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Polyphenol Stilbenes: Molecular Mechanisms of Defence against Oxidative Stress and Aging-Related Diseases.

Reinisalo M, Kårlund A, Koskela A, Kaarniranta K, Karjalainen RO - Oxid Med Cell Longev (2015)

Bottom Line: There is convincing data that stilbene compounds, a diverse group of natural defence phenolics, abundant in grapes, berries, and conifer bark waste, may confer a protective effect against aging-related diseases.The impact of stilbenes on the nuclear factor-erythroid-2-related factor-2 (Nrf2) mediated cellular defence against oxidative stress as well as the potential roles of SQSTM1/p62 protein in Nrf2/Keap1 signaling and autophagy will be summarized.The therapeutic potential of stilbene compounds against the most common aging-related diseases is discussed.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland.

ABSTRACT
Numerous studies have highlighted the key roles of oxidative stress and inflammation in aging-related diseases such as obesity, type 2 diabetes, age-related macular degeneration (AMD), and Alzheimer's disease (AD). In aging cells, the natural antioxidant capacity decreases and the overall efficiency of reparative systems against cell damage becomes impaired. There is convincing data that stilbene compounds, a diverse group of natural defence phenolics, abundant in grapes, berries, and conifer bark waste, may confer a protective effect against aging-related diseases. This review highlights recent data helping to clarify the molecular mechanisms involved in the stilbene-mediated protection against oxidative stress. The impact of stilbenes on the nuclear factor-erythroid-2-related factor-2 (Nrf2) mediated cellular defence against oxidative stress as well as the potential roles of SQSTM1/p62 protein in Nrf2/Keap1 signaling and autophagy will be summarized. The therapeutic potential of stilbene compounds against the most common aging-related diseases is discussed.

No MeSH data available.


Related in: MedlinePlus

As an individual ages, the balance between a long, healthy lifespan and suffering age-related diseases is believed to be related to the interplay between the cellular antioxidant defence system and adverse effects related to oxidative stress. In aging cells, oxidative stress increases due to a progressive decline in the efficiency of antioxidant defence systems. There is convincing evidence to indicate that supplementation with polyphenols, such as stilbenes, anthocyanins, and catechins, can increase cellular antioxidant defence and promote health of the individual.
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fig1: As an individual ages, the balance between a long, healthy lifespan and suffering age-related diseases is believed to be related to the interplay between the cellular antioxidant defence system and adverse effects related to oxidative stress. In aging cells, oxidative stress increases due to a progressive decline in the efficiency of antioxidant defence systems. There is convincing evidence to indicate that supplementation with polyphenols, such as stilbenes, anthocyanins, and catechins, can increase cellular antioxidant defence and promote health of the individual.

Mentions: Aging is one of the major risk factors for a wide range of chronic, metabolic, and neurodegenerative diseases. During the course of aging, reactive oxygen species (ROS) cause increasing oxidative stress in cells leading to oxidative damage and to the induction of inflammatory cascades (Figure 1). Furthermore, antioxidant defence systems against oxidative stress deteriorate during aging and many antioxidant phase II genes are upregulated only marginally or may even be downregulated. Moreover, the innate and adaptive immune defence systems tend to deteriorate during aging and this may contribute to the degeneration process [1].


Polyphenol Stilbenes: Molecular Mechanisms of Defence against Oxidative Stress and Aging-Related Diseases.

Reinisalo M, Kårlund A, Koskela A, Kaarniranta K, Karjalainen RO - Oxid Med Cell Longev (2015)

As an individual ages, the balance between a long, healthy lifespan and suffering age-related diseases is believed to be related to the interplay between the cellular antioxidant defence system and adverse effects related to oxidative stress. In aging cells, oxidative stress increases due to a progressive decline in the efficiency of antioxidant defence systems. There is convincing evidence to indicate that supplementation with polyphenols, such as stilbenes, anthocyanins, and catechins, can increase cellular antioxidant defence and promote health of the individual.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4477219&req=5

fig1: As an individual ages, the balance between a long, healthy lifespan and suffering age-related diseases is believed to be related to the interplay between the cellular antioxidant defence system and adverse effects related to oxidative stress. In aging cells, oxidative stress increases due to a progressive decline in the efficiency of antioxidant defence systems. There is convincing evidence to indicate that supplementation with polyphenols, such as stilbenes, anthocyanins, and catechins, can increase cellular antioxidant defence and promote health of the individual.
Mentions: Aging is one of the major risk factors for a wide range of chronic, metabolic, and neurodegenerative diseases. During the course of aging, reactive oxygen species (ROS) cause increasing oxidative stress in cells leading to oxidative damage and to the induction of inflammatory cascades (Figure 1). Furthermore, antioxidant defence systems against oxidative stress deteriorate during aging and many antioxidant phase II genes are upregulated only marginally or may even be downregulated. Moreover, the innate and adaptive immune defence systems tend to deteriorate during aging and this may contribute to the degeneration process [1].

Bottom Line: There is convincing data that stilbene compounds, a diverse group of natural defence phenolics, abundant in grapes, berries, and conifer bark waste, may confer a protective effect against aging-related diseases.The impact of stilbenes on the nuclear factor-erythroid-2-related factor-2 (Nrf2) mediated cellular defence against oxidative stress as well as the potential roles of SQSTM1/p62 protein in Nrf2/Keap1 signaling and autophagy will be summarized.The therapeutic potential of stilbene compounds against the most common aging-related diseases is discussed.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland.

ABSTRACT
Numerous studies have highlighted the key roles of oxidative stress and inflammation in aging-related diseases such as obesity, type 2 diabetes, age-related macular degeneration (AMD), and Alzheimer's disease (AD). In aging cells, the natural antioxidant capacity decreases and the overall efficiency of reparative systems against cell damage becomes impaired. There is convincing data that stilbene compounds, a diverse group of natural defence phenolics, abundant in grapes, berries, and conifer bark waste, may confer a protective effect against aging-related diseases. This review highlights recent data helping to clarify the molecular mechanisms involved in the stilbene-mediated protection against oxidative stress. The impact of stilbenes on the nuclear factor-erythroid-2-related factor-2 (Nrf2) mediated cellular defence against oxidative stress as well as the potential roles of SQSTM1/p62 protein in Nrf2/Keap1 signaling and autophagy will be summarized. The therapeutic potential of stilbene compounds against the most common aging-related diseases is discussed.

No MeSH data available.


Related in: MedlinePlus