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Leptin as well as Free Leptin Receptor Is Associated with Polycystic Ovary Syndrome in Young Women.

Rizk NM, Sharif E - Int J Endocrinol (2015)

Bottom Line: However, body mass index (BMI) is significantly correlated with leptin and s-OBR, while no significant correlations with parameters of insulin resistance were detected.Conclusion.Decreased sOB-R could be a compensatory mechanism for the defective action of leptin.

View Article: PubMed Central - PubMed

Affiliation: Health Sciences Department, CAS, Qatar University, P.O. Box 2713, Doha, Qatar.

ABSTRACT
Background and Aim. Leptin has two forms in the circulation: free and bound forms. The soluble leptin receptor (sOB-R) circulates in the blood and can bind to leptin. The aim of this study is to assess the concentrations of the leptin and the sOB-R in PCOS and its relation to adiposity, insulin resistance, and androgens. Methods. A cross-sectional study included 78 female students aged 17-25 years. Fasting serum leptin and sOB-R concentrations were measured. The anthropometric variables and the hormonal profile such as insulin, female and male sex hormones, and prolactin were assessed. Results. In PCOS, leptin level (ng/ml) and free leptin index (FLI) increased significantly while sOB-R (ng/ml) significantly decreased compared to control subjects. In age-matched subjects, obese PCOS had increased leptin level in ng/ml (median level with interquartile levels) of 45.67 (41.98-48.04) and decreased sOB-R in ng/ml 11.47 (7.59-16.44) compared to lean PCOS 16.97 (10.60-45.55) for leptin and 16.62 (11.61-17.96) for sOB-R with p values 0.013 and 0.042, respectively. However, body mass index (BMI) is significantly correlated with leptin and s-OBR, while no significant correlations with parameters of insulin resistance were detected. Conclusion. PCOS is associated with hyperleptinemia and increased free leptin index. Decreased sOB-R could be a compensatory mechanism for the defective action of leptin.

No MeSH data available.


Related in: MedlinePlus

Free leptin index levels among the study subjects based on the presence of PCOS, OW/OB, and insulin resistance. Data are presented by median and interquartile (IQ) values (25%–75%). Data were analyzed by nonparametric Mann-Whitney test. p values are shown between different groups. Two-tailed p-value is significant at ≤0.05.
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fig1: Free leptin index levels among the study subjects based on the presence of PCOS, OW/OB, and insulin resistance. Data are presented by median and interquartile (IQ) values (25%–75%). Data were analyzed by nonparametric Mann-Whitney test. p values are shown between different groups. Two-tailed p-value is significant at ≤0.05.

Mentions: Furthermore, we classified the study groups in subjects with and without the insulin resistance. In addition, the frequency of IR was evident in 24/78 (30.77%) in all study subjects. IR was insignificantly higher (9/22 or 40.91%) in OW/OB subjects than in lean subjects (15/56 or 26.79%), p = 0.278. In addition, IR was more prevalent in OW/OB PCOS (5/8 or 62.5%) than in lean PCOS (3/10 or 30.0%) with p value = 0.133.


Leptin as well as Free Leptin Receptor Is Associated with Polycystic Ovary Syndrome in Young Women.

Rizk NM, Sharif E - Int J Endocrinol (2015)

Free leptin index levels among the study subjects based on the presence of PCOS, OW/OB, and insulin resistance. Data are presented by median and interquartile (IQ) values (25%–75%). Data were analyzed by nonparametric Mann-Whitney test. p values are shown between different groups. Two-tailed p-value is significant at ≤0.05.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4477211&req=5

fig1: Free leptin index levels among the study subjects based on the presence of PCOS, OW/OB, and insulin resistance. Data are presented by median and interquartile (IQ) values (25%–75%). Data were analyzed by nonparametric Mann-Whitney test. p values are shown between different groups. Two-tailed p-value is significant at ≤0.05.
Mentions: Furthermore, we classified the study groups in subjects with and without the insulin resistance. In addition, the frequency of IR was evident in 24/78 (30.77%) in all study subjects. IR was insignificantly higher (9/22 or 40.91%) in OW/OB subjects than in lean subjects (15/56 or 26.79%), p = 0.278. In addition, IR was more prevalent in OW/OB PCOS (5/8 or 62.5%) than in lean PCOS (3/10 or 30.0%) with p value = 0.133.

Bottom Line: However, body mass index (BMI) is significantly correlated with leptin and s-OBR, while no significant correlations with parameters of insulin resistance were detected.Conclusion.Decreased sOB-R could be a compensatory mechanism for the defective action of leptin.

View Article: PubMed Central - PubMed

Affiliation: Health Sciences Department, CAS, Qatar University, P.O. Box 2713, Doha, Qatar.

ABSTRACT
Background and Aim. Leptin has two forms in the circulation: free and bound forms. The soluble leptin receptor (sOB-R) circulates in the blood and can bind to leptin. The aim of this study is to assess the concentrations of the leptin and the sOB-R in PCOS and its relation to adiposity, insulin resistance, and androgens. Methods. A cross-sectional study included 78 female students aged 17-25 years. Fasting serum leptin and sOB-R concentrations were measured. The anthropometric variables and the hormonal profile such as insulin, female and male sex hormones, and prolactin were assessed. Results. In PCOS, leptin level (ng/ml) and free leptin index (FLI) increased significantly while sOB-R (ng/ml) significantly decreased compared to control subjects. In age-matched subjects, obese PCOS had increased leptin level in ng/ml (median level with interquartile levels) of 45.67 (41.98-48.04) and decreased sOB-R in ng/ml 11.47 (7.59-16.44) compared to lean PCOS 16.97 (10.60-45.55) for leptin and 16.62 (11.61-17.96) for sOB-R with p values 0.013 and 0.042, respectively. However, body mass index (BMI) is significantly correlated with leptin and s-OBR, while no significant correlations with parameters of insulin resistance were detected. Conclusion. PCOS is associated with hyperleptinemia and increased free leptin index. Decreased sOB-R could be a compensatory mechanism for the defective action of leptin.

No MeSH data available.


Related in: MedlinePlus