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Hepatolithiasis associated with intrahepatic heterotopic pancreas: a case report and literature review.

Yu ZY, Sun ZQ, Zhang M, Wang B, Lu W, Zheng SS - Diagn Pathol (2015)

Bottom Line: Here, we report a case of a 39-year-old male with intrahepatic heterotopic pancreas associated with primary cholesterol hepatolithiasis.These observations were confirmed by magnetic resonance cholangiopaneretography (MRCP).Postoperative histological examination of the resected specimen showed pancreatic tissues distributed along the wall of the bile duct and composed of acinar cells and duct elements without islets of Langerhans, therefore strongly suggesting that the heterotopic pancreas occurred in response to chronic injury due to the primary cholesterol hepatolithiasis and was derived from the biliary epithelial cells.

View Article: PubMed Central - PubMed

Affiliation: Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejing University School of Medicine, Hangzhou, 310003, Zhejing Province, China. purprain@163.com.

ABSTRACT

Unlabelled: Intrahepatic heterotopic pancreas is rarely reported in the literature. Here, we report a case of a 39-year-old male with intrahepatic heterotopic pancreas associated with primary cholesterol hepatolithiasis. Computed tomography (CT) scans revealed multiple cholesterol stones in intrahepatic bile ducts of the left lobe concomitant with intrahepatic cholangiectases. These observations were confirmed by magnetic resonance cholangiopaneretography (MRCP). The patient underwent transabdominal left hepatic lobectomy. Postoperative histological examination of the resected specimen showed pancreatic tissues distributed along the wall of the bile duct and composed of acinar cells and duct elements without islets of Langerhans, therefore strongly suggesting that the heterotopic pancreas occurred in response to chronic injury due to the primary cholesterol hepatolithiasis and was derived from the biliary epithelial cells.

Virtual slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1461819267158980 .

No MeSH data available.


Related in: MedlinePlus

Histological examination showed pancreatic tissues distributed along the wall of the bile duct. a: The pancreatic tissues consisted of acinar cells and duct elements [hematoxylin and eosin (HE), ×4]; b: The acinar cells contained eosinophilic granules (HE, ×20)
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Fig2: Histological examination showed pancreatic tissues distributed along the wall of the bile duct. a: The pancreatic tissues consisted of acinar cells and duct elements [hematoxylin and eosin (HE), ×4]; b: The acinar cells contained eosinophilic granules (HE, ×20)

Mentions: Gross examination showed a few yellowish-white biliary calculi within the left hepatic lobe and distinct strictures of several biliary tracts. The dilated bile ducts had a maximum circumference of 1.2 cm. Histological examination of the resected specimen showed pancreatic tissues distributed along the wall of the bile duct and composed of acinar cells and duct elements without islets of Langerhans (Fig. 2a). The acinar cells contained eosinophilic granules (Fig. 2b). The pathological diagnosis was intrahepatic cholangiectases with hepatolithiasis concomitant with pancreatic heterotopia.Fig. 2


Hepatolithiasis associated with intrahepatic heterotopic pancreas: a case report and literature review.

Yu ZY, Sun ZQ, Zhang M, Wang B, Lu W, Zheng SS - Diagn Pathol (2015)

Histological examination showed pancreatic tissues distributed along the wall of the bile duct. a: The pancreatic tissues consisted of acinar cells and duct elements [hematoxylin and eosin (HE), ×4]; b: The acinar cells contained eosinophilic granules (HE, ×20)
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4477297&req=5

Fig2: Histological examination showed pancreatic tissues distributed along the wall of the bile duct. a: The pancreatic tissues consisted of acinar cells and duct elements [hematoxylin and eosin (HE), ×4]; b: The acinar cells contained eosinophilic granules (HE, ×20)
Mentions: Gross examination showed a few yellowish-white biliary calculi within the left hepatic lobe and distinct strictures of several biliary tracts. The dilated bile ducts had a maximum circumference of 1.2 cm. Histological examination of the resected specimen showed pancreatic tissues distributed along the wall of the bile duct and composed of acinar cells and duct elements without islets of Langerhans (Fig. 2a). The acinar cells contained eosinophilic granules (Fig. 2b). The pathological diagnosis was intrahepatic cholangiectases with hepatolithiasis concomitant with pancreatic heterotopia.Fig. 2

Bottom Line: Here, we report a case of a 39-year-old male with intrahepatic heterotopic pancreas associated with primary cholesterol hepatolithiasis.These observations were confirmed by magnetic resonance cholangiopaneretography (MRCP).Postoperative histological examination of the resected specimen showed pancreatic tissues distributed along the wall of the bile duct and composed of acinar cells and duct elements without islets of Langerhans, therefore strongly suggesting that the heterotopic pancreas occurred in response to chronic injury due to the primary cholesterol hepatolithiasis and was derived from the biliary epithelial cells.

View Article: PubMed Central - PubMed

Affiliation: Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejing University School of Medicine, Hangzhou, 310003, Zhejing Province, China. purprain@163.com.

ABSTRACT

Unlabelled: Intrahepatic heterotopic pancreas is rarely reported in the literature. Here, we report a case of a 39-year-old male with intrahepatic heterotopic pancreas associated with primary cholesterol hepatolithiasis. Computed tomography (CT) scans revealed multiple cholesterol stones in intrahepatic bile ducts of the left lobe concomitant with intrahepatic cholangiectases. These observations were confirmed by magnetic resonance cholangiopaneretography (MRCP). The patient underwent transabdominal left hepatic lobectomy. Postoperative histological examination of the resected specimen showed pancreatic tissues distributed along the wall of the bile duct and composed of acinar cells and duct elements without islets of Langerhans, therefore strongly suggesting that the heterotopic pancreas occurred in response to chronic injury due to the primary cholesterol hepatolithiasis and was derived from the biliary epithelial cells.

Virtual slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1461819267158980 .

No MeSH data available.


Related in: MedlinePlus