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Polyphenol Stilbenes: Molecular Mechanisms of Defence against Oxidative Stress and Aging-Related Diseases.

Reinisalo M, Kårlund A, Koskela A, Kaarniranta K, Karjalainen RO - Oxid Med Cell Longev (2015)

Bottom Line: There is convincing data that stilbene compounds, a diverse group of natural defence phenolics, abundant in grapes, berries, and conifer bark waste, may confer a protective effect against aging-related diseases.The impact of stilbenes on the nuclear factor-erythroid-2-related factor-2 (Nrf2) mediated cellular defence against oxidative stress as well as the potential roles of SQSTM1/p62 protein in Nrf2/Keap1 signaling and autophagy will be summarized.The therapeutic potential of stilbene compounds against the most common aging-related diseases is discussed.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland.

ABSTRACT
Numerous studies have highlighted the key roles of oxidative stress and inflammation in aging-related diseases such as obesity, type 2 diabetes, age-related macular degeneration (AMD), and Alzheimer's disease (AD). In aging cells, the natural antioxidant capacity decreases and the overall efficiency of reparative systems against cell damage becomes impaired. There is convincing data that stilbene compounds, a diverse group of natural defence phenolics, abundant in grapes, berries, and conifer bark waste, may confer a protective effect against aging-related diseases. This review highlights recent data helping to clarify the molecular mechanisms involved in the stilbene-mediated protection against oxidative stress. The impact of stilbenes on the nuclear factor-erythroid-2-related factor-2 (Nrf2) mediated cellular defence against oxidative stress as well as the potential roles of SQSTM1/p62 protein in Nrf2/Keap1 signaling and autophagy will be summarized. The therapeutic potential of stilbene compounds against the most common aging-related diseases is discussed.

No MeSH data available.


Related in: MedlinePlus

Schematic diagram showing the potential beneficial actions of stilbenes in prevention of age-related diseases.
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fig3: Schematic diagram showing the potential beneficial actions of stilbenes in prevention of age-related diseases.

Mentions: There is emerging in vitro and preclinical data to indicate that stilbene compounds are capable of suppressing oxidative stress, inflammation, and energy expenditure as well as modulating the secretion of neurotropic factors. However, most of the available experimental data has concentrated on resveratrol and only limited research has been carried out with the other stilbene compounds. These other stilbenes such as pinosylvin, piceatannol, and pterostilbene may have higher biological activity than resveratrol and deserve to receive more scientific attention. The limited bioavailability, the low target specificity, and the rapid metabolism of stilbenes represent obstacles to achieving high enough concentrations of these compounds in plasma and the target tissue in order that they can exert their beneficial actions. However, recent investigations into the biological activity of polyphenol metabolites have been promising. Unlike drugs, stilbene-like polyphenols affect several key metabolic pathways (Figure 3), and promising therapeutic approaches may require focusing on multiple targets. This may lead to the development of next-generation functional type foods and supplements for slowing down the increasingly common diseases such as obesity, T2D, AMD, and AD.


Polyphenol Stilbenes: Molecular Mechanisms of Defence against Oxidative Stress and Aging-Related Diseases.

Reinisalo M, Kårlund A, Koskela A, Kaarniranta K, Karjalainen RO - Oxid Med Cell Longev (2015)

Schematic diagram showing the potential beneficial actions of stilbenes in prevention of age-related diseases.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4477219&req=5

fig3: Schematic diagram showing the potential beneficial actions of stilbenes in prevention of age-related diseases.
Mentions: There is emerging in vitro and preclinical data to indicate that stilbene compounds are capable of suppressing oxidative stress, inflammation, and energy expenditure as well as modulating the secretion of neurotropic factors. However, most of the available experimental data has concentrated on resveratrol and only limited research has been carried out with the other stilbene compounds. These other stilbenes such as pinosylvin, piceatannol, and pterostilbene may have higher biological activity than resveratrol and deserve to receive more scientific attention. The limited bioavailability, the low target specificity, and the rapid metabolism of stilbenes represent obstacles to achieving high enough concentrations of these compounds in plasma and the target tissue in order that they can exert their beneficial actions. However, recent investigations into the biological activity of polyphenol metabolites have been promising. Unlike drugs, stilbene-like polyphenols affect several key metabolic pathways (Figure 3), and promising therapeutic approaches may require focusing on multiple targets. This may lead to the development of next-generation functional type foods and supplements for slowing down the increasingly common diseases such as obesity, T2D, AMD, and AD.

Bottom Line: There is convincing data that stilbene compounds, a diverse group of natural defence phenolics, abundant in grapes, berries, and conifer bark waste, may confer a protective effect against aging-related diseases.The impact of stilbenes on the nuclear factor-erythroid-2-related factor-2 (Nrf2) mediated cellular defence against oxidative stress as well as the potential roles of SQSTM1/p62 protein in Nrf2/Keap1 signaling and autophagy will be summarized.The therapeutic potential of stilbene compounds against the most common aging-related diseases is discussed.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland.

ABSTRACT
Numerous studies have highlighted the key roles of oxidative stress and inflammation in aging-related diseases such as obesity, type 2 diabetes, age-related macular degeneration (AMD), and Alzheimer's disease (AD). In aging cells, the natural antioxidant capacity decreases and the overall efficiency of reparative systems against cell damage becomes impaired. There is convincing data that stilbene compounds, a diverse group of natural defence phenolics, abundant in grapes, berries, and conifer bark waste, may confer a protective effect against aging-related diseases. This review highlights recent data helping to clarify the molecular mechanisms involved in the stilbene-mediated protection against oxidative stress. The impact of stilbenes on the nuclear factor-erythroid-2-related factor-2 (Nrf2) mediated cellular defence against oxidative stress as well as the potential roles of SQSTM1/p62 protein in Nrf2/Keap1 signaling and autophagy will be summarized. The therapeutic potential of stilbene compounds against the most common aging-related diseases is discussed.

No MeSH data available.


Related in: MedlinePlus