Limits...
Extranodal Rosai-Dorfman Disease Involving the Left Atrium: Cardiac MRI, CT, and PET Scan Findings.

Daruwalla VJ, Parekh K, Tahir H, Collins JD, Carr J - Case Rep Radiol (2015)

Bottom Line: Rosai-Dorfman disease (RDD) is a rare entity that usually involves the lymph nodes but extranodal involvements have been seen in numerous cases, although RDD with cardiovascular involvement is extremely rare.We describe a case of a young male who presented with intermittent palpitations and was found to have a left atrium mass.RDD should be considered as one of the differentials even for isolated cardiac lesions.

View Article: PubMed Central - PubMed

Affiliation: Conemaugh Memorial Hospital/Temple University, 1199 Mckinley Avenue, Johnstown, PA 15905, USA.

ABSTRACT
Rosai-Dorfman disease (RDD) is a rare entity that usually involves the lymph nodes but extranodal involvements have been seen in numerous cases, although RDD with cardiovascular involvement is extremely rare. We describe a case of a young male who presented with intermittent palpitations and was found to have a left atrium mass. Our case not only emphasizes the rarity of the above lesion but also highlights the importance of modern-day imaging like computed tomography, Cardiac Magnetic Resonance Imaging (CMRI), and PET scan in characterizing such nonspecific lesions and directing appropriate line of treatment. RDD should be considered as one of the differentials even for isolated cardiac lesions.

No MeSH data available.


Related in: MedlinePlus

Immunohistopathology. Section through the left atrial mass shows histiocytes that are immunoreactive to S100 protein immunostaining (a). Emperipolesis is engulfment of lymphocytes and erythrocytes by histiocytes that is considered diagnostic of RDD. Emperipolesis is noted in section from left atrial mass on hematoxylin and eosin-stained sections (b). The histiocytes and lymphoplasmacytic cells infiltrating the myocardium of the left atrium are seen (c). Section from the left atrium also demonstrates fibrosis and large histiocytes in sheets that are accompanied by numerous plasma cells and small mature lymphocytes mass on hematoxylin and eosin-stained section (d).
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4477210&req=5

fig5: Immunohistopathology. Section through the left atrial mass shows histiocytes that are immunoreactive to S100 protein immunostaining (a). Emperipolesis is engulfment of lymphocytes and erythrocytes by histiocytes that is considered diagnostic of RDD. Emperipolesis is noted in section from left atrial mass on hematoxylin and eosin-stained sections (b). The histiocytes and lymphoplasmacytic cells infiltrating the myocardium of the left atrium are seen (c). Section from the left atrium also demonstrates fibrosis and large histiocytes in sheets that are accompanied by numerous plasma cells and small mature lymphocytes mass on hematoxylin and eosin-stained section (d).

Mentions: Thoracoscopic-guided biopsy was inconclusive. Imaging done six months later showed no increase in size of mass lesion or mediastinal lymphadenopathy. Decision to surgically excise the mass was done. Left atrial mass demonstrated histiocytes which were immunoreactive to S100. Emperipolesis is engulfment of lymphocytes and erythrocytes by histiocytes which is considered diagnostic of RDD which was noted in the section from left atrial mass (Figure 5). The left atrial mass showed histiocytes and lymphoplasmacytic cells infiltrates with fibrosis and numerous plasma cells. Patient was discharged home and will continue follow-up with annual CMRI.


Extranodal Rosai-Dorfman Disease Involving the Left Atrium: Cardiac MRI, CT, and PET Scan Findings.

Daruwalla VJ, Parekh K, Tahir H, Collins JD, Carr J - Case Rep Radiol (2015)

Immunohistopathology. Section through the left atrial mass shows histiocytes that are immunoreactive to S100 protein immunostaining (a). Emperipolesis is engulfment of lymphocytes and erythrocytes by histiocytes that is considered diagnostic of RDD. Emperipolesis is noted in section from left atrial mass on hematoxylin and eosin-stained sections (b). The histiocytes and lymphoplasmacytic cells infiltrating the myocardium of the left atrium are seen (c). Section from the left atrium also demonstrates fibrosis and large histiocytes in sheets that are accompanied by numerous plasma cells and small mature lymphocytes mass on hematoxylin and eosin-stained section (d).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4477210&req=5

fig5: Immunohistopathology. Section through the left atrial mass shows histiocytes that are immunoreactive to S100 protein immunostaining (a). Emperipolesis is engulfment of lymphocytes and erythrocytes by histiocytes that is considered diagnostic of RDD. Emperipolesis is noted in section from left atrial mass on hematoxylin and eosin-stained sections (b). The histiocytes and lymphoplasmacytic cells infiltrating the myocardium of the left atrium are seen (c). Section from the left atrium also demonstrates fibrosis and large histiocytes in sheets that are accompanied by numerous plasma cells and small mature lymphocytes mass on hematoxylin and eosin-stained section (d).
Mentions: Thoracoscopic-guided biopsy was inconclusive. Imaging done six months later showed no increase in size of mass lesion or mediastinal lymphadenopathy. Decision to surgically excise the mass was done. Left atrial mass demonstrated histiocytes which were immunoreactive to S100. Emperipolesis is engulfment of lymphocytes and erythrocytes by histiocytes which is considered diagnostic of RDD which was noted in the section from left atrial mass (Figure 5). The left atrial mass showed histiocytes and lymphoplasmacytic cells infiltrates with fibrosis and numerous plasma cells. Patient was discharged home and will continue follow-up with annual CMRI.

Bottom Line: Rosai-Dorfman disease (RDD) is a rare entity that usually involves the lymph nodes but extranodal involvements have been seen in numerous cases, although RDD with cardiovascular involvement is extremely rare.We describe a case of a young male who presented with intermittent palpitations and was found to have a left atrium mass.RDD should be considered as one of the differentials even for isolated cardiac lesions.

View Article: PubMed Central - PubMed

Affiliation: Conemaugh Memorial Hospital/Temple University, 1199 Mckinley Avenue, Johnstown, PA 15905, USA.

ABSTRACT
Rosai-Dorfman disease (RDD) is a rare entity that usually involves the lymph nodes but extranodal involvements have been seen in numerous cases, although RDD with cardiovascular involvement is extremely rare. We describe a case of a young male who presented with intermittent palpitations and was found to have a left atrium mass. Our case not only emphasizes the rarity of the above lesion but also highlights the importance of modern-day imaging like computed tomography, Cardiac Magnetic Resonance Imaging (CMRI), and PET scan in characterizing such nonspecific lesions and directing appropriate line of treatment. RDD should be considered as one of the differentials even for isolated cardiac lesions.

No MeSH data available.


Related in: MedlinePlus