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Tiliacora triandra, an Anti-Intoxication Plant, Improves Memory Impairment, Neurodegeneration, Cholinergic Function, and Oxidative Stress in Hippocampus of Ethanol Dependence Rats.

Phunchago N, Wattanathorn J, Chaisiwamongkol K - Oxid Med Cell Longev (2015)

Bottom Line: The extract also mitigated the decreased retention time, SOD, CAT, and GSH-Px activities, and neurons density in hippocampus induced by alcohol.Therefore, T. triandra is the potential reagent for treating brain dysfunction induced by alcohol.However, further researches are necessary to understand the detail mechanism and possible active ingredient.

View Article: PubMed Central - PubMed

Affiliation: Department of Physiology (Neuroscience Program) and Graduate School, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand ; Integrative Complementary Alternative Medicine Research and Development Center, Khon Kaen University, Khon Kaen 40002, Thailand.

ABSTRACT
Oxidative stress plays an important role in brain dysfunctions induced by alcohol. Since less therapeutic agent against cognitive deficit and brain damage induced by chronic alcohol consumption is less available, we aimed to assess the effect of Tiliacora triandra extract, a plant possessing antioxidant activity, on memory impairment, neuron density, cholinergic function, and oxidative stress in hippocampus of alcoholic rats. Male Wistar rats were induced ethanol dependence condition by semivoluntary intake of alcohol for 15 weeks. Alcoholic rats were orally given T. triandra at doses of 100, 200, and 400 mg·kg(-1)BW for 14 days. Memory assessment was performed every 7 days while neuron density, activities of AChE, SOD, CAT, and GSH-Px and, MDA level in hippocampus were assessed at the end of study. Interestingly, the extract mitigated the increased escape latency, AChE and MDA level. The extract also mitigated the decreased retention time, SOD, CAT, and GSH-Px activities, and neurons density in hippocampus induced by alcohol. These data suggested that the extract improved memory deficit in alcoholic rats partly via the decreased oxidative stress and the suppression of AChE. Therefore, T. triandra is the potential reagent for treating brain dysfunction induced by alcohol. However, further researches are necessary to understand the detail mechanism and possible active ingredient.

No MeSH data available.


Related in: MedlinePlus

The effect of T. triandra on retention time in Morris water maze test. Data were presented as mean ± SEM, n = 6/group. ###P value < 0.001 compared with control treated group. ∗P value < 0.05 compared with ethanol dependence treated group which received vehicle. ∗∗∗P value < 0.001 compared with ethanol dependence treated group which received vehicle.
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fig3: The effect of T. triandra on retention time in Morris water maze test. Data were presented as mean ± SEM, n = 6/group. ###P value < 0.001 compared with control treated group. ∗P value < 0.05 compared with ethanol dependence treated group which received vehicle. ∗∗∗P value < 0.001 compared with ethanol dependence treated group which received vehicle.

Mentions: The effect of T. triandra on retention time in Morris water maze test was also investigated and results were shown in Figure 3. It was found that ethanol dependence rats which received vehicle showed the decreased retention time throughout the 14-day study period (P value < 0.001 all, compared to control rats). Ethanol dependence rats which received either donepezil or vitamin C significantly mitigated the decreased retention time induced by alcohol consumption at 7 and 14 days of treatment (P value < 0.001 all, compared with ethanol dependence rats which received vehicle). In addition, ethanol dependence rats which received T. triandra at doses of 200 and 400 mg·kg−1BW also showed the significant attenuation of the decreased retention time induced by ethanol consumption both at 7 (P value < 0.001 and 0.05, resp., compared with ethanol dependence rats which received vehicle) and 14 days of treatments (P value < 0.001 all, compared with ethanol dependence rats which received vehicle). However, ethanol dependence rats which received T. triandra at dose of 100 mg·kg−1BW significantly attenuated the decreased retention time induced by ethanol consumption only at 14 days of treatment (P value < 0.05, compared with ethanol dependence rats which received vehicle).


Tiliacora triandra, an Anti-Intoxication Plant, Improves Memory Impairment, Neurodegeneration, Cholinergic Function, and Oxidative Stress in Hippocampus of Ethanol Dependence Rats.

Phunchago N, Wattanathorn J, Chaisiwamongkol K - Oxid Med Cell Longev (2015)

The effect of T. triandra on retention time in Morris water maze test. Data were presented as mean ± SEM, n = 6/group. ###P value < 0.001 compared with control treated group. ∗P value < 0.05 compared with ethanol dependence treated group which received vehicle. ∗∗∗P value < 0.001 compared with ethanol dependence treated group which received vehicle.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4477251&req=5

fig3: The effect of T. triandra on retention time in Morris water maze test. Data were presented as mean ± SEM, n = 6/group. ###P value < 0.001 compared with control treated group. ∗P value < 0.05 compared with ethanol dependence treated group which received vehicle. ∗∗∗P value < 0.001 compared with ethanol dependence treated group which received vehicle.
Mentions: The effect of T. triandra on retention time in Morris water maze test was also investigated and results were shown in Figure 3. It was found that ethanol dependence rats which received vehicle showed the decreased retention time throughout the 14-day study period (P value < 0.001 all, compared to control rats). Ethanol dependence rats which received either donepezil or vitamin C significantly mitigated the decreased retention time induced by alcohol consumption at 7 and 14 days of treatment (P value < 0.001 all, compared with ethanol dependence rats which received vehicle). In addition, ethanol dependence rats which received T. triandra at doses of 200 and 400 mg·kg−1BW also showed the significant attenuation of the decreased retention time induced by ethanol consumption both at 7 (P value < 0.001 and 0.05, resp., compared with ethanol dependence rats which received vehicle) and 14 days of treatments (P value < 0.001 all, compared with ethanol dependence rats which received vehicle). However, ethanol dependence rats which received T. triandra at dose of 100 mg·kg−1BW significantly attenuated the decreased retention time induced by ethanol consumption only at 14 days of treatment (P value < 0.05, compared with ethanol dependence rats which received vehicle).

Bottom Line: The extract also mitigated the decreased retention time, SOD, CAT, and GSH-Px activities, and neurons density in hippocampus induced by alcohol.Therefore, T. triandra is the potential reagent for treating brain dysfunction induced by alcohol.However, further researches are necessary to understand the detail mechanism and possible active ingredient.

View Article: PubMed Central - PubMed

Affiliation: Department of Physiology (Neuroscience Program) and Graduate School, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand ; Integrative Complementary Alternative Medicine Research and Development Center, Khon Kaen University, Khon Kaen 40002, Thailand.

ABSTRACT
Oxidative stress plays an important role in brain dysfunctions induced by alcohol. Since less therapeutic agent against cognitive deficit and brain damage induced by chronic alcohol consumption is less available, we aimed to assess the effect of Tiliacora triandra extract, a plant possessing antioxidant activity, on memory impairment, neuron density, cholinergic function, and oxidative stress in hippocampus of alcoholic rats. Male Wistar rats were induced ethanol dependence condition by semivoluntary intake of alcohol for 15 weeks. Alcoholic rats were orally given T. triandra at doses of 100, 200, and 400 mg·kg(-1)BW for 14 days. Memory assessment was performed every 7 days while neuron density, activities of AChE, SOD, CAT, and GSH-Px and, MDA level in hippocampus were assessed at the end of study. Interestingly, the extract mitigated the increased escape latency, AChE and MDA level. The extract also mitigated the decreased retention time, SOD, CAT, and GSH-Px activities, and neurons density in hippocampus induced by alcohol. These data suggested that the extract improved memory deficit in alcoholic rats partly via the decreased oxidative stress and the suppression of AChE. Therefore, T. triandra is the potential reagent for treating brain dysfunction induced by alcohol. However, further researches are necessary to understand the detail mechanism and possible active ingredient.

No MeSH data available.


Related in: MedlinePlus