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Decreased Resting-State Interhemispheric Functional Connectivity in Parkinson's Disease.

Luo C, Guo X, Song W, Zhao B, Cao B, Yang J, Gong Q, Shang HF - Biomed Res Int (2015)

Bottom Line: Then, we correlated the results from VMHC and clinical features in PD patients.Relative to healthy subject, patients exhibited significantly lower VMHC in putamen and cortical regions associated with sensory processing and motor control (involving sensorimotor and supramarginal cortex), which have been verified to play a critical role in PD.Our results suggest that the functional coordination between homotopic brain regions is impaired in PD patients, extending previous notions about the disconnection of corticostriatal circuit by providing new evidence supporting a disturbance in inter-hemispheric connections in PD.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.

ABSTRACT

Background: Abnormalities in white matter integrity and specific functional network alterations have been increasingly reported in patients with Parkinson's disease (PD). However, little is known about the inter-hemispheric interaction in PD.

Methods: Fifty-one drug naive patients with PD and 51 age- and gender-matched healthy subjects underwent resting-state functional magnetic resonance imaging (rs-fMRI) scans. We compared the inter-hemispheric resting-state functional connectivity between patients with PD and healthy controls, using the voxel-mirrored homotopic connectivity (VMHC) approach. Then, we correlated the results from VMHC and clinical features in PD patients.

Results: Relative to healthy subject, patients exhibited significantly lower VMHC in putamen and cortical regions associated with sensory processing and motor control (involving sensorimotor and supramarginal cortex), which have been verified to play a critical role in PD. In addition, there were inverse relationships between the UPDRS motor scores and VMHC in the sensorimotor, and between the illness duration and VMHC in the supramarginal gyrus in PD patients.

Conclusions: Our results suggest that the functional coordination between homotopic brain regions is impaired in PD patients, extending previous notions about the disconnection of corticostriatal circuit by providing new evidence supporting a disturbance in inter-hemispheric connections in PD.

No MeSH data available.


Related in: MedlinePlus

Regions showing significant differences in VMHC between PD patients and healthy controls. Blue colors indicate reduced VMHC in patients compared to the controls. The threshold was set at a corrected P < 0.001. The color bar indicates the T value from t-test between groups. VMHC = voxel-mirrored homotopic connectivity.
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fig1: Regions showing significant differences in VMHC between PD patients and healthy controls. Blue colors indicate reduced VMHC in patients compared to the controls. The threshold was set at a corrected P < 0.001. The color bar indicates the T value from t-test between groups. VMHC = voxel-mirrored homotopic connectivity.

Mentions: Homotopic RSFC was a robust global brain phenomenon, with regional differences in strength (Figure S1 in the Supplementary Material available online at http://dx.doi.org/10.1155/2015/692684), which is consistent with previous work [17]. Group comparisons revealed that patients exhibited lower VMHC than healthy subjects in putamen, sensorimotor cortex (involving precentral, postcentral gyrus and paracentral lobe), and the supramarginal cortex. No region showed greater VMHC in the patient group than in the control group. Figure 1 and Table 2 showed the group comparisons of VMHC values between patients and healthy subjects.


Decreased Resting-State Interhemispheric Functional Connectivity in Parkinson's Disease.

Luo C, Guo X, Song W, Zhao B, Cao B, Yang J, Gong Q, Shang HF - Biomed Res Int (2015)

Regions showing significant differences in VMHC between PD patients and healthy controls. Blue colors indicate reduced VMHC in patients compared to the controls. The threshold was set at a corrected P < 0.001. The color bar indicates the T value from t-test between groups. VMHC = voxel-mirrored homotopic connectivity.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4477209&req=5

fig1: Regions showing significant differences in VMHC between PD patients and healthy controls. Blue colors indicate reduced VMHC in patients compared to the controls. The threshold was set at a corrected P < 0.001. The color bar indicates the T value from t-test between groups. VMHC = voxel-mirrored homotopic connectivity.
Mentions: Homotopic RSFC was a robust global brain phenomenon, with regional differences in strength (Figure S1 in the Supplementary Material available online at http://dx.doi.org/10.1155/2015/692684), which is consistent with previous work [17]. Group comparisons revealed that patients exhibited lower VMHC than healthy subjects in putamen, sensorimotor cortex (involving precentral, postcentral gyrus and paracentral lobe), and the supramarginal cortex. No region showed greater VMHC in the patient group than in the control group. Figure 1 and Table 2 showed the group comparisons of VMHC values between patients and healthy subjects.

Bottom Line: Then, we correlated the results from VMHC and clinical features in PD patients.Relative to healthy subject, patients exhibited significantly lower VMHC in putamen and cortical regions associated with sensory processing and motor control (involving sensorimotor and supramarginal cortex), which have been verified to play a critical role in PD.Our results suggest that the functional coordination between homotopic brain regions is impaired in PD patients, extending previous notions about the disconnection of corticostriatal circuit by providing new evidence supporting a disturbance in inter-hemispheric connections in PD.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.

ABSTRACT

Background: Abnormalities in white matter integrity and specific functional network alterations have been increasingly reported in patients with Parkinson's disease (PD). However, little is known about the inter-hemispheric interaction in PD.

Methods: Fifty-one drug naive patients with PD and 51 age- and gender-matched healthy subjects underwent resting-state functional magnetic resonance imaging (rs-fMRI) scans. We compared the inter-hemispheric resting-state functional connectivity between patients with PD and healthy controls, using the voxel-mirrored homotopic connectivity (VMHC) approach. Then, we correlated the results from VMHC and clinical features in PD patients.

Results: Relative to healthy subject, patients exhibited significantly lower VMHC in putamen and cortical regions associated with sensory processing and motor control (involving sensorimotor and supramarginal cortex), which have been verified to play a critical role in PD. In addition, there were inverse relationships between the UPDRS motor scores and VMHC in the sensorimotor, and between the illness duration and VMHC in the supramarginal gyrus in PD patients.

Conclusions: Our results suggest that the functional coordination between homotopic brain regions is impaired in PD patients, extending previous notions about the disconnection of corticostriatal circuit by providing new evidence supporting a disturbance in inter-hemispheric connections in PD.

No MeSH data available.


Related in: MedlinePlus