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Resveratrol: A Focus on Several Neurodegenerative Diseases.

Tellone E, Galtieri A, Russo A, Giardina B, Ficarra S - Oxid Med Cell Longev (2015)

Bottom Line: Molecules of the plant world are proving their effectiveness in countering, slowing down, and regressing many diseases.The resveratrol for its intrinsic properties related to its stilbene structure has been proven to be a universal panacea, especially for a wide range of neurodegenerative diseases.What emerges is that, in the deep heterogeneity of the pathologies evaluated, resveratrol through a convergence on the protein targets is able to give therapeutic responses in neuronal cells deeply diversified not only in morphological structure but especially in their function performed in the anatomical district to which they belong.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemical Sciences, University of Messina, V. le Ferdinando Stagno d'Alcontres 31, 98166 Messina, Italy.

ABSTRACT
Molecules of the plant world are proving their effectiveness in countering, slowing down, and regressing many diseases. The resveratrol for its intrinsic properties related to its stilbene structure has been proven to be a universal panacea, especially for a wide range of neurodegenerative diseases. This paper evaluates (in vivo and in vitro) the various molecular targets of this peculiar polyphenol and its ability to effectively counter several neurodegenerative disorders such as Parkinson's, Alzheimer's, and Huntington's diseases and amyotrophic lateral sclerosis. What emerges is that, in the deep heterogeneity of the pathologies evaluated, resveratrol through a convergence on the protein targets is able to give therapeutic responses in neuronal cells deeply diversified not only in morphological structure but especially in their function performed in the anatomical district to which they belong.

No MeSH data available.


Related in: MedlinePlus

Main effects of RV.
© Copyright Policy - open-access
Related In: Results  -  Collection


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fig4: Main effects of RV.

Mentions: RV shows a moderate antioxidant activity towards the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, induces a significant reduction of superoxide anion, and decreases oxidation of hemoglobin, contributing to decreasing the superoxide concentration [31, 32]. In particular, RV action against oxidation of hemoglobin may be due to the action of its phenol groups which are able to reduce Fe3+ to Fe2+. It is also known that RV prevents low density lipoprotein (LDL) oxidation, responsible of atheromatous plaques in atherosclerosis disease [33]; in fact RV was shown to be more potent than flavonoids in preventing copper-catalyzed oxidation [34] and contributed to maintaining the levels of antioxidant enzymes like GPx, glutathione-S-transferase (GST) and reductase (GR), SOD, and CAT [35, 36]. Most likely part of beneficial properties of RV is probably related to concomitant downregulation of the expression of inducible NO synthase (iNOS) and upregulation of vasorelaxant endothelial NO synthase (eNOS) as observed by several studies [37–39]. Interestingly, RV acting as an antioxidant prevents the formation of toxic Aβ oligomers and protofibrillar intermediates, delaying the induced Aβ toxicity in different neuronal culture models [40]. These studies contributed to shedding light on the molecular mechanisms potentially involved in the beneficial effect of RV intake against AD (Figure 4) [41].


Resveratrol: A Focus on Several Neurodegenerative Diseases.

Tellone E, Galtieri A, Russo A, Giardina B, Ficarra S - Oxid Med Cell Longev (2015)

Main effects of RV.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4477222&req=5

fig4: Main effects of RV.
Mentions: RV shows a moderate antioxidant activity towards the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, induces a significant reduction of superoxide anion, and decreases oxidation of hemoglobin, contributing to decreasing the superoxide concentration [31, 32]. In particular, RV action against oxidation of hemoglobin may be due to the action of its phenol groups which are able to reduce Fe3+ to Fe2+. It is also known that RV prevents low density lipoprotein (LDL) oxidation, responsible of atheromatous plaques in atherosclerosis disease [33]; in fact RV was shown to be more potent than flavonoids in preventing copper-catalyzed oxidation [34] and contributed to maintaining the levels of antioxidant enzymes like GPx, glutathione-S-transferase (GST) and reductase (GR), SOD, and CAT [35, 36]. Most likely part of beneficial properties of RV is probably related to concomitant downregulation of the expression of inducible NO synthase (iNOS) and upregulation of vasorelaxant endothelial NO synthase (eNOS) as observed by several studies [37–39]. Interestingly, RV acting as an antioxidant prevents the formation of toxic Aβ oligomers and protofibrillar intermediates, delaying the induced Aβ toxicity in different neuronal culture models [40]. These studies contributed to shedding light on the molecular mechanisms potentially involved in the beneficial effect of RV intake against AD (Figure 4) [41].

Bottom Line: Molecules of the plant world are proving their effectiveness in countering, slowing down, and regressing many diseases.The resveratrol for its intrinsic properties related to its stilbene structure has been proven to be a universal panacea, especially for a wide range of neurodegenerative diseases.What emerges is that, in the deep heterogeneity of the pathologies evaluated, resveratrol through a convergence on the protein targets is able to give therapeutic responses in neuronal cells deeply diversified not only in morphological structure but especially in their function performed in the anatomical district to which they belong.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemical Sciences, University of Messina, V. le Ferdinando Stagno d'Alcontres 31, 98166 Messina, Italy.

ABSTRACT
Molecules of the plant world are proving their effectiveness in countering, slowing down, and regressing many diseases. The resveratrol for its intrinsic properties related to its stilbene structure has been proven to be a universal panacea, especially for a wide range of neurodegenerative diseases. This paper evaluates (in vivo and in vitro) the various molecular targets of this peculiar polyphenol and its ability to effectively counter several neurodegenerative disorders such as Parkinson's, Alzheimer's, and Huntington's diseases and amyotrophic lateral sclerosis. What emerges is that, in the deep heterogeneity of the pathologies evaluated, resveratrol through a convergence on the protein targets is able to give therapeutic responses in neuronal cells deeply diversified not only in morphological structure but especially in their function performed in the anatomical district to which they belong.

No MeSH data available.


Related in: MedlinePlus