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Tiliacora triandra, an Anti-Intoxication Plant, Improves Memory Impairment, Neurodegeneration, Cholinergic Function, and Oxidative Stress in Hippocampus of Ethanol Dependence Rats.

Phunchago N, Wattanathorn J, Chaisiwamongkol K - Oxid Med Cell Longev (2015)

Bottom Line: The extract also mitigated the decreased retention time, SOD, CAT, and GSH-Px activities, and neurons density in hippocampus induced by alcohol.Therefore, T. triandra is the potential reagent for treating brain dysfunction induced by alcohol.However, further researches are necessary to understand the detail mechanism and possible active ingredient.

View Article: PubMed Central - PubMed

Affiliation: Department of Physiology (Neuroscience Program) and Graduate School, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand ; Integrative Complementary Alternative Medicine Research and Development Center, Khon Kaen University, Khon Kaen 40002, Thailand.

ABSTRACT
Oxidative stress plays an important role in brain dysfunctions induced by alcohol. Since less therapeutic agent against cognitive deficit and brain damage induced by chronic alcohol consumption is less available, we aimed to assess the effect of Tiliacora triandra extract, a plant possessing antioxidant activity, on memory impairment, neuron density, cholinergic function, and oxidative stress in hippocampus of alcoholic rats. Male Wistar rats were induced ethanol dependence condition by semivoluntary intake of alcohol for 15 weeks. Alcoholic rats were orally given T. triandra at doses of 100, 200, and 400 mg·kg(-1)BW for 14 days. Memory assessment was performed every 7 days while neuron density, activities of AChE, SOD, CAT, and GSH-Px and, MDA level in hippocampus were assessed at the end of study. Interestingly, the extract mitigated the increased escape latency, AChE and MDA level. The extract also mitigated the decreased retention time, SOD, CAT, and GSH-Px activities, and neurons density in hippocampus induced by alcohol. These data suggested that the extract improved memory deficit in alcoholic rats partly via the decreased oxidative stress and the suppression of AChE. Therefore, T. triandra is the potential reagent for treating brain dysfunction induced by alcohol. However, further researches are necessary to understand the detail mechanism and possible active ingredient.

No MeSH data available.


Related in: MedlinePlus

The effect of T. triandra on the activity of acetylcholinesterase (AChE) in hippocampus. Data were presented as mean ± SEM, n = 6/group ###P value < 0.001 compared with control treated group. ∗∗P value < 0.01 compared with ethanol dependence treated group which received vehicle. ∗∗∗P value < 0.001 compared with ethanol dependence treated group which received vehicle.
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fig4: The effect of T. triandra on the activity of acetylcholinesterase (AChE) in hippocampus. Data were presented as mean ± SEM, n = 6/group ###P value < 0.001 compared with control treated group. ∗∗P value < 0.01 compared with ethanol dependence treated group which received vehicle. ∗∗∗P value < 0.001 compared with ethanol dependence treated group which received vehicle.

Mentions: Since cholinergic system played an important role on spatial memory, we also investigated the effect of T. triandra on AChE activity in this area. The results were shown in Figure 4. The significant elevation of AChE activity in hippocampus was observed in ethanol dependence rats which received vehicle (P value < 0.001, compared with control rats). Treatment with either donepezil or vitamin C could mitigate the elevation of AChE in hippocampus (P value < 0.01 all, compared with ethanol dependence rats which received vehicle). Ethanol dependence rats which received the extract at dose of 200 mg·kg−1BW also significantly mitigated an elevation of AChE activity induced by ethanol consumption in hippocampus (P value < 0.01 all, compared with ethanol dependence rats which received vehicle) while no changes were observed in ethanol dependence rats which received low and high doses of extract.


Tiliacora triandra, an Anti-Intoxication Plant, Improves Memory Impairment, Neurodegeneration, Cholinergic Function, and Oxidative Stress in Hippocampus of Ethanol Dependence Rats.

Phunchago N, Wattanathorn J, Chaisiwamongkol K - Oxid Med Cell Longev (2015)

The effect of T. triandra on the activity of acetylcholinesterase (AChE) in hippocampus. Data were presented as mean ± SEM, n = 6/group ###P value < 0.001 compared with control treated group. ∗∗P value < 0.01 compared with ethanol dependence treated group which received vehicle. ∗∗∗P value < 0.001 compared with ethanol dependence treated group which received vehicle.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4477251&req=5

fig4: The effect of T. triandra on the activity of acetylcholinesterase (AChE) in hippocampus. Data were presented as mean ± SEM, n = 6/group ###P value < 0.001 compared with control treated group. ∗∗P value < 0.01 compared with ethanol dependence treated group which received vehicle. ∗∗∗P value < 0.001 compared with ethanol dependence treated group which received vehicle.
Mentions: Since cholinergic system played an important role on spatial memory, we also investigated the effect of T. triandra on AChE activity in this area. The results were shown in Figure 4. The significant elevation of AChE activity in hippocampus was observed in ethanol dependence rats which received vehicle (P value < 0.001, compared with control rats). Treatment with either donepezil or vitamin C could mitigate the elevation of AChE in hippocampus (P value < 0.01 all, compared with ethanol dependence rats which received vehicle). Ethanol dependence rats which received the extract at dose of 200 mg·kg−1BW also significantly mitigated an elevation of AChE activity induced by ethanol consumption in hippocampus (P value < 0.01 all, compared with ethanol dependence rats which received vehicle) while no changes were observed in ethanol dependence rats which received low and high doses of extract.

Bottom Line: The extract also mitigated the decreased retention time, SOD, CAT, and GSH-Px activities, and neurons density in hippocampus induced by alcohol.Therefore, T. triandra is the potential reagent for treating brain dysfunction induced by alcohol.However, further researches are necessary to understand the detail mechanism and possible active ingredient.

View Article: PubMed Central - PubMed

Affiliation: Department of Physiology (Neuroscience Program) and Graduate School, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand ; Integrative Complementary Alternative Medicine Research and Development Center, Khon Kaen University, Khon Kaen 40002, Thailand.

ABSTRACT
Oxidative stress plays an important role in brain dysfunctions induced by alcohol. Since less therapeutic agent against cognitive deficit and brain damage induced by chronic alcohol consumption is less available, we aimed to assess the effect of Tiliacora triandra extract, a plant possessing antioxidant activity, on memory impairment, neuron density, cholinergic function, and oxidative stress in hippocampus of alcoholic rats. Male Wistar rats were induced ethanol dependence condition by semivoluntary intake of alcohol for 15 weeks. Alcoholic rats were orally given T. triandra at doses of 100, 200, and 400 mg·kg(-1)BW for 14 days. Memory assessment was performed every 7 days while neuron density, activities of AChE, SOD, CAT, and GSH-Px and, MDA level in hippocampus were assessed at the end of study. Interestingly, the extract mitigated the increased escape latency, AChE and MDA level. The extract also mitigated the decreased retention time, SOD, CAT, and GSH-Px activities, and neurons density in hippocampus induced by alcohol. These data suggested that the extract improved memory deficit in alcoholic rats partly via the decreased oxidative stress and the suppression of AChE. Therefore, T. triandra is the potential reagent for treating brain dysfunction induced by alcohol. However, further researches are necessary to understand the detail mechanism and possible active ingredient.

No MeSH data available.


Related in: MedlinePlus