consecutive patients had undergone (18)F-FDG PET/CT and data was compared with 6 active TB patients.

Results: NTM exhibited different radiological lung patterns with an average SUV max value at PET/CT scan of 3,59 ± 2,32 (range 1,14 to 9,01) on pulmonary lesions and a mean value of SUV max 1,21 ± 0,29 (range 0,90 to 1,70) on mediastinal lymph nodes. Pulmonary lesions in TB showed an average SUV max value of 10,07 ± 6,45 (range 1,20 to 22,75) whilst involved mediastinal lymph nodes exhibited a mean SUV max value of 7,23 ± 3,03 (range 1,78 to 15,72).

Conclusions: The differences in PET uptake in a broad range of lung lesions and lymph nodes between NTM and M. tuberculosis patients suggest a potential role for PET/CT scan in the diagnosis and management of pulmonary mycobacterial disease.

No MeSH data available.


Related in: MedlinePlus

M. tuberculosis infection. Massive area of high metabolic activity, SUV max 19.55, lower right lobe. Related to patient 11 (PET/CT. Courtesy “V. Monaldi” Hospital).
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fig4: M. tuberculosis infection. Massive area of high metabolic activity, SUV max 19.55, lower right lobe. Related to patient 11 (PET/CT. Courtesy “V. Monaldi” Hospital).

Mentions: At CT scan more than one radiological pattern was simultaneously found in active tuberculosis patients. CT findings included parenchymal consolidation or ground glass opacity (GGO) (n = 6) with SUV max between 1,20 and 22,75, excavation (n = 3) SUV max 4,19–15,10, and miliary (n = 1) SUV max 8,25, with lymph node involvement; in one case a combination of nodular consolidation PET-positive and bilateral pleural parietobasal effusion PET-negative was identified. PET/CT showed the presence (for all of 6 patients) of extensive areas of high metabolic activity (SUV max range 1,20–22,75 (Figure 4) and average values of SUV max of 10,07 ± 6,45).


Lung and Nodal Involvement in Nontuberculous Mycobacterial Disease: PET/CT Role.

Del Giudice G, Bianco A, Cennamo A, Santoro G, Bifulco M, Marzo C, Mazzarella G - Biomed Res Int (2015)

M. tuberculosis infection. Massive area of high metabolic activity, SUV max 19.55, lower right lobe. Related to patient 11 (PET/CT. Courtesy “V. Monaldi” Hospital).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4477428&req=5

fig4: M. tuberculosis infection. Massive area of high metabolic activity, SUV max 19.55, lower right lobe. Related to patient 11 (PET/CT. Courtesy “V. Monaldi” Hospital).
Mentions: At CT scan more than one radiological pattern was simultaneously found in active tuberculosis patients. CT findings included parenchymal consolidation or ground glass opacity (GGO) (n = 6) with SUV max between 1,20 and 22,75, excavation (n = 3) SUV max 4,19–15,10, and miliary (n = 1) SUV max 8,25, with lymph node involvement; in one case a combination of nodular consolidation PET-positive and bilateral pleural parietobasal effusion PET-negative was identified. PET/CT showed the presence (for all of 6 patients) of extensive areas of high metabolic activity (SUV max range 1,20–22,75 (Figure 4) and average values of SUV max of 10,07 ± 6,45).

Bottom Line: Systematic use of (18)F-FDG PET/CT has the potential to simultaneously assess both pulmonary and lymph node involvement in nontuberculous mycobacterial (NTM) lung infection.The aim of the study was to evaluate the role of (18)F-FDG PET/CT in the assessment of both mediastinal lymph nodes and lung involvement in NTM patients compared with active tuberculosis (TB) patients. 26 patients with pulmonary NTM disease were selected; six consecutive patients had undergone (18)F-FDG PET/CT and data was compared with 6 active TB patients.Pulmonary lesions in TB showed an average SUV max value of 10,07 ± 6,45 (range 1,20 to 22,75) whilst involved mediastinal lymph nodes exhibited a mean SUV max value of 7,23 ± 3,03 (range 1,78 to 15,72).

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiothoracic and Respiratory Sciences, Second University of Naples, "dei Colli" Hospital, Via Leonardo Bianchi, 80131 Naples, Italy.

ABSTRACT

Introduction: Systematic use of (18)F-FDG PET/CT has the potential to simultaneously assess both pulmonary and lymph node involvement in nontuberculous mycobacterial (NTM) lung infection.

Objective: The aim of the study was to evaluate the role of (18)F-FDG PET/CT in the assessment of both mediastinal lymph nodes and lung involvement in NTM patients compared with active tuberculosis (TB) patients.

Methods: 26 patients with pulmonary NTM disease were selected; six consecutive patients had undergone (18)F-FDG PET/CT and data was compared with 6 active TB patients.

Results: NTM exhibited different radiological lung patterns with an average SUV max value at PET/CT scan of 3,59 ± 2,32 (range 1,14 to 9,01) on pulmonary lesions and a mean value of SUV max 1,21 ± 0,29 (range 0,90 to 1,70) on mediastinal lymph nodes. Pulmonary lesions in TB showed an average SUV max value of 10,07 ± 6,45 (range 1,20 to 22,75) whilst involved mediastinal lymph nodes exhibited a mean SUV max value of 7,23 ± 3,03 (range 1,78 to 15,72).

Conclusions: The differences in PET uptake in a broad range of lung lesions and lymph nodes between NTM and M. tuberculosis patients suggest a potential role for PET/CT scan in the diagnosis and management of pulmonary mycobacterial disease.

No MeSH data available.


Related in: MedlinePlus