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Resveratrol: A Focus on Several Neurodegenerative Diseases.

Tellone E, Galtieri A, Russo A, Giardina B, Ficarra S - Oxid Med Cell Longev (2015)

Bottom Line: Molecules of the plant world are proving their effectiveness in countering, slowing down, and regressing many diseases.The resveratrol for its intrinsic properties related to its stilbene structure has been proven to be a universal panacea, especially for a wide range of neurodegenerative diseases.What emerges is that, in the deep heterogeneity of the pathologies evaluated, resveratrol through a convergence on the protein targets is able to give therapeutic responses in neuronal cells deeply diversified not only in morphological structure but especially in their function performed in the anatomical district to which they belong.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemical Sciences, University of Messina, V. le Ferdinando Stagno d'Alcontres 31, 98166 Messina, Italy.

ABSTRACT
Molecules of the plant world are proving their effectiveness in countering, slowing down, and regressing many diseases. The resveratrol for its intrinsic properties related to its stilbene structure has been proven to be a universal panacea, especially for a wide range of neurodegenerative diseases. This paper evaluates (in vivo and in vitro) the various molecular targets of this peculiar polyphenol and its ability to effectively counter several neurodegenerative disorders such as Parkinson's, Alzheimer's, and Huntington's diseases and amyotrophic lateral sclerosis. What emerges is that, in the deep heterogeneity of the pathologies evaluated, resveratrol through a convergence on the protein targets is able to give therapeutic responses in neuronal cells deeply diversified not only in morphological structure but especially in their function performed in the anatomical district to which they belong.

No MeSH data available.


Related in: MedlinePlus

Antioxidant activity of RV against ROS.
© Copyright Policy - open-access
Related In: Results  -  Collection


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fig2: Antioxidant activity of RV against ROS.

Mentions: A suitable amount of free radicals is essential for life because they are involved in cell signaling and are used by phagocytes for their bactericidal action [7]. However, nonessential production of reactive oxygen species (ROS) is suggested to be strongly associated with the aging process and certain degenerative disorders. So to human health, the balance is very important between free radicals produced by metabolism or derived from environmental sources and the antioxidant defense systems such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) able to promptly scavenge and neutralize free radicals (Figure 2).


Resveratrol: A Focus on Several Neurodegenerative Diseases.

Tellone E, Galtieri A, Russo A, Giardina B, Ficarra S - Oxid Med Cell Longev (2015)

Antioxidant activity of RV against ROS.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4477222&req=5

fig2: Antioxidant activity of RV against ROS.
Mentions: A suitable amount of free radicals is essential for life because they are involved in cell signaling and are used by phagocytes for their bactericidal action [7]. However, nonessential production of reactive oxygen species (ROS) is suggested to be strongly associated with the aging process and certain degenerative disorders. So to human health, the balance is very important between free radicals produced by metabolism or derived from environmental sources and the antioxidant defense systems such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) able to promptly scavenge and neutralize free radicals (Figure 2).

Bottom Line: Molecules of the plant world are proving their effectiveness in countering, slowing down, and regressing many diseases.The resveratrol for its intrinsic properties related to its stilbene structure has been proven to be a universal panacea, especially for a wide range of neurodegenerative diseases.What emerges is that, in the deep heterogeneity of the pathologies evaluated, resveratrol through a convergence on the protein targets is able to give therapeutic responses in neuronal cells deeply diversified not only in morphological structure but especially in their function performed in the anatomical district to which they belong.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemical Sciences, University of Messina, V. le Ferdinando Stagno d'Alcontres 31, 98166 Messina, Italy.

ABSTRACT
Molecules of the plant world are proving their effectiveness in countering, slowing down, and regressing many diseases. The resveratrol for its intrinsic properties related to its stilbene structure has been proven to be a universal panacea, especially for a wide range of neurodegenerative diseases. This paper evaluates (in vivo and in vitro) the various molecular targets of this peculiar polyphenol and its ability to effectively counter several neurodegenerative disorders such as Parkinson's, Alzheimer's, and Huntington's diseases and amyotrophic lateral sclerosis. What emerges is that, in the deep heterogeneity of the pathologies evaluated, resveratrol through a convergence on the protein targets is able to give therapeutic responses in neuronal cells deeply diversified not only in morphological structure but especially in their function performed in the anatomical district to which they belong.

No MeSH data available.


Related in: MedlinePlus