Limits...
An Organ System Approach to Explore the Antioxidative, Anti-Inflammatory, and Cytoprotective Actions of Resveratrol.

Malhotra A, Bath S, Elbarbry F - Oxid Med Cell Longev (2015)

Bottom Line: It is a bioactive molecule with physiological effects on multiple organ systems.Its effects range from the neuroprotective to the nephroprotective, including cardiovascular, neuronal, and antineoplastic responses as a part of its broad spectrum of action.We summarize the known anti-inflammatory, antioxidative, and cytoprotective effects of resveratrol across disparate organ systems.

View Article: PubMed Central - PubMed

Affiliation: School of Pharmacy, Pacific University, 222 SE 8th Avenue, Suite 451, Hillsboro, OR 97123, USA.

ABSTRACT
Resveratrol is a phenolic phytochemical, with a stilbene backbone, derived from edible plants such as grape and peanut. It is a bioactive molecule with physiological effects on multiple organ systems. Its effects range from the neuroprotective to the nephroprotective, including cardiovascular, neuronal, and antineoplastic responses as a part of its broad spectrum of action. In this review, we examine the effects of resveratrol on the following organ systems: the central nervous system, including neurological pathology such as Parkinson's and Alzheimer's disease; the cardiovascular system, including disorders such as atherosclerosis, ischemia-reperfusion injury, and cardiomyocyte hypertrophy; the kidneys, including primary and secondary nephropathies and nephrolithiasis; multiple forms of cancer; and metabolic syndromes including diabetes. We emphasize commonalities in extracellular matrix protein alterations and intracellular signal transduction system induction following resveratrol treatment. We summarize the known anti-inflammatory, antioxidative, and cytoprotective effects of resveratrol across disparate organ systems. Additionally, we analyze the available literature regarding the pharmacokinetics of resveratrol formulations used in these studies. Finally, we critically examine select clinical trials documenting a lack of effect following resveratrol treatment.

No MeSH data available.


Related in: MedlinePlus

A summary of the published health benefits of resveratrol with the potential underlying molecular mechanisms. (See the Abbreviations section for complete definition of the abbreviations.)
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4477248&req=5

fig2: A summary of the published health benefits of resveratrol with the potential underlying molecular mechanisms. (See the Abbreviations section for complete definition of the abbreviations.)

Mentions: In brief, plethora of reports from in vitro and laboratory animal studies in the past decade has suggested that resveratrol has considerable potential for therapy and/or protection for numerous acute and chronic diseases. These data were supported, in most part, by the emerging results from limited human clinical trials. Larger controlled human clinical trials are still needed to investigate dose- and formulation-dependent efficacy and safety of resveratrol and to study the effect of long-term effect of resveratrol supplementation. Figure 2 provides a summary of the aforementioned health benefits of resveratrol with potential underlying molecular mechanisms.


An Organ System Approach to Explore the Antioxidative, Anti-Inflammatory, and Cytoprotective Actions of Resveratrol.

Malhotra A, Bath S, Elbarbry F - Oxid Med Cell Longev (2015)

A summary of the published health benefits of resveratrol with the potential underlying molecular mechanisms. (See the Abbreviations section for complete definition of the abbreviations.)
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4477248&req=5

fig2: A summary of the published health benefits of resveratrol with the potential underlying molecular mechanisms. (See the Abbreviations section for complete definition of the abbreviations.)
Mentions: In brief, plethora of reports from in vitro and laboratory animal studies in the past decade has suggested that resveratrol has considerable potential for therapy and/or protection for numerous acute and chronic diseases. These data were supported, in most part, by the emerging results from limited human clinical trials. Larger controlled human clinical trials are still needed to investigate dose- and formulation-dependent efficacy and safety of resveratrol and to study the effect of long-term effect of resveratrol supplementation. Figure 2 provides a summary of the aforementioned health benefits of resveratrol with potential underlying molecular mechanisms.

Bottom Line: It is a bioactive molecule with physiological effects on multiple organ systems.Its effects range from the neuroprotective to the nephroprotective, including cardiovascular, neuronal, and antineoplastic responses as a part of its broad spectrum of action.We summarize the known anti-inflammatory, antioxidative, and cytoprotective effects of resveratrol across disparate organ systems.

View Article: PubMed Central - PubMed

Affiliation: School of Pharmacy, Pacific University, 222 SE 8th Avenue, Suite 451, Hillsboro, OR 97123, USA.

ABSTRACT
Resveratrol is a phenolic phytochemical, with a stilbene backbone, derived from edible plants such as grape and peanut. It is a bioactive molecule with physiological effects on multiple organ systems. Its effects range from the neuroprotective to the nephroprotective, including cardiovascular, neuronal, and antineoplastic responses as a part of its broad spectrum of action. In this review, we examine the effects of resveratrol on the following organ systems: the central nervous system, including neurological pathology such as Parkinson's and Alzheimer's disease; the cardiovascular system, including disorders such as atherosclerosis, ischemia-reperfusion injury, and cardiomyocyte hypertrophy; the kidneys, including primary and secondary nephropathies and nephrolithiasis; multiple forms of cancer; and metabolic syndromes including diabetes. We emphasize commonalities in extracellular matrix protein alterations and intracellular signal transduction system induction following resveratrol treatment. We summarize the known anti-inflammatory, antioxidative, and cytoprotective effects of resveratrol across disparate organ systems. Additionally, we analyze the available literature regarding the pharmacokinetics of resveratrol formulations used in these studies. Finally, we critically examine select clinical trials documenting a lack of effect following resveratrol treatment.

No MeSH data available.


Related in: MedlinePlus