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Resveratrol: A Focus on Several Neurodegenerative Diseases.

Tellone E, Galtieri A, Russo A, Giardina B, Ficarra S - Oxid Med Cell Longev (2015)

Bottom Line: Molecules of the plant world are proving their effectiveness in countering, slowing down, and regressing many diseases.The resveratrol for its intrinsic properties related to its stilbene structure has been proven to be a universal panacea, especially for a wide range of neurodegenerative diseases.What emerges is that, in the deep heterogeneity of the pathologies evaluated, resveratrol through a convergence on the protein targets is able to give therapeutic responses in neuronal cells deeply diversified not only in morphological structure but especially in their function performed in the anatomical district to which they belong.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemical Sciences, University of Messina, V. le Ferdinando Stagno d'Alcontres 31, 98166 Messina, Italy.

ABSTRACT
Molecules of the plant world are proving their effectiveness in countering, slowing down, and regressing many diseases. The resveratrol for its intrinsic properties related to its stilbene structure has been proven to be a universal panacea, especially for a wide range of neurodegenerative diseases. This paper evaluates (in vivo and in vitro) the various molecular targets of this peculiar polyphenol and its ability to effectively counter several neurodegenerative disorders such as Parkinson's, Alzheimer's, and Huntington's diseases and amyotrophic lateral sclerosis. What emerges is that, in the deep heterogeneity of the pathologies evaluated, resveratrol through a convergence on the protein targets is able to give therapeutic responses in neuronal cells deeply diversified not only in morphological structure but especially in their function performed in the anatomical district to which they belong.

No MeSH data available.


Related in: MedlinePlus

Global representation of RV targets in neurodegenerative protection.
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Related In: Results  -  Collection


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fig5: Global representation of RV targets in neurodegenerative protection.

Mentions: Hooper et al. [88] reported that p53 is upregulated approximately 2-fold in the superior temporal gyrus of AD and that p53 induces Tau indirect phosphorylation. Thus, p53 seems to play a pivotal role in AD implying that modulation of cell death pathways might be of therapeutic benefit (and indeed in other age related neurological disorders). The identification of p53 as a SIRT1 substrate highlights a further protective role of RV in AD-related cognitive decline. In fact, allosteric modulation of RV on SIRT1 activating deacetylation of p53 attenuates its activity [89]. Additionally, inhibition of p53 by RV might alter and in some way partially inhibit the GSK3β and p53 interaction. Since p53 and GSK3β are both involved in the apoptotic pathway (GSK3β overactivity leads to increased levels of plaques and tangles and p53 activity induces Tau phosphorylation), a strong RV effect may be speculated on AD against several molecular targets. Besides, Vingtdeux et al. [90] demonstrated the antiamyloidogenic effect of RV through activation of AMP-protein kinase (AMPK). AMPK is a heterotrimeric Ser/Thr protein kinase activated by different upstream kinases among which calcium/calmodulin-dependent protein kinase kinase-β (CamKKβ) is predominantly expressed in neuronal tissue [91]. AMPK signaling controls Aβ metabolism and RV increasing intracellular calcium levels promote AMPK activation by the CamKKβ pathway [90, 92–94]. Alterations of mitochondrial functioning followed by ROS generation are two alarming conditions known in aging and early stages of AD [95]. RV efficiently counteracts both pathological conditions, on the one hand through activation of SIRT1 and the PGC1α pathway that lead to improved mitochondrial function and efficiency and on the other hand through its antioxidant activity reducing ROS generation [31, 32, 96–98] (Figure 5).


Resveratrol: A Focus on Several Neurodegenerative Diseases.

Tellone E, Galtieri A, Russo A, Giardina B, Ficarra S - Oxid Med Cell Longev (2015)

Global representation of RV targets in neurodegenerative protection.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4477222&req=5

fig5: Global representation of RV targets in neurodegenerative protection.
Mentions: Hooper et al. [88] reported that p53 is upregulated approximately 2-fold in the superior temporal gyrus of AD and that p53 induces Tau indirect phosphorylation. Thus, p53 seems to play a pivotal role in AD implying that modulation of cell death pathways might be of therapeutic benefit (and indeed in other age related neurological disorders). The identification of p53 as a SIRT1 substrate highlights a further protective role of RV in AD-related cognitive decline. In fact, allosteric modulation of RV on SIRT1 activating deacetylation of p53 attenuates its activity [89]. Additionally, inhibition of p53 by RV might alter and in some way partially inhibit the GSK3β and p53 interaction. Since p53 and GSK3β are both involved in the apoptotic pathway (GSK3β overactivity leads to increased levels of plaques and tangles and p53 activity induces Tau phosphorylation), a strong RV effect may be speculated on AD against several molecular targets. Besides, Vingtdeux et al. [90] demonstrated the antiamyloidogenic effect of RV through activation of AMP-protein kinase (AMPK). AMPK is a heterotrimeric Ser/Thr protein kinase activated by different upstream kinases among which calcium/calmodulin-dependent protein kinase kinase-β (CamKKβ) is predominantly expressed in neuronal tissue [91]. AMPK signaling controls Aβ metabolism and RV increasing intracellular calcium levels promote AMPK activation by the CamKKβ pathway [90, 92–94]. Alterations of mitochondrial functioning followed by ROS generation are two alarming conditions known in aging and early stages of AD [95]. RV efficiently counteracts both pathological conditions, on the one hand through activation of SIRT1 and the PGC1α pathway that lead to improved mitochondrial function and efficiency and on the other hand through its antioxidant activity reducing ROS generation [31, 32, 96–98] (Figure 5).

Bottom Line: Molecules of the plant world are proving their effectiveness in countering, slowing down, and regressing many diseases.The resveratrol for its intrinsic properties related to its stilbene structure has been proven to be a universal panacea, especially for a wide range of neurodegenerative diseases.What emerges is that, in the deep heterogeneity of the pathologies evaluated, resveratrol through a convergence on the protein targets is able to give therapeutic responses in neuronal cells deeply diversified not only in morphological structure but especially in their function performed in the anatomical district to which they belong.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemical Sciences, University of Messina, V. le Ferdinando Stagno d'Alcontres 31, 98166 Messina, Italy.

ABSTRACT
Molecules of the plant world are proving their effectiveness in countering, slowing down, and regressing many diseases. The resveratrol for its intrinsic properties related to its stilbene structure has been proven to be a universal panacea, especially for a wide range of neurodegenerative diseases. This paper evaluates (in vivo and in vitro) the various molecular targets of this peculiar polyphenol and its ability to effectively counter several neurodegenerative disorders such as Parkinson's, Alzheimer's, and Huntington's diseases and amyotrophic lateral sclerosis. What emerges is that, in the deep heterogeneity of the pathologies evaluated, resveratrol through a convergence on the protein targets is able to give therapeutic responses in neuronal cells deeply diversified not only in morphological structure but especially in their function performed in the anatomical district to which they belong.

No MeSH data available.


Related in: MedlinePlus