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Resveratrol: A Focus on Several Neurodegenerative Diseases.

Tellone E, Galtieri A, Russo A, Giardina B, Ficarra S - Oxid Med Cell Longev (2015)

Bottom Line: Molecules of the plant world are proving their effectiveness in countering, slowing down, and regressing many diseases.The resveratrol for its intrinsic properties related to its stilbene structure has been proven to be a universal panacea, especially for a wide range of neurodegenerative diseases.What emerges is that, in the deep heterogeneity of the pathologies evaluated, resveratrol through a convergence on the protein targets is able to give therapeutic responses in neuronal cells deeply diversified not only in morphological structure but especially in their function performed in the anatomical district to which they belong.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemical Sciences, University of Messina, V. le Ferdinando Stagno d'Alcontres 31, 98166 Messina, Italy.

ABSTRACT
Molecules of the plant world are proving their effectiveness in countering, slowing down, and regressing many diseases. The resveratrol for its intrinsic properties related to its stilbene structure has been proven to be a universal panacea, especially for a wide range of neurodegenerative diseases. This paper evaluates (in vivo and in vitro) the various molecular targets of this peculiar polyphenol and its ability to effectively counter several neurodegenerative disorders such as Parkinson's, Alzheimer's, and Huntington's diseases and amyotrophic lateral sclerosis. What emerges is that, in the deep heterogeneity of the pathologies evaluated, resveratrol through a convergence on the protein targets is able to give therapeutic responses in neuronal cells deeply diversified not only in morphological structure but especially in their function performed in the anatomical district to which they belong.

No MeSH data available.


Related in: MedlinePlus

RV and neurodegenerative disease.
© Copyright Policy - open-access
Related In: Results  -  Collection


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fig3: RV and neurodegenerative disease.

Mentions: It is demonstrated yet that markers of oxidative stress precede pathologic lesions in AD, including senile plaques and neurofibrillary tangles [20]. Furthermore, ATP depletion or lipid and protein peroxidation induced by ROS is also implicated in PD and kills neurons by necrotic processes [21]; protein oxidative damage in the form of protein carbonyls and increased levels of 8-hydroxydeoxyguanosine are also present in PD brain and some evidences suggest a role for nitration and nitrosylation of certain proteins due to reactive nitrogen species [22, 23]. In this context, the linkage between neurodegenerative diseases and oxidative stress is largely investigated by researchers. Support for this curiosity comes from increasing attention to the efficacy of therapies with antioxidants and to the scavenger substances as protectors of nervous tissue from damage by oxidative stress. Clearly, strategies aimed at limiting free radical production, oxidative stress, and damage may slow the progression of neurodegenerative diseases. Actually there is a great interest to study the neuroprotective effects of natural products obtained from plants. There are several natural compounds with antioxidant properties which may contribute to counteracting oxidative stress by working to neutralize the excess free radicals and stopping them from starting the chain reactions that contribute to disease. In this context, RV for its chemical properties may be a very promising lead compound to counteract neuronal pathologies (Figure 3).


Resveratrol: A Focus on Several Neurodegenerative Diseases.

Tellone E, Galtieri A, Russo A, Giardina B, Ficarra S - Oxid Med Cell Longev (2015)

RV and neurodegenerative disease.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4477222&req=5

fig3: RV and neurodegenerative disease.
Mentions: It is demonstrated yet that markers of oxidative stress precede pathologic lesions in AD, including senile plaques and neurofibrillary tangles [20]. Furthermore, ATP depletion or lipid and protein peroxidation induced by ROS is also implicated in PD and kills neurons by necrotic processes [21]; protein oxidative damage in the form of protein carbonyls and increased levels of 8-hydroxydeoxyguanosine are also present in PD brain and some evidences suggest a role for nitration and nitrosylation of certain proteins due to reactive nitrogen species [22, 23]. In this context, the linkage between neurodegenerative diseases and oxidative stress is largely investigated by researchers. Support for this curiosity comes from increasing attention to the efficacy of therapies with antioxidants and to the scavenger substances as protectors of nervous tissue from damage by oxidative stress. Clearly, strategies aimed at limiting free radical production, oxidative stress, and damage may slow the progression of neurodegenerative diseases. Actually there is a great interest to study the neuroprotective effects of natural products obtained from plants. There are several natural compounds with antioxidant properties which may contribute to counteracting oxidative stress by working to neutralize the excess free radicals and stopping them from starting the chain reactions that contribute to disease. In this context, RV for its chemical properties may be a very promising lead compound to counteract neuronal pathologies (Figure 3).

Bottom Line: Molecules of the plant world are proving their effectiveness in countering, slowing down, and regressing many diseases.The resveratrol for its intrinsic properties related to its stilbene structure has been proven to be a universal panacea, especially for a wide range of neurodegenerative diseases.What emerges is that, in the deep heterogeneity of the pathologies evaluated, resveratrol through a convergence on the protein targets is able to give therapeutic responses in neuronal cells deeply diversified not only in morphological structure but especially in their function performed in the anatomical district to which they belong.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemical Sciences, University of Messina, V. le Ferdinando Stagno d'Alcontres 31, 98166 Messina, Italy.

ABSTRACT
Molecules of the plant world are proving their effectiveness in countering, slowing down, and regressing many diseases. The resveratrol for its intrinsic properties related to its stilbene structure has been proven to be a universal panacea, especially for a wide range of neurodegenerative diseases. This paper evaluates (in vivo and in vitro) the various molecular targets of this peculiar polyphenol and its ability to effectively counter several neurodegenerative disorders such as Parkinson's, Alzheimer's, and Huntington's diseases and amyotrophic lateral sclerosis. What emerges is that, in the deep heterogeneity of the pathologies evaluated, resveratrol through a convergence on the protein targets is able to give therapeutic responses in neuronal cells deeply diversified not only in morphological structure but especially in their function performed in the anatomical district to which they belong.

No MeSH data available.


Related in: MedlinePlus