Limits...
Lung and Nodal Involvement in Nontuberculous Mycobacterial Disease: PET/CT Role.

Del Giudice G, Bianco A, Cennamo A, Santoro G, Bifulco M, Marzo C, Mazzarella G - Biomed Res Int (2015)

Bottom Line: Systematic use of (18)F-FDG PET/CT has the potential to simultaneously assess both pulmonary and lymph node involvement in nontuberculous mycobacterial (NTM) lung infection.The aim of the study was to evaluate the role of (18)F-FDG PET/CT in the assessment of both mediastinal lymph nodes and lung involvement in NTM patients compared with active tuberculosis (TB) patients. 26 patients with pulmonary NTM disease were selected; six consecutive patients had undergone (18)F-FDG PET/CT and data was compared with 6 active TB patients.Pulmonary lesions in TB showed an average SUV max value of 10,07 ± 6,45 (range 1,20 to 22,75) whilst involved mediastinal lymph nodes exhibited a mean SUV max value of 7,23 ± 3,03 (range 1,78 to 15,72).

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiothoracic and Respiratory Sciences, Second University of Naples, "dei Colli" Hospital, Via Leonardo Bianchi, 80131 Naples, Italy.

ABSTRACT

Introduction: Systematic use of (18)F-FDG PET/CT has the potential to simultaneously assess both pulmonary and lymph node involvement in nontuberculous mycobacterial (NTM) lung infection.

Objective: The aim of the study was to evaluate the role of (18)F-FDG PET/CT in the assessment of both mediastinal lymph nodes and lung involvement in NTM patients compared with active tuberculosis (TB) patients.

Methods: 26 patients with pulmonary NTM disease were selected; six consecutive patients had undergone (18)F-FDG PET/CT and data was compared with 6 active TB patients.

Results: NTM exhibited different radiological lung patterns with an average SUV max value at PET/CT scan of 3,59 ± 2,32 (range 1,14 to 9,01) on pulmonary lesions and a mean value of SUV max 1,21 ± 0,29 (range 0,90 to 1,70) on mediastinal lymph nodes. Pulmonary lesions in TB showed an average SUV max value of 10,07 ± 6,45 (range 1,20 to 22,75) whilst involved mediastinal lymph nodes exhibited a mean SUV max value of 7,23 ± 3,03 (range 1,78 to 15,72).

Conclusions: The differences in PET uptake in a broad range of lung lesions and lymph nodes between NTM and M. tuberculosis patients suggest a potential role for PET/CT scan in the diagnosis and management of pulmonary mycobacterial disease.

No MeSH data available.


Related in: MedlinePlus

M. kansasii infection, cavitary lesions in the right upper lobe and in the apical segment of the right lower lobe and left upper lobe, SUV max 5.36. Related to patient 3 (PET/CT. Courtesy “V. Monaldi” Hospital).
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4477428&req=5

fig1: M. kansasii infection, cavitary lesions in the right upper lobe and in the apical segment of the right lower lobe and left upper lobe, SUV max 5.36. Related to patient 3 (PET/CT. Courtesy “V. Monaldi” Hospital).

Mentions: NTM patients CT scans showed nodular or pseudonodular involvement (n = 3), parenchymal consolidation (n = 2), pleural thickening (n = 2), calcified sequelae (n = 2), cavitary lesions (n = 2), and pleural effusion (n = 1). More than one radiological pattern was simultaneously found in five NTM patients. PET/CT scan in NTM patients showed areas of consolidation or parenchymal thickening with SUV max between 1,64 and 9,01 (n = 3), pleural thickenings with SUV max that ranged from 1,14 to 1,80 (n = 2), subpleural nodular lesions with SUV max 2,7–4,5 (n = 1), and multiple cavitary lesions with SUV max between 2,60 and 5,36 (n = 1) (Figure 1), and in one patient a baseline monolateral pleural effusion with maximum uptake (SUV max of 6,06) was observed.


Lung and Nodal Involvement in Nontuberculous Mycobacterial Disease: PET/CT Role.

Del Giudice G, Bianco A, Cennamo A, Santoro G, Bifulco M, Marzo C, Mazzarella G - Biomed Res Int (2015)

M. kansasii infection, cavitary lesions in the right upper lobe and in the apical segment of the right lower lobe and left upper lobe, SUV max 5.36. Related to patient 3 (PET/CT. Courtesy “V. Monaldi” Hospital).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4477428&req=5

fig1: M. kansasii infection, cavitary lesions in the right upper lobe and in the apical segment of the right lower lobe and left upper lobe, SUV max 5.36. Related to patient 3 (PET/CT. Courtesy “V. Monaldi” Hospital).
Mentions: NTM patients CT scans showed nodular or pseudonodular involvement (n = 3), parenchymal consolidation (n = 2), pleural thickening (n = 2), calcified sequelae (n = 2), cavitary lesions (n = 2), and pleural effusion (n = 1). More than one radiological pattern was simultaneously found in five NTM patients. PET/CT scan in NTM patients showed areas of consolidation or parenchymal thickening with SUV max between 1,64 and 9,01 (n = 3), pleural thickenings with SUV max that ranged from 1,14 to 1,80 (n = 2), subpleural nodular lesions with SUV max 2,7–4,5 (n = 1), and multiple cavitary lesions with SUV max between 2,60 and 5,36 (n = 1) (Figure 1), and in one patient a baseline monolateral pleural effusion with maximum uptake (SUV max of 6,06) was observed.

Bottom Line: Systematic use of (18)F-FDG PET/CT has the potential to simultaneously assess both pulmonary and lymph node involvement in nontuberculous mycobacterial (NTM) lung infection.The aim of the study was to evaluate the role of (18)F-FDG PET/CT in the assessment of both mediastinal lymph nodes and lung involvement in NTM patients compared with active tuberculosis (TB) patients. 26 patients with pulmonary NTM disease were selected; six consecutive patients had undergone (18)F-FDG PET/CT and data was compared with 6 active TB patients.Pulmonary lesions in TB showed an average SUV max value of 10,07 ± 6,45 (range 1,20 to 22,75) whilst involved mediastinal lymph nodes exhibited a mean SUV max value of 7,23 ± 3,03 (range 1,78 to 15,72).

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiothoracic and Respiratory Sciences, Second University of Naples, "dei Colli" Hospital, Via Leonardo Bianchi, 80131 Naples, Italy.

ABSTRACT

Introduction: Systematic use of (18)F-FDG PET/CT has the potential to simultaneously assess both pulmonary and lymph node involvement in nontuberculous mycobacterial (NTM) lung infection.

Objective: The aim of the study was to evaluate the role of (18)F-FDG PET/CT in the assessment of both mediastinal lymph nodes and lung involvement in NTM patients compared with active tuberculosis (TB) patients.

Methods: 26 patients with pulmonary NTM disease were selected; six consecutive patients had undergone (18)F-FDG PET/CT and data was compared with 6 active TB patients.

Results: NTM exhibited different radiological lung patterns with an average SUV max value at PET/CT scan of 3,59 ± 2,32 (range 1,14 to 9,01) on pulmonary lesions and a mean value of SUV max 1,21 ± 0,29 (range 0,90 to 1,70) on mediastinal lymph nodes. Pulmonary lesions in TB showed an average SUV max value of 10,07 ± 6,45 (range 1,20 to 22,75) whilst involved mediastinal lymph nodes exhibited a mean SUV max value of 7,23 ± 3,03 (range 1,78 to 15,72).

Conclusions: The differences in PET uptake in a broad range of lung lesions and lymph nodes between NTM and M. tuberculosis patients suggest a potential role for PET/CT scan in the diagnosis and management of pulmonary mycobacterial disease.

No MeSH data available.


Related in: MedlinePlus