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Nontuberculous Mycobacteria Isolation from Clinical and Environmental Samples in Iran: Twenty Years of Surveillance.

Velayati AA, Farnia P, Mozafari M, Mirsaeidi M - Biomed Res Int (2015)

Bottom Line: These results emphasize the potential importance of NTM as well as the underestimation of NTM frequency in Iran.NTM is an important clinical problem associated with significant morbidity and mortality in Iran.Continued research is needed from both clinical and environmental sources to help clinicians and researchers better understand and address NTM treatment and prevention.

View Article: PubMed Central - PubMed

Affiliation: Mycobacteriology Research Centre, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, P.O. Box 19575-154, Tehran 19569-44413, Iran.

ABSTRACT
Nontuberculous mycobacteria (NTM) are opportunistic pathogens that are widely distributed in the environment. There is a lack of data on species distribution of these organisms from Iran. This study consists of a review of NTM articles published in Iran between the years 1992 and 2014. In this review, 20 articles and 14 case reports were identified. Among the 20 articles, 13 (65%) studies focused on NTM isolates from clinical specimens, 6 (30%) studies examined NTM isolates from environmental samples, and one (5%) article included both clinical and environmental isolates. M. fortuitum (229/997; 23%) was recorded as the most prevalent and rapid growing mycobacteria (RGM) species in both clinical (28%) and environmental (19%) isolated samples (P < 0.05). Among slow growing mycobacteria (SGM), M. simiae (103/494; 21%) demonstrated a higher frequency in clinical samples whereas in environmental samples it was M. flavescens (44/503; 9%). These data represent information from 14 provinces out of 31 provinces of Iran. No information is available in current published data on clinical or environmental NTM from the remaining 17 provinces in Iran. These results emphasize the potential importance of NTM as well as the underestimation of NTM frequency in Iran. NTM is an important clinical problem associated with significant morbidity and mortality in Iran. Continued research is needed from both clinical and environmental sources to help clinicians and researchers better understand and address NTM treatment and prevention.

No MeSH data available.


Related in: MedlinePlus

The provinces of Iran which work on NTM in clinical or environmental samples. The most prevalent SGM and RGM were noted.
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fig1: The provinces of Iran which work on NTM in clinical or environmental samples. The most prevalent SGM and RGM were noted.

Mentions: Twenty original articles about NTM isolates were identified. The selected articles were published from 1992 to 2014. The majority of these articles (13/20; 65%) included data from clinical samples, six studies outlined the frequency of NTM in the environment, and a single (5%) article studied both clinical and environmental NTM (Figure 1). The geographical setting of these studies was Tehran in 6 articles (30%), Isfahan in 6 (30%), Khuzestan in 2 (10%), and Golestan in 2 (10%). The remaining articles included provinces such as Sistan and Baluchestan (1/20; 5%), Kerman (1/20; 5%), West Azerbaijan (1/20; 5%), and Gilan (1/20; 5%) (Table 1).


Nontuberculous Mycobacteria Isolation from Clinical and Environmental Samples in Iran: Twenty Years of Surveillance.

Velayati AA, Farnia P, Mozafari M, Mirsaeidi M - Biomed Res Int (2015)

The provinces of Iran which work on NTM in clinical or environmental samples. The most prevalent SGM and RGM were noted.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4477424&req=5

fig1: The provinces of Iran which work on NTM in clinical or environmental samples. The most prevalent SGM and RGM were noted.
Mentions: Twenty original articles about NTM isolates were identified. The selected articles were published from 1992 to 2014. The majority of these articles (13/20; 65%) included data from clinical samples, six studies outlined the frequency of NTM in the environment, and a single (5%) article studied both clinical and environmental NTM (Figure 1). The geographical setting of these studies was Tehran in 6 articles (30%), Isfahan in 6 (30%), Khuzestan in 2 (10%), and Golestan in 2 (10%). The remaining articles included provinces such as Sistan and Baluchestan (1/20; 5%), Kerman (1/20; 5%), West Azerbaijan (1/20; 5%), and Gilan (1/20; 5%) (Table 1).

Bottom Line: These results emphasize the potential importance of NTM as well as the underestimation of NTM frequency in Iran.NTM is an important clinical problem associated with significant morbidity and mortality in Iran.Continued research is needed from both clinical and environmental sources to help clinicians and researchers better understand and address NTM treatment and prevention.

View Article: PubMed Central - PubMed

Affiliation: Mycobacteriology Research Centre, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, P.O. Box 19575-154, Tehran 19569-44413, Iran.

ABSTRACT
Nontuberculous mycobacteria (NTM) are opportunistic pathogens that are widely distributed in the environment. There is a lack of data on species distribution of these organisms from Iran. This study consists of a review of NTM articles published in Iran between the years 1992 and 2014. In this review, 20 articles and 14 case reports were identified. Among the 20 articles, 13 (65%) studies focused on NTM isolates from clinical specimens, 6 (30%) studies examined NTM isolates from environmental samples, and one (5%) article included both clinical and environmental isolates. M. fortuitum (229/997; 23%) was recorded as the most prevalent and rapid growing mycobacteria (RGM) species in both clinical (28%) and environmental (19%) isolated samples (P < 0.05). Among slow growing mycobacteria (SGM), M. simiae (103/494; 21%) demonstrated a higher frequency in clinical samples whereas in environmental samples it was M. flavescens (44/503; 9%). These data represent information from 14 provinces out of 31 provinces of Iran. No information is available in current published data on clinical or environmental NTM from the remaining 17 provinces in Iran. These results emphasize the potential importance of NTM as well as the underestimation of NTM frequency in Iran. NTM is an important clinical problem associated with significant morbidity and mortality in Iran. Continued research is needed from both clinical and environmental sources to help clinicians and researchers better understand and address NTM treatment and prevention.

No MeSH data available.


Related in: MedlinePlus