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Leptin as well as Free Leptin Receptor Is Associated with Polycystic Ovary Syndrome in Young Women.

Rizk NM, Sharif E - Int J Endocrinol (2015)

Bottom Line: However, body mass index (BMI) is significantly correlated with leptin and s-OBR, while no significant correlations with parameters of insulin resistance were detected.Conclusion.Decreased sOB-R could be a compensatory mechanism for the defective action of leptin.

View Article: PubMed Central - PubMed

Affiliation: Health Sciences Department, CAS, Qatar University, P.O. Box 2713, Doha, Qatar.

ABSTRACT
Background and Aim. Leptin has two forms in the circulation: free and bound forms. The soluble leptin receptor (sOB-R) circulates in the blood and can bind to leptin. The aim of this study is to assess the concentrations of the leptin and the sOB-R in PCOS and its relation to adiposity, insulin resistance, and androgens. Methods. A cross-sectional study included 78 female students aged 17-25 years. Fasting serum leptin and sOB-R concentrations were measured. The anthropometric variables and the hormonal profile such as insulin, female and male sex hormones, and prolactin were assessed. Results. In PCOS, leptin level (ng/ml) and free leptin index (FLI) increased significantly while sOB-R (ng/ml) significantly decreased compared to control subjects. In age-matched subjects, obese PCOS had increased leptin level in ng/ml (median level with interquartile levels) of 45.67 (41.98-48.04) and decreased sOB-R in ng/ml 11.47 (7.59-16.44) compared to lean PCOS 16.97 (10.60-45.55) for leptin and 16.62 (11.61-17.96) for sOB-R with p values 0.013 and 0.042, respectively. However, body mass index (BMI) is significantly correlated with leptin and s-OBR, while no significant correlations with parameters of insulin resistance were detected. Conclusion. PCOS is associated with hyperleptinemia and increased free leptin index. Decreased sOB-R could be a compensatory mechanism for the defective action of leptin.

No MeSH data available.


Related in: MedlinePlus

Odds ratio and (95% CI) for PCOS with the individual independent variables were analyzed by the logistic regression analysis. PCOS was diagnosed by NIH criteria. Two-tailed p-value is significant at ≤0.05.
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fig2: Odds ratio and (95% CI) for PCOS with the individual independent variables were analyzed by the logistic regression analysis. PCOS was diagnosed by NIH criteria. Two-tailed p-value is significant at ≤0.05.

Mentions: Regression analysis showed a significant positive correlation between leptin and BMI (r = 0.588, p = 0.011) and a significant negative correlation between sOB-R and BMI (r = −0.443, p = 0.048) in PCOS subjects (data are not shown, in omitted figures). Therefore, BMI was included in the partial correlation analysis since it significantly associated with leptin and its soluble receptor. The partial coefficient correlation analysis revealed that leptin level had a significant positive correlation with PCOS and negative correlation with sOB-R. The soluble leptin receptor is significantly associated inversely with leptin and PCOS. PCOS is directly significantly correlated with free testosterone, DHEAS, FAI, irregular menstrual cycles, and leptin and inversely with sOB-R, as shown in Table 4. Further we calculated the odds ratio and 95% confidence intervals (CI) (Figure 2) between PCOS as a dependent variable and the following independent variables BMI and HOMA-IR in addition to the following variables: free testosterone, leptin, DHEAS, and menstrual cycle, which showed significant associations with PCOS and leptin.


Leptin as well as Free Leptin Receptor Is Associated with Polycystic Ovary Syndrome in Young Women.

Rizk NM, Sharif E - Int J Endocrinol (2015)

Odds ratio and (95% CI) for PCOS with the individual independent variables were analyzed by the logistic regression analysis. PCOS was diagnosed by NIH criteria. Two-tailed p-value is significant at ≤0.05.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4477211&req=5

fig2: Odds ratio and (95% CI) for PCOS with the individual independent variables were analyzed by the logistic regression analysis. PCOS was diagnosed by NIH criteria. Two-tailed p-value is significant at ≤0.05.
Mentions: Regression analysis showed a significant positive correlation between leptin and BMI (r = 0.588, p = 0.011) and a significant negative correlation between sOB-R and BMI (r = −0.443, p = 0.048) in PCOS subjects (data are not shown, in omitted figures). Therefore, BMI was included in the partial correlation analysis since it significantly associated with leptin and its soluble receptor. The partial coefficient correlation analysis revealed that leptin level had a significant positive correlation with PCOS and negative correlation with sOB-R. The soluble leptin receptor is significantly associated inversely with leptin and PCOS. PCOS is directly significantly correlated with free testosterone, DHEAS, FAI, irregular menstrual cycles, and leptin and inversely with sOB-R, as shown in Table 4. Further we calculated the odds ratio and 95% confidence intervals (CI) (Figure 2) between PCOS as a dependent variable and the following independent variables BMI and HOMA-IR in addition to the following variables: free testosterone, leptin, DHEAS, and menstrual cycle, which showed significant associations with PCOS and leptin.

Bottom Line: However, body mass index (BMI) is significantly correlated with leptin and s-OBR, while no significant correlations with parameters of insulin resistance were detected.Conclusion.Decreased sOB-R could be a compensatory mechanism for the defective action of leptin.

View Article: PubMed Central - PubMed

Affiliation: Health Sciences Department, CAS, Qatar University, P.O. Box 2713, Doha, Qatar.

ABSTRACT
Background and Aim. Leptin has two forms in the circulation: free and bound forms. The soluble leptin receptor (sOB-R) circulates in the blood and can bind to leptin. The aim of this study is to assess the concentrations of the leptin and the sOB-R in PCOS and its relation to adiposity, insulin resistance, and androgens. Methods. A cross-sectional study included 78 female students aged 17-25 years. Fasting serum leptin and sOB-R concentrations were measured. The anthropometric variables and the hormonal profile such as insulin, female and male sex hormones, and prolactin were assessed. Results. In PCOS, leptin level (ng/ml) and free leptin index (FLI) increased significantly while sOB-R (ng/ml) significantly decreased compared to control subjects. In age-matched subjects, obese PCOS had increased leptin level in ng/ml (median level with interquartile levels) of 45.67 (41.98-48.04) and decreased sOB-R in ng/ml 11.47 (7.59-16.44) compared to lean PCOS 16.97 (10.60-45.55) for leptin and 16.62 (11.61-17.96) for sOB-R with p values 0.013 and 0.042, respectively. However, body mass index (BMI) is significantly correlated with leptin and s-OBR, while no significant correlations with parameters of insulin resistance were detected. Conclusion. PCOS is associated with hyperleptinemia and increased free leptin index. Decreased sOB-R could be a compensatory mechanism for the defective action of leptin.

No MeSH data available.


Related in: MedlinePlus