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Decreased Resting-State Interhemispheric Functional Connectivity in Parkinson's Disease.

Luo C, Guo X, Song W, Zhao B, Cao B, Yang J, Gong Q, Shang HF - Biomed Res Int (2015)

Bottom Line: Then, we correlated the results from VMHC and clinical features in PD patients.Relative to healthy subject, patients exhibited significantly lower VMHC in putamen and cortical regions associated with sensory processing and motor control (involving sensorimotor and supramarginal cortex), which have been verified to play a critical role in PD.Our results suggest that the functional coordination between homotopic brain regions is impaired in PD patients, extending previous notions about the disconnection of corticostriatal circuit by providing new evidence supporting a disturbance in inter-hemispheric connections in PD.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.

ABSTRACT

Background: Abnormalities in white matter integrity and specific functional network alterations have been increasingly reported in patients with Parkinson's disease (PD). However, little is known about the inter-hemispheric interaction in PD.

Methods: Fifty-one drug naive patients with PD and 51 age- and gender-matched healthy subjects underwent resting-state functional magnetic resonance imaging (rs-fMRI) scans. We compared the inter-hemispheric resting-state functional connectivity between patients with PD and healthy controls, using the voxel-mirrored homotopic connectivity (VMHC) approach. Then, we correlated the results from VMHC and clinical features in PD patients.

Results: Relative to healthy subject, patients exhibited significantly lower VMHC in putamen and cortical regions associated with sensory processing and motor control (involving sensorimotor and supramarginal cortex), which have been verified to play a critical role in PD. In addition, there were inverse relationships between the UPDRS motor scores and VMHC in the sensorimotor, and between the illness duration and VMHC in the supramarginal gyrus in PD patients.

Conclusions: Our results suggest that the functional coordination between homotopic brain regions is impaired in PD patients, extending previous notions about the disconnection of corticostriatal circuit by providing new evidence supporting a disturbance in inter-hemispheric connections in PD.

No MeSH data available.


Related in: MedlinePlus

Correlations between the VMHC values and clinical measures in the patient group. VMHC = voxel-mirrored homotopic connectivity; UPDRS = Unified Parkinson's Disease Rating Scale.
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fig2: Correlations between the VMHC values and clinical measures in the patient group. VMHC = voxel-mirrored homotopic connectivity; UPDRS = Unified Parkinson's Disease Rating Scale.

Mentions: The mean VMHC values were extracted in the three regions with significant group differences. Pearson correlations were performed between VMHC and UPDRS motor scores and duration in the patient group. Significantly negative correlation was observed between VMHC in the primary sensorimotor cortex and the UPDRS motor scores (P < 0.01) (Figure 2). A trend of negative correlation between VMHC in supramarginal cortex and the UPDRS motor scores was also observed (P = 0.06). In addition, VMHC in the supramarginal cortex was also negatively correlated with disease duration (P = 0.02) (Figure 2). No significant correlation was found between VMHC in putamen and clinical variables.


Decreased Resting-State Interhemispheric Functional Connectivity in Parkinson's Disease.

Luo C, Guo X, Song W, Zhao B, Cao B, Yang J, Gong Q, Shang HF - Biomed Res Int (2015)

Correlations between the VMHC values and clinical measures in the patient group. VMHC = voxel-mirrored homotopic connectivity; UPDRS = Unified Parkinson's Disease Rating Scale.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4477209&req=5

fig2: Correlations between the VMHC values and clinical measures in the patient group. VMHC = voxel-mirrored homotopic connectivity; UPDRS = Unified Parkinson's Disease Rating Scale.
Mentions: The mean VMHC values were extracted in the three regions with significant group differences. Pearson correlations were performed between VMHC and UPDRS motor scores and duration in the patient group. Significantly negative correlation was observed between VMHC in the primary sensorimotor cortex and the UPDRS motor scores (P < 0.01) (Figure 2). A trend of negative correlation between VMHC in supramarginal cortex and the UPDRS motor scores was also observed (P = 0.06). In addition, VMHC in the supramarginal cortex was also negatively correlated with disease duration (P = 0.02) (Figure 2). No significant correlation was found between VMHC in putamen and clinical variables.

Bottom Line: Then, we correlated the results from VMHC and clinical features in PD patients.Relative to healthy subject, patients exhibited significantly lower VMHC in putamen and cortical regions associated with sensory processing and motor control (involving sensorimotor and supramarginal cortex), which have been verified to play a critical role in PD.Our results suggest that the functional coordination between homotopic brain regions is impaired in PD patients, extending previous notions about the disconnection of corticostriatal circuit by providing new evidence supporting a disturbance in inter-hemispheric connections in PD.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.

ABSTRACT

Background: Abnormalities in white matter integrity and specific functional network alterations have been increasingly reported in patients with Parkinson's disease (PD). However, little is known about the inter-hemispheric interaction in PD.

Methods: Fifty-one drug naive patients with PD and 51 age- and gender-matched healthy subjects underwent resting-state functional magnetic resonance imaging (rs-fMRI) scans. We compared the inter-hemispheric resting-state functional connectivity between patients with PD and healthy controls, using the voxel-mirrored homotopic connectivity (VMHC) approach. Then, we correlated the results from VMHC and clinical features in PD patients.

Results: Relative to healthy subject, patients exhibited significantly lower VMHC in putamen and cortical regions associated with sensory processing and motor control (involving sensorimotor and supramarginal cortex), which have been verified to play a critical role in PD. In addition, there were inverse relationships between the UPDRS motor scores and VMHC in the sensorimotor, and between the illness duration and VMHC in the supramarginal gyrus in PD patients.

Conclusions: Our results suggest that the functional coordination between homotopic brain regions is impaired in PD patients, extending previous notions about the disconnection of corticostriatal circuit by providing new evidence supporting a disturbance in inter-hemispheric connections in PD.

No MeSH data available.


Related in: MedlinePlus