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Resveratrol: A Focus on Several Neurodegenerative Diseases.

Tellone E, Galtieri A, Russo A, Giardina B, Ficarra S - Oxid Med Cell Longev (2015)

Bottom Line: Molecules of the plant world are proving their effectiveness in countering, slowing down, and regressing many diseases.The resveratrol for its intrinsic properties related to its stilbene structure has been proven to be a universal panacea, especially for a wide range of neurodegenerative diseases.What emerges is that, in the deep heterogeneity of the pathologies evaluated, resveratrol through a convergence on the protein targets is able to give therapeutic responses in neuronal cells deeply diversified not only in morphological structure but especially in their function performed in the anatomical district to which they belong.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemical Sciences, University of Messina, V. le Ferdinando Stagno d'Alcontres 31, 98166 Messina, Italy.

ABSTRACT
Molecules of the plant world are proving their effectiveness in countering, slowing down, and regressing many diseases. The resveratrol for its intrinsic properties related to its stilbene structure has been proven to be a universal panacea, especially for a wide range of neurodegenerative diseases. This paper evaluates (in vivo and in vitro) the various molecular targets of this peculiar polyphenol and its ability to effectively counter several neurodegenerative disorders such as Parkinson's, Alzheimer's, and Huntington's diseases and amyotrophic lateral sclerosis. What emerges is that, in the deep heterogeneity of the pathologies evaluated, resveratrol through a convergence on the protein targets is able to give therapeutic responses in neuronal cells deeply diversified not only in morphological structure but especially in their function performed in the anatomical district to which they belong.

No MeSH data available.


Related in: MedlinePlus

Biosynthetic pathway of RV.
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Related In: Results  -  Collection


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fig1: Biosynthetic pathway of RV.

Mentions: Resveratrol (RV), or 3,5,4′-trihydroxy-trans-stilbene, is an antifungal molecule of the stilbene family produced in a variety of plant species in response to pathogen attack or under stress conditions such as UV radiation and exposure to heavy metal ions [1]. It is a natural phenol found in red grapes, mulberries, peanuts, wines, and tea and it can be extracted from red wine during fermentation of grape skin. RV exists in two isoforms: trans-RV, the more stable form, and cis-isomer, both produced as a branch from the phenylpropanoid pathway [2]. In plants, RV biosynthesis starts by the coupling of p-coumaric acid, an intermediate in lignin production, to coenzyme A (CoA) by the action of 4-coumarate CoA ligase (4CL); see Figure 1. Subsequently, coumaroyl-CoA is converted into RV with release of carbon dioxide, by sequential addition of three units of malonyl-CoA by the action of stilbene synthase (STS) [3].


Resveratrol: A Focus on Several Neurodegenerative Diseases.

Tellone E, Galtieri A, Russo A, Giardina B, Ficarra S - Oxid Med Cell Longev (2015)

Biosynthetic pathway of RV.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4477222&req=5

fig1: Biosynthetic pathway of RV.
Mentions: Resveratrol (RV), or 3,5,4′-trihydroxy-trans-stilbene, is an antifungal molecule of the stilbene family produced in a variety of plant species in response to pathogen attack or under stress conditions such as UV radiation and exposure to heavy metal ions [1]. It is a natural phenol found in red grapes, mulberries, peanuts, wines, and tea and it can be extracted from red wine during fermentation of grape skin. RV exists in two isoforms: trans-RV, the more stable form, and cis-isomer, both produced as a branch from the phenylpropanoid pathway [2]. In plants, RV biosynthesis starts by the coupling of p-coumaric acid, an intermediate in lignin production, to coenzyme A (CoA) by the action of 4-coumarate CoA ligase (4CL); see Figure 1. Subsequently, coumaroyl-CoA is converted into RV with release of carbon dioxide, by sequential addition of three units of malonyl-CoA by the action of stilbene synthase (STS) [3].

Bottom Line: Molecules of the plant world are proving their effectiveness in countering, slowing down, and regressing many diseases.The resveratrol for its intrinsic properties related to its stilbene structure has been proven to be a universal panacea, especially for a wide range of neurodegenerative diseases.What emerges is that, in the deep heterogeneity of the pathologies evaluated, resveratrol through a convergence on the protein targets is able to give therapeutic responses in neuronal cells deeply diversified not only in morphological structure but especially in their function performed in the anatomical district to which they belong.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemical Sciences, University of Messina, V. le Ferdinando Stagno d'Alcontres 31, 98166 Messina, Italy.

ABSTRACT
Molecules of the plant world are proving their effectiveness in countering, slowing down, and regressing many diseases. The resveratrol for its intrinsic properties related to its stilbene structure has been proven to be a universal panacea, especially for a wide range of neurodegenerative diseases. This paper evaluates (in vivo and in vitro) the various molecular targets of this peculiar polyphenol and its ability to effectively counter several neurodegenerative disorders such as Parkinson's, Alzheimer's, and Huntington's diseases and amyotrophic lateral sclerosis. What emerges is that, in the deep heterogeneity of the pathologies evaluated, resveratrol through a convergence on the protein targets is able to give therapeutic responses in neuronal cells deeply diversified not only in morphological structure but especially in their function performed in the anatomical district to which they belong.

No MeSH data available.


Related in: MedlinePlus