Limits...
Inter-individual stereotypy of the Platynereis larval visual connectome.

Randel N, Shahidi R, Verasztó C, Bezares-Calderón LA, Schmidt S, Jékely G - Elife (2015)

Bottom Line: It is less well understood, however, to what extent entire neural circuits of different individuals are similar.Previously, we reported the neuronal connectome of the visual eye circuit from the head of a Platynereis dumerilii larva (Randel et al., 2014).Our work shows the extent to which the eye circuitry in Platynereis larvae is hard-wired.

View Article: PubMed Central - PubMed

Affiliation: Max Planck Institute for Developmental Biology, Tübingen, Germany.

ABSTRACT
Developmental programs have the fidelity to form neural circuits with the same structure and function among individuals of the same species. It is less well understood, however, to what extent entire neural circuits of different individuals are similar. Previously, we reported the neuronal connectome of the visual eye circuit from the head of a Platynereis dumerilii larva (Randel et al., 2014). We now report a full-body serial section transmission electron microscopy (ssTEM) dataset of another larva of the same age, for which we describe the connectome of the visual eyes and the larval eyespots. Anatomical comparisons and quantitative analyses of the two circuits reveal a high inter-individual stereotypy of the cell complement, neuronal projections, and synaptic connectivity, including the left-right asymmetry in the connectivity of some neurons. Our work shows the extent to which the eye circuitry in Platynereis larvae is hard-wired.

No MeSH data available.


Related in: MedlinePlus

Reciprocal connection strength between all neuron pairs in the complete visual circuit (HT9-4).Strength is defined as the geometric mean of the number of synapses of a given neuron ‘A’ on another neuron ‘B’ and the number of synapses of neuron ‘B’ on neuron ‘A’. Single neuron identifiers are not shown for simplicity.DOI:http://dx.doi.org/10.7554/eLife.08069.009
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4477197&req=5

fig2s2: Reciprocal connection strength between all neuron pairs in the complete visual circuit (HT9-4).Strength is defined as the geometric mean of the number of synapses of a given neuron ‘A’ on another neuron ‘B’ and the number of synapses of neuron ‘B’ on neuron ‘A’. Single neuron identifiers are not shown for simplicity.DOI:http://dx.doi.org/10.7554/eLife.08069.009

Mentions: We also identified all reciprocal connections for HT9-4 and found the same strong reciprocal IN1 motif as that of HT9-3 (Figure 2—figure supplement 2, Figure 2—source data 1). Additionally, we scored the correlation of the synaptic maturation of the HT9-4 photoreceptor cells (PRCs) with photoreceptor-cell rhabdom volume and axon length and found similar relationships as in HT9-3 (Figure 3—figure supplement 1, Figure 3—figure supplement 1—source data 1). All these measures indicate that the Platynereis eye circuit is strongly stereotypical at the global level of its synaptic connectivity.


Inter-individual stereotypy of the Platynereis larval visual connectome.

Randel N, Shahidi R, Verasztó C, Bezares-Calderón LA, Schmidt S, Jékely G - Elife (2015)

Reciprocal connection strength between all neuron pairs in the complete visual circuit (HT9-4).Strength is defined as the geometric mean of the number of synapses of a given neuron ‘A’ on another neuron ‘B’ and the number of synapses of neuron ‘B’ on neuron ‘A’. Single neuron identifiers are not shown for simplicity.DOI:http://dx.doi.org/10.7554/eLife.08069.009
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4477197&req=5

fig2s2: Reciprocal connection strength between all neuron pairs in the complete visual circuit (HT9-4).Strength is defined as the geometric mean of the number of synapses of a given neuron ‘A’ on another neuron ‘B’ and the number of synapses of neuron ‘B’ on neuron ‘A’. Single neuron identifiers are not shown for simplicity.DOI:http://dx.doi.org/10.7554/eLife.08069.009
Mentions: We also identified all reciprocal connections for HT9-4 and found the same strong reciprocal IN1 motif as that of HT9-3 (Figure 2—figure supplement 2, Figure 2—source data 1). Additionally, we scored the correlation of the synaptic maturation of the HT9-4 photoreceptor cells (PRCs) with photoreceptor-cell rhabdom volume and axon length and found similar relationships as in HT9-3 (Figure 3—figure supplement 1, Figure 3—figure supplement 1—source data 1). All these measures indicate that the Platynereis eye circuit is strongly stereotypical at the global level of its synaptic connectivity.

Bottom Line: It is less well understood, however, to what extent entire neural circuits of different individuals are similar.Previously, we reported the neuronal connectome of the visual eye circuit from the head of a Platynereis dumerilii larva (Randel et al., 2014).Our work shows the extent to which the eye circuitry in Platynereis larvae is hard-wired.

View Article: PubMed Central - PubMed

Affiliation: Max Planck Institute for Developmental Biology, Tübingen, Germany.

ABSTRACT
Developmental programs have the fidelity to form neural circuits with the same structure and function among individuals of the same species. It is less well understood, however, to what extent entire neural circuits of different individuals are similar. Previously, we reported the neuronal connectome of the visual eye circuit from the head of a Platynereis dumerilii larva (Randel et al., 2014). We now report a full-body serial section transmission electron microscopy (ssTEM) dataset of another larva of the same age, for which we describe the connectome of the visual eyes and the larval eyespots. Anatomical comparisons and quantitative analyses of the two circuits reveal a high inter-individual stereotypy of the cell complement, neuronal projections, and synaptic connectivity, including the left-right asymmetry in the connectivity of some neurons. Our work shows the extent to which the eye circuitry in Platynereis larvae is hard-wired.

No MeSH data available.


Related in: MedlinePlus