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Improvement of antioxidant status after Brazil nut intake in hypertensive and dyslipidemic subjects.

Huguenin GV, Oliveira GM, Moreira AS, Saint'Pierre TD, Gonçalves RA, Pinheiro-Mulder AR, Teodoro AJ, Luiz RR, Rosa G - Nutr J (2015)

Bottom Line: GBN intake significantly increased plasma Se from 87.0 ± 16.8 to 180.6 ± 67.1 μg/L, increased GPx3 activity in 24,8% (from 112.66 ± 40.09 to 128.32 ± 38.31 nmol/min/mL, p < 0,05), and reduced 3.25% of oxidized-LDL levels (from 66.31 ± 23.59 to 60.68 ± 20.88 U/L, p < 0.05).There wasn't association between GPx3 and 8-epi PGF2α (β -0.209, p = 0.052) by simple model.The partially defatted GBN intake has a potential benefit to increase plasma selenium, increase enzymatic antioxidant activity of GPx3 and to reduction oxidation in LDL in hypertensive and dyslipidemic patients.

View Article: PubMed Central - PubMed

Affiliation: Institute of Heart Edson Saad, Federal Universityof Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil. grazielle.huguenin@gmail.com.

ABSTRACT

Objectives: To investigate the effect of partially defatted Granulated Brazil nut (GBN) on biomarkers of oxidative stress and antioxidant status of hypertensive and dyslipidemic patients on nutrition and drug approaches.

Methods: Ninety one hypertensive and dyslipidemic subjects of both genders (51.6 % men), mean age 62.1 ± 9.3 years, performed a randomized crossover trial, double-blind, placebo controlled. Subjects received a diet and partially defatted GBN 13 g per day (≈227.5 μg/day of selenium) or placebo for twelve weeks with four-week washout interval. Anthropometric, laboratory and clinic characteristics were investigated at baseline. Plasma selenium (Se), plasma glutathione peroxidase (GPx3) activity, total antioxidant capacity (TAC), 8-epi PGF2α and oxidized LDL were evaluated at the beginning and in the end of each intervention.

Results: GBN intake significantly increased plasma Se from 87.0 ± 16.8 to 180.6 ± 67.1 μg/L, increased GPx3 activity in 24,8% (from 112.66 ± 40.09 to 128.32 ± 38.31 nmol/min/mL, p < 0,05), and reduced 3.25% of oxidized-LDL levels (from 66.31 ± 23.59 to 60.68 ± 20.88 U/L, p < 0.05). An inverse association between GPx3 and oxidized LDL levels was observed after supplementation with GBN by simple model (β -0.232, p = 0.032) and after adjustment for gender, age, diabetes and BMI (β -0.298, p = 0.008). There wasn't association between GPx3 and 8-epi PGF2α (β -0.209, p = 0.052) by simple model.

Conclusion: The partially defatted GBN intake has a potential benefit to increase plasma selenium, increase enzymatic antioxidant activity of GPx3 and to reduction oxidation in LDL in hypertensive and dyslipidemic patients.

Trial registration: ClinicalTrials.gov Identifier NCT01990391; November 20, 2013.

No MeSH data available.


Related in: MedlinePlus

Changes at 12 weeks in the markers of antioxidant status and oxidative stress. # p < 0.05. Student’s t-test (a, b, c, d). GPx3: plasma glutathione peroxidase; TAC: total antioxidant capacity of plasma; 8-epi PGF2α: 8-epi prostaglandin F2α; LDL: low density lipoprotein
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Fig3: Changes at 12 weeks in the markers of antioxidant status and oxidative stress. # p < 0.05. Student’s t-test (a, b, c, d). GPx3: plasma glutathione peroxidase; TAC: total antioxidant capacity of plasma; 8-epi PGF2α: 8-epi prostaglandin F2α; LDL: low density lipoprotein

Mentions: The oxidative stress markers variation percentage and antioxidant capacity according to dietary intervention at the end of the study is presented in Fig. 3. It was observed increase in GPx3 activity by 24.8 % in Granulated Brazil Nut and it was statistical different from placebo (p = 0.034), an oxidized-LDL reduction by 3.2 % after Granulated Brazil Nut intervention but it was no statistical different from placebo. There were no statistical difference between Granulated Brazil Nut and placebo for plasma total antioxidant capacity and 8-epi PGF2α (Fig. 3).Fig. 3


Improvement of antioxidant status after Brazil nut intake in hypertensive and dyslipidemic subjects.

Huguenin GV, Oliveira GM, Moreira AS, Saint'Pierre TD, Gonçalves RA, Pinheiro-Mulder AR, Teodoro AJ, Luiz RR, Rosa G - Nutr J (2015)

Changes at 12 weeks in the markers of antioxidant status and oxidative stress. # p < 0.05. Student’s t-test (a, b, c, d). GPx3: plasma glutathione peroxidase; TAC: total antioxidant capacity of plasma; 8-epi PGF2α: 8-epi prostaglandin F2α; LDL: low density lipoprotein
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4477321&req=5

Fig3: Changes at 12 weeks in the markers of antioxidant status and oxidative stress. # p < 0.05. Student’s t-test (a, b, c, d). GPx3: plasma glutathione peroxidase; TAC: total antioxidant capacity of plasma; 8-epi PGF2α: 8-epi prostaglandin F2α; LDL: low density lipoprotein
Mentions: The oxidative stress markers variation percentage and antioxidant capacity according to dietary intervention at the end of the study is presented in Fig. 3. It was observed increase in GPx3 activity by 24.8 % in Granulated Brazil Nut and it was statistical different from placebo (p = 0.034), an oxidized-LDL reduction by 3.2 % after Granulated Brazil Nut intervention but it was no statistical different from placebo. There were no statistical difference between Granulated Brazil Nut and placebo for plasma total antioxidant capacity and 8-epi PGF2α (Fig. 3).Fig. 3

Bottom Line: GBN intake significantly increased plasma Se from 87.0 ± 16.8 to 180.6 ± 67.1 μg/L, increased GPx3 activity in 24,8% (from 112.66 ± 40.09 to 128.32 ± 38.31 nmol/min/mL, p < 0,05), and reduced 3.25% of oxidized-LDL levels (from 66.31 ± 23.59 to 60.68 ± 20.88 U/L, p < 0.05).There wasn't association between GPx3 and 8-epi PGF2α (β -0.209, p = 0.052) by simple model.The partially defatted GBN intake has a potential benefit to increase plasma selenium, increase enzymatic antioxidant activity of GPx3 and to reduction oxidation in LDL in hypertensive and dyslipidemic patients.

View Article: PubMed Central - PubMed

Affiliation: Institute of Heart Edson Saad, Federal Universityof Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil. grazielle.huguenin@gmail.com.

ABSTRACT

Objectives: To investigate the effect of partially defatted Granulated Brazil nut (GBN) on biomarkers of oxidative stress and antioxidant status of hypertensive and dyslipidemic patients on nutrition and drug approaches.

Methods: Ninety one hypertensive and dyslipidemic subjects of both genders (51.6 % men), mean age 62.1 ± 9.3 years, performed a randomized crossover trial, double-blind, placebo controlled. Subjects received a diet and partially defatted GBN 13 g per day (≈227.5 μg/day of selenium) or placebo for twelve weeks with four-week washout interval. Anthropometric, laboratory and clinic characteristics were investigated at baseline. Plasma selenium (Se), plasma glutathione peroxidase (GPx3) activity, total antioxidant capacity (TAC), 8-epi PGF2α and oxidized LDL were evaluated at the beginning and in the end of each intervention.

Results: GBN intake significantly increased plasma Se from 87.0 ± 16.8 to 180.6 ± 67.1 μg/L, increased GPx3 activity in 24,8% (from 112.66 ± 40.09 to 128.32 ± 38.31 nmol/min/mL, p < 0,05), and reduced 3.25% of oxidized-LDL levels (from 66.31 ± 23.59 to 60.68 ± 20.88 U/L, p < 0.05). An inverse association between GPx3 and oxidized LDL levels was observed after supplementation with GBN by simple model (β -0.232, p = 0.032) and after adjustment for gender, age, diabetes and BMI (β -0.298, p = 0.008). There wasn't association between GPx3 and 8-epi PGF2α (β -0.209, p = 0.052) by simple model.

Conclusion: The partially defatted GBN intake has a potential benefit to increase plasma selenium, increase enzymatic antioxidant activity of GPx3 and to reduction oxidation in LDL in hypertensive and dyslipidemic patients.

Trial registration: ClinicalTrials.gov Identifier NCT01990391; November 20, 2013.

No MeSH data available.


Related in: MedlinePlus