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Altered baseline brain activity differentiates regional mechanisms subserving biological and psychological alterations in obese men.

Zhang B, Tian D, Yu C, Li M, Zang Y, Liu Y, Walter M - Sci Rep (2015)

Bottom Line: We found that, before food intake, obese men had significantly greater baseline activity in the precuneus and lesser activity in dorsal anterior cingulate cortex (dACC) relative to lean subjects.We further found a significant positive correlation between precuneus activation and hunger ratings before food intake, while dACC activity was negatively correlated with plasma insulin levels before and after food intake.These results indicated that both precuneus and dACC may play an important role in eating behavior.

View Article: PubMed Central - PubMed

Affiliation: 1] Department of Anatomy, Tianjin Medical University, Tianjin, China [2] Department of Psychiatry and Psychotherapy, University of Magdeburg, Magdeburg, Germany [3] Clinical Affective Neuroimaging Laboratory, University of Magdeburg, Magdeburg, Germany [4] Leibniz Institute for Neurobiology, Magdeburg, Germany.

ABSTRACT
Obesity as a chronic disease is a major factor for insulin resistance and Type 2 diabetes, which has become a global health problem. In the present study, we used resting state functional MRI to investigate the amplitude of low frequency fluctuations of spontaneous signal during both hunger and satiety states in 20 lean and 20 obese males. We found that, before food intake, obese men had significantly greater baseline activity in the precuneus and lesser activity in dorsal anterior cingulate cortex (dACC) relative to lean subjects. Furthermore, after food intake, obese males had significantly lesser activity in dACC than lean males. We further found a significant positive correlation between precuneus activation and hunger ratings before food intake, while dACC activity was negatively correlated with plasma insulin levels before and after food intake. These results indicated that both precuneus and dACC may play an important role in eating behavior. While precuneus rather seemed to mediate subjective satiety, dACC levels rather reflected indirect measures of glucose utilization.

No MeSH data available.


Related in: MedlinePlus

Partial correlation adjusted for BMI between the mean activity of precuneus in the pre-meal condition and hunger ratings.
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f3: Partial correlation adjusted for BMI between the mean activity of precuneus in the pre-meal condition and hunger ratings.

Mentions: We then selected regions of interest (ROIs) from these ALFF results (precunes and dACC), and correlated their mean activation levels with plasma insulin and subjective hunger ratings. A positive correlation between precuneus activation and subjects individual rating of hunger, adjusted for BMI, was revealed for conditions before liquid intake (r = 0.372, p < 0.036; Table 2 and Fig. 3). In addition, a significant negative correlation was found between dACC activation and plasma insulin before (r = −0.433, p < 0.005, Table 2 and Fig. 4A) and after liquid intake(r = −0.492, p < 0.001; Table 2 and Fig. 4B). Insulin resistance in terms of HOMA-IR paralleled the negative correlation with dACC ALFF before liquid intake (r = −0.361, p < 0.022), but not after liquid intake (p > 0.1).


Altered baseline brain activity differentiates regional mechanisms subserving biological and psychological alterations in obese men.

Zhang B, Tian D, Yu C, Li M, Zang Y, Liu Y, Walter M - Sci Rep (2015)

Partial correlation adjusted for BMI between the mean activity of precuneus in the pre-meal condition and hunger ratings.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4477369&req=5

f3: Partial correlation adjusted for BMI between the mean activity of precuneus in the pre-meal condition and hunger ratings.
Mentions: We then selected regions of interest (ROIs) from these ALFF results (precunes and dACC), and correlated their mean activation levels with plasma insulin and subjective hunger ratings. A positive correlation between precuneus activation and subjects individual rating of hunger, adjusted for BMI, was revealed for conditions before liquid intake (r = 0.372, p < 0.036; Table 2 and Fig. 3). In addition, a significant negative correlation was found between dACC activation and plasma insulin before (r = −0.433, p < 0.005, Table 2 and Fig. 4A) and after liquid intake(r = −0.492, p < 0.001; Table 2 and Fig. 4B). Insulin resistance in terms of HOMA-IR paralleled the negative correlation with dACC ALFF before liquid intake (r = −0.361, p < 0.022), but not after liquid intake (p > 0.1).

Bottom Line: We found that, before food intake, obese men had significantly greater baseline activity in the precuneus and lesser activity in dorsal anterior cingulate cortex (dACC) relative to lean subjects.We further found a significant positive correlation between precuneus activation and hunger ratings before food intake, while dACC activity was negatively correlated with plasma insulin levels before and after food intake.These results indicated that both precuneus and dACC may play an important role in eating behavior.

View Article: PubMed Central - PubMed

Affiliation: 1] Department of Anatomy, Tianjin Medical University, Tianjin, China [2] Department of Psychiatry and Psychotherapy, University of Magdeburg, Magdeburg, Germany [3] Clinical Affective Neuroimaging Laboratory, University of Magdeburg, Magdeburg, Germany [4] Leibniz Institute for Neurobiology, Magdeburg, Germany.

ABSTRACT
Obesity as a chronic disease is a major factor for insulin resistance and Type 2 diabetes, which has become a global health problem. In the present study, we used resting state functional MRI to investigate the amplitude of low frequency fluctuations of spontaneous signal during both hunger and satiety states in 20 lean and 20 obese males. We found that, before food intake, obese men had significantly greater baseline activity in the precuneus and lesser activity in dorsal anterior cingulate cortex (dACC) relative to lean subjects. Furthermore, after food intake, obese males had significantly lesser activity in dACC than lean males. We further found a significant positive correlation between precuneus activation and hunger ratings before food intake, while dACC activity was negatively correlated with plasma insulin levels before and after food intake. These results indicated that both precuneus and dACC may play an important role in eating behavior. While precuneus rather seemed to mediate subjective satiety, dACC levels rather reflected indirect measures of glucose utilization.

No MeSH data available.


Related in: MedlinePlus