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Altered baseline brain activity differentiates regional mechanisms subserving biological and psychological alterations in obese men.

Zhang B, Tian D, Yu C, Li M, Zang Y, Liu Y, Walter M - Sci Rep (2015)

Bottom Line: We found that, before food intake, obese men had significantly greater baseline activity in the precuneus and lesser activity in dorsal anterior cingulate cortex (dACC) relative to lean subjects.We further found a significant positive correlation between precuneus activation and hunger ratings before food intake, while dACC activity was negatively correlated with plasma insulin levels before and after food intake.These results indicated that both precuneus and dACC may play an important role in eating behavior.

View Article: PubMed Central - PubMed

Affiliation: 1] Department of Anatomy, Tianjin Medical University, Tianjin, China [2] Department of Psychiatry and Psychotherapy, University of Magdeburg, Magdeburg, Germany [3] Clinical Affective Neuroimaging Laboratory, University of Magdeburg, Magdeburg, Germany [4] Leibniz Institute for Neurobiology, Magdeburg, Germany.

ABSTRACT
Obesity as a chronic disease is a major factor for insulin resistance and Type 2 diabetes, which has become a global health problem. In the present study, we used resting state functional MRI to investigate the amplitude of low frequency fluctuations of spontaneous signal during both hunger and satiety states in 20 lean and 20 obese males. We found that, before food intake, obese men had significantly greater baseline activity in the precuneus and lesser activity in dorsal anterior cingulate cortex (dACC) relative to lean subjects. Furthermore, after food intake, obese males had significantly lesser activity in dACC than lean males. We further found a significant positive correlation between precuneus activation and hunger ratings before food intake, while dACC activity was negatively correlated with plasma insulin levels before and after food intake. These results indicated that both precuneus and dACC may play an important role in eating behavior. While precuneus rather seemed to mediate subjective satiety, dACC levels rather reflected indirect measures of glucose utilization.

No MeSH data available.


Related in: MedlinePlus

A T-statistic map showed the ALFF differences before liquid intake between obese subjects and controls (p < 0.05, corrected).Hot and cold colors indicate greater and lower ALFF activity in obese subject relative to healthy controls, respectively.
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f1: A T-statistic map showed the ALFF differences before liquid intake between obese subjects and controls (p < 0.05, corrected).Hot and cold colors indicate greater and lower ALFF activity in obese subject relative to healthy controls, respectively.

Mentions: Before liquid intake, obese male subjects, compared to the lean control group, had significantly greater resting state activity in the bilateral precuneus (Fig. 1, p-value < 0.05, corrected; right precuneus: x = 9, y = −66, z = 60, k = 153; left precuneus: x = −12, y = −60, z = 66, k = 62) and significantly lower resting state activity in the dorsal anterior cingulate cortex (dACC) (Fig. 1, p-value < 0.05, corrected, x = 15, y = 24, z = 18, k = 150). After liquid intake, only the lower activity in the dACC (Fig. 2, p-value < 0.05, corrected, x = −6, y = 9, z = 24, k = 49) compared to the control group, however no increased activity in the precuneus was not observed.


Altered baseline brain activity differentiates regional mechanisms subserving biological and psychological alterations in obese men.

Zhang B, Tian D, Yu C, Li M, Zang Y, Liu Y, Walter M - Sci Rep (2015)

A T-statistic map showed the ALFF differences before liquid intake between obese subjects and controls (p < 0.05, corrected).Hot and cold colors indicate greater and lower ALFF activity in obese subject relative to healthy controls, respectively.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4477369&req=5

f1: A T-statistic map showed the ALFF differences before liquid intake between obese subjects and controls (p < 0.05, corrected).Hot and cold colors indicate greater and lower ALFF activity in obese subject relative to healthy controls, respectively.
Mentions: Before liquid intake, obese male subjects, compared to the lean control group, had significantly greater resting state activity in the bilateral precuneus (Fig. 1, p-value < 0.05, corrected; right precuneus: x = 9, y = −66, z = 60, k = 153; left precuneus: x = −12, y = −60, z = 66, k = 62) and significantly lower resting state activity in the dorsal anterior cingulate cortex (dACC) (Fig. 1, p-value < 0.05, corrected, x = 15, y = 24, z = 18, k = 150). After liquid intake, only the lower activity in the dACC (Fig. 2, p-value < 0.05, corrected, x = −6, y = 9, z = 24, k = 49) compared to the control group, however no increased activity in the precuneus was not observed.

Bottom Line: We found that, before food intake, obese men had significantly greater baseline activity in the precuneus and lesser activity in dorsal anterior cingulate cortex (dACC) relative to lean subjects.We further found a significant positive correlation between precuneus activation and hunger ratings before food intake, while dACC activity was negatively correlated with plasma insulin levels before and after food intake.These results indicated that both precuneus and dACC may play an important role in eating behavior.

View Article: PubMed Central - PubMed

Affiliation: 1] Department of Anatomy, Tianjin Medical University, Tianjin, China [2] Department of Psychiatry and Psychotherapy, University of Magdeburg, Magdeburg, Germany [3] Clinical Affective Neuroimaging Laboratory, University of Magdeburg, Magdeburg, Germany [4] Leibniz Institute for Neurobiology, Magdeburg, Germany.

ABSTRACT
Obesity as a chronic disease is a major factor for insulin resistance and Type 2 diabetes, which has become a global health problem. In the present study, we used resting state functional MRI to investigate the amplitude of low frequency fluctuations of spontaneous signal during both hunger and satiety states in 20 lean and 20 obese males. We found that, before food intake, obese men had significantly greater baseline activity in the precuneus and lesser activity in dorsal anterior cingulate cortex (dACC) relative to lean subjects. Furthermore, after food intake, obese males had significantly lesser activity in dACC than lean males. We further found a significant positive correlation between precuneus activation and hunger ratings before food intake, while dACC activity was negatively correlated with plasma insulin levels before and after food intake. These results indicated that both precuneus and dACC may play an important role in eating behavior. While precuneus rather seemed to mediate subjective satiety, dACC levels rather reflected indirect measures of glucose utilization.

No MeSH data available.


Related in: MedlinePlus